Patents by Inventor Robert E. Schaub

Robert E. Schaub has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel hydroxy substituted prostanoic acids, esters, congeners, intermediates and process
    Patent number: 4439365
    Abstract: This disclosure describes certain 11-hydroxy and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives useful as bronchodilators, anti-ulcer agents, or as intermediates.
    Type: Grant
    Filed: July 18, 1979
    Date of Patent: March 27, 1984
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Martin J. Weiss, John F. Poletto, Robert E. Schaub, Karel F. Bernady
  • Poly-cation salts of bis (or tris) 4-O-polyhexose-thio-arylene sulfate derivatives
    Patent number: 4435387
    Abstract: Poly-cation salts of bis (or tris) 4-O-polyhexose-thio-arylene sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: March 6, 1984
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • Bis(4-O-polyhexaose-thio)-phenyl ureas and method of use
    Patent number: 4431636
    Abstract: Poly-cation salts of bis (4-O-polyhexaose-thio)-phenyl urea sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: May 24, 1982
    Date of Patent: February 14, 1984
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • Poly-cation salts of bis(or tris)[4-0-monohexose-thio]-arylene sulfate derivatives
    Patent number: 4431638
    Abstract: Poly-cation salts of bis(or tris)[4-O-monohexose-thio]-arylene sulfate derivatives useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: February 14, 1984
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • Polycation salts of bis (or tris) [4-O-polyhexose-oxy]-arylene sulfate derivatives
    Patent number: 4431637
    Abstract: Poly-cation salts of bis (or tris) [4-O-polyhexose-oxy]-arylene sulfate derivatives useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: February 14, 1984
    Assignee: American Cyanamid Company
    Inventors: Janis Upeslacis, Robert E. Schaub, Seymour Bernstein
  • Poly cation salts of monohexosethio (or oxy) alkyl diamides
    Patent number: 4404195
    Abstract: N,N'-Bis[4-[(2,3,4,6-tetra-O-sulfo-.alpha.(or .beta.)-D-glucopyranosyl)thio(or oxy)]phenyl]alkyl diamides, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process for the preparation of such intermediates and end products.
    Type: Grant
    Filed: April 16, 1982
    Date of Patent: September 13, 1983
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • N,N'-Bis(glucopyranosyl-D-glucopyranosyloxyphenyl)alkaline and methods of use
    Patent number: 4401661
    Abstract: N,N'-Bis[4-[2,3,6-tri-O-sulfo-4-O-(2,3,4,6-tetra-O-sulfo-.alpha.(and .beta.)-D-glucopyranosyl)-.alpha.(and .beta.)-D-glucopyranosyloxy]phenyl]alkyldiamides and alkyldiamines, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: April 16, 1982
    Date of Patent: August 30, 1983
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • Modulators of the complement system
    Patent number: 4399126
    Abstract: N,N'-Bis[4-[2,3,6,-tri-O-sulfo-4-O-(2,3,4,6-tetra-O-sulfo-.alpha.(and .beta.)-D-glucopyranosyl)-.alpha.(and .beta.)-D-glucopyranosylthio or sulfinyl or sulfonyl]phenyl]alkyldiamides and alkyldiamines, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: April 16, 1982
    Date of Patent: August 16, 1983
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones
    Patent number: 4343949
    Abstract: This disclosure describes 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.
    Type: Grant
    Filed: October 12, 1979
    Date of Patent: August 10, 1982
    Assignee: American Cyanamid Company
    Inventors: Karel F. Bernady, Middleton B. Floyd, Jr., John F. Poletto, Robert E. Schaub, Martin J. Weiss
  • Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones
    Patent number: 4293704
    Abstract: This invention relates to novel 4-oxy-2-substituted-cyclopent-2-en-1-ones of the following general formula: ##STR1## and the optical antipodes, racemic mixtures, and diastereomeric mixtures thereof wherein p is an integer from 2 to 6, inclusive, and J is hydrogen or an appropriate and compatible blocking group such as tetrahydropyranyl or tri(lower alkyl)silyl. Suitable lower alkyl groups contemplated by the present invention are those having up to four carbon atoms such as methyl, ethyl, isopropyl, tert-butyl, etc.
    Type: Grant
    Filed: January 28, 1980
    Date of Patent: October 6, 1981
    Assignee: American Cyanamid Company
    Inventors: Karel F. Bernady, Middleton B. Floyd, Jr., John F. Poletto, Robert E. Schaub, Martin J. Weiss
  • Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones
    Patent number: 4237316
    Abstract: This disclosure describes novel 4-oxy-2-substituted-cyclopent-2-en-1-ones useful as intermediates for the preparation of homo and nor prostaglandins of the E.sub.2, E.sub.3 and F series.
    Type: Grant
    Filed: September 25, 1975
    Date of Patent: December 2, 1980
    Assignee: American Cyanamid Company
    Inventors: Karel F. Bernady, Middleton B. Floyd, Jr., John F. Poletto, Robert E. Schaub, Martin J. Weiss
  • Novel prostaglandins
    Patent number: 4180677
    Abstract: This disclosure describes novel 15-hydroxy prostanoic acid derivatives having anti-ulcer, bronchodilator, and hypotensive activity.
    Type: Grant
    Filed: October 28, 1977
    Date of Patent: December 25, 1979
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Martin J. Weiss
  • Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclo-pentenones
    Patent number: 4179574
    Abstract: This disclosure describes 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostenoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.
    Type: Grant
    Filed: September 22, 1977
    Date of Patent: December 18, 1979
    Assignee: American Cyanamid Company
    Inventors: Karel F. Bernady, Middleton B. Floyd, Jr., John F. Poletto, Robert E. Schaub, Martin J. Weiss
  • Novel hydroxy substituted 15-deoxy-5-cis-prostenoic acids and esters
    Patent number: 4179451
    Abstract: This disclosure describes certain hydroxy substituted 15-deoxy-5-cis-prostenoic acids and esters useful as hypotensive agents, anti-ulcer agents, bronchodilators, anti-microbial agents, anticonvulsants, or as intermediates.
    Type: Grant
    Filed: June 12, 1978
    Date of Patent: December 18, 1979
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Martin J. Weiss, William J. McGahren, Robert E. Schaub
  • 16,16-Spirocycloalkyl prostaglandin derivatives
    Patent number: 4178461
    Abstract: This disclosure describes novel 15-hydroxy-16,16-spirocycloalkyl prostanoic acids and derivatives and congeners thereof which are useful as bronchodilators and gastric acid secretion inhibitors.
    Type: Grant
    Filed: March 16, 1977
    Date of Patent: December 11, 1979
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Martin J. Weiss
  • Cycloalkyl and cycloalkenyl prostaglandin congeners
    Patent number: 4152524
    Abstract: This disclosure describes novel 15-hydroxy prostanoic acids and derivatives thereof useful as bronchodilators and hypotensive agents.
    Type: Grant
    Filed: January 6, 1977
    Date of Patent: May 1, 1979
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Martin J. Weiss
  • Novel 11-hydroxy-9-keto-5,6-cis-13,14-cis-prostadienoic acid derivatives
    Patent number: 4123456
    Abstract: This disclosure describes certain 11-hydroxy and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents, or as intermediates.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: October 31, 1978
    Assignee: American Cyanamid Company
    Inventors: Karel F. Bernady, Middleton B. Floyd, Jr., John F. Poletto, Robert E. Schaub, Martin J. Weiss
  • 3-Alkyl-2-(6-carboxyhexyl) cyclopentanones and esters and salts thereof
    Patent number: 4074056
    Abstract: This disclosure describes compounds of the class of substituted 9-oxoprostanoic acids and the esters and cationic salts thereof, useful as antimicrobial agents, hypotensive agents, anti-ulcer agents, or as intermediates, and novel processes for preparing the same.
    Type: Grant
    Filed: January 4, 1977
    Date of Patent: February 14, 1978
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Karel F. Bernady, Martin J. Weiss