Patents by Inventor Robert E. Schwartz
Robert E. Schwartz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5386009Abstract: The present invention is directed to water-soluble derivatives of antibiotic lipopeptides. The derivatives have good solubility properties in aqueous medium, rendering them more useful as therapeutic agents.Type: GrantFiled: March 19, 1990Date of Patent: January 31, 1995Assignee: Merck & Co. Inc.Inventors: Milton L. Hammond, Robert E. Schwartz, James M. Balkovec
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Patent number: 5385884Abstract: There are disclosed lipopeptide derviatives of the general formula: ##STR1## where the substituents are defined herein which have antifungal and antiprotozoal activity. There are also disclosed pharmaceutical compositions containing these compounds.Type: GrantFiled: August 27, 1991Date of Patent: January 31, 1995Assignee: Merck & Co. Inc.Inventors: Milton L. Hammond, Robert E. Schwartz, James M. Balkovec
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Patent number: 5366880Abstract: A new antibiotic cyclic lipopeptide having the formula ##STR1## wherein R is H or OH and a method of producing is described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.Type: GrantFiled: May 21, 1993Date of Patent: November 22, 1994Assignee: Merck & Co., Inc.Inventors: Robert E. Schwartz, Prakash S. Masurekar, David F. Sesin, Jerrold M. Liesch, Thomas C. Hallada, Otto D. Hensens
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Patent number: 5348970Abstract: A compound of the formula 1: ##STR1## is produced via fermentation of a fungal isolate ATCC no. 74235. The organism is included herein, as well as a process for production of the compound, a pharmaceutical composition and a method of treatment.Type: GrantFiled: September 22, 1993Date of Patent: September 20, 1994Assignee: Merck & Co., Inc.Inventors: Robert E. Schwartz, Janet C. Onishi, Gerald F. Bills, Robert A. Giacobbe, Fernando Pelaez, Maria T. Diez, Francisca Vicente, Julian Gorrochategui, Gregory L. Helms, Barnali Pramanik
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Patent number: 5344307Abstract: Improved methods and burner apparatus are provided for discharging mixtures of fuel and air into furnace spaces wherein said mixtures are burned and flue gases having low NO.sub.x content are formed therefrom. The methods basically comprise discharging a first fuel mixture containing a portion of the fuel and flue gases from the furnace space into the furnace space whereby the mixture is burned in a primary reaction zone therein and flue gases having low NO.sub.x content are formed therefrom, and then discharging the remaining portion of the fuel into a secondary reaction zone wherein the remaining portion of fuel mixes with air and flue gases to form a second fuel mixture which is burned in the secondary reaction zone and additional flue gases having low NO.sub.x content are formed therefrom.Type: GrantFiled: August 25, 1993Date of Patent: September 6, 1994Assignee: Koch Engineering Company, Inc.Inventors: Robert E. Schwartz, Richard T. Waibel, Paul M. Rodden, Samuel O. Napier
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Patent number: 5336756Abstract: A process for obtaining a compound of the formula ##STR1## in crystalline form by solubilizing the compound in warm aqueous n-propanol and then allowing the solution to stand at ambient temperature until crystal formation is substantially complete is described. The crystalline compound obtained thereby is also described.Type: GrantFiled: August 27, 1991Date of Patent: August 9, 1994Assignee: Merck & Co., Inc.Inventors: Robert E. Schwartz, August J. Kempf, David J. Mathre
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Patent number: 5330973Abstract: The present invention is directed to water-soluble derivatives of antibiotic lipopeptides. The derivatives have good solubility properties in aqueous medium, rendering them more useful as therapeutic agents.Type: GrantFiled: March 19, 1990Date of Patent: July 19, 1994Assignee: Merck & Co., Inc.Inventors: Milton L. Hammond, Robert E. Schwartz, James M. Balkovec
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Patent number: 5310873Abstract: A cyclohexapeptide base which is the nucleus of closely related antibiotics obtained by culturing Zalerion arboricola and its salts are described. They are useful intermediates for the preparation of new semisynthetic compounds having antimicrobial activity.Type: GrantFiled: March 12, 1990Date of Patent: May 10, 1994Assignee: Merck & Co., Inc.Inventors: Dennis M. Schmatz, Jan S. Tkacz, Robert E. Schwartz, Mervyn Turner
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Patent number: 5306708Abstract: A new antibiotic cyclic lipopeptide having the formula ##STR1## wherein R is H SEQ ID NO:1 or OH SEQ ID NO:2 and a method of producing is described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.Type: GrantFiled: December 19, 1990Date of Patent: April 26, 1994Assignee: Merck & Co., Inc.Inventors: Robert E. Schwartz, David F. Sesin, Prakash S. Masurekar, Jerrold M. Liesch, Thomas C. Hallada, Otto D. Hensens
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Patent number: 5275552Abstract: Improved gas burner apparatus and methods of burning fuel gas-air mixtures are provided whereby flue gases having low NO.sub.x contents are formed. The burner apparatus includes a refractory burner tile having an air discharge opening therein and a wall surrounding the opening which extends into the furnace space and provides a mixing zone therein. At least one passage is formed in the burner tile which opens into the mixing zone and fuel gas is jetted through the passage whereby flue gases are drawn therethrough and a fuel gas-flue gases mixture is discharged into the mixing zone. The fuel gas-flue gases mixture is swirled in the mixing zone and mixes with air therein, and the resulting mixture is discharged and burned in a primary reaction zone in the furnace space.Type: GrantFiled: June 17, 1993Date of Patent: January 4, 1994Assignee: John Zink Company, A Division of Koch Engineering Co. Inc.Inventors: Robert E. Schwartz, Samuel O. Napier, Andrew P. Jones
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Patent number: 5269678Abstract: Improved methods and burner apparatus are provided for discharging mixtures of fuel and air into furnace spaces wherein said mixtures are burned and flue gases having low NO.sub.x content are formed therefrom. The methods basically comprise discharging a first fuel mixture containing a portion of the fuel and flue gases from the furnace space into the furnace space whereby the mixture is burned in a primary reaction zone therein and flue gases having low NO.sub.x content are formed therefrom, and then discharging the remaining portion of the fuel into a secondary reaction zone wherein the remaining portion of fuel mixes with air and flue gases to form a second fuel mixture which is burned in the secondary reaction zone and additional flue gases having low NO.sub.x content are formed therefrom.Type: GrantFiled: July 29, 1992Date of Patent: December 14, 1993Assignee: Koch Engineering Company, Inc.Inventors: Robert E. Schwartz, Richard T. Waibel, Paul M. Rodden, Samuel O. Napier
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Patent number: 5238395Abstract: Improved gas burner apparatus and methods of burning fuel gas-air mixtures are provided whereby flue gases having low NO.sub.x contents are formed. The burner apparatus includes a refractory burner tile having an air discharge opening therein and a wall surrounding the opening which extends into the furnace space and provides a mixing zone therein. At least one passage is formed in the burner tile which opens into the mixing zone and fuel gas is jetted through the passage whereby flue gases are drawn therethrough and a fuel gas-flue gases mixture is discharged into the mixing zone. The fuel gas-flue gases mixture is swirled in the mixing zone and mixes with air therein, and the resulting mixture is discharged and burned in a primary reaction zone in the furnace space.Type: GrantFiled: March 27, 1992Date of Patent: August 24, 1993Assignee: John Zink CompanyInventors: Robert E. Schwartz, Samuel O. Napier, Andrew P. Jones
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Patent number: 5202309Abstract: An antibiotic agent produced by the cultivation of Zalerion arboricola which is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity is described. Its production and isolation are also described.Type: GrantFiled: August 19, 1991Date of Patent: April 13, 1993Assignee: Merck & Co., Inc.Inventors: Robert E. Schwartz, Jerrold M. Liesch, Raymond F. White, Otto D. Hensens, Henry Joshua, Dennis M. Schmatz
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Patent number: 5200079Abstract: A circular clarifier includes a skimmer assembly mounted on a rotatable arm of the clarifier. The skimmer assembly includes a parallelogram linkage having a pair of end links pivotably connected between upper and lower intermediate links. The skimmer blade is mounted to one of the end links to skim the liquid containing volume of the clarifier. The parallelogram linkage is mounted to the rotating arm by a support assembly at upper and lower pivot connections. These pivot connections are positioned at central portions of the respective intermediate links such that both of the intermediate links extend outwardly on both sides of the respective pivot connection. Either a counterweight or a floatation element is mounted to the parallelogram linkage to bias the linkage for rotation about the pivot connections to position the skimmer blade in an upper position.Type: GrantFiled: June 20, 1990Date of Patent: April 6, 1993Assignee: McNish CorporationInventors: Robert E. Schwartz, Donald C. Vock
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Patent number: 5195884Abstract: Improved low NO.sub.x formation gas burner apparatus and methods of burning uel are provided. The burner apparatus includes a refractory burner tile having a base portion and a wall portion, the wall portion extending into the furnace, surrounding a central area of the base portion and having exterior sides which are slanted. Means are attached to the burner tile for mixing a portion of the fuel gas with the air and discharging the resulting mixture into a primary burning zone in the furnace from within the space defined by the wall portion of the burner tile. At least one secondary fuel gas nozzle means positioned for discharging the remaining portion of the fuel gas adjacent to an external slanted side of the wall portion whereby the fuel gas mixes with flue gases and air in the furnace and burns in a secondary burning zone therein.Type: GrantFiled: March 27, 1992Date of Patent: March 23, 1993Assignee: John Zink Company, A Division of Koch Engineering Company, Inc.Inventors: Robert E. Schwartz, Samuel O. Napier, Andrew P. Jones, Roger K. Noble
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Patent number: 5194377Abstract: An antibiotic agent produced by the cultivation of Zalerion arboricola which is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity is described. Its production and isolation are also described.Type: GrantFiled: August 9, 1991Date of Patent: March 16, 1993Assignee: Merck & Co., Inc.Inventors: Robert E. Schwartz, Raymond F. White
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Patent number: 5194155Abstract: A clarifier having a flocculating well is provided with two concentric drive cages: an outer drive cage that drives flocculation blades in rotation, and an inner drive cage that drives sludge collection arms across the base of the clarifier. Each drive cage is connected to a respective annular output gear, and each output gear is driven by a respective drive gear. The output gears are stacked one above the other, and each of the drive gears is connected to a respective speed reduction unit situated above the upper of the two output gears. The drive gear for the lower output gear is connected to the respective speed reduction unit by a drive shaft which passes through the upper output gear. Each of the speed reduction units is driven by a respective motor.Type: GrantFiled: June 20, 1990Date of Patent: March 16, 1993Assignee: McNish CorporationInventor: Robert E. Schwartz
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Patent number: 5180302Abstract: An improved radiant gas burner which includes a refractory burner tile hag an elongated passageway extending therethrough and a fuel-air mixture burner tube disposed within the passageway. The burner tube is of a one-piece elongated construction, includes a nozzle portion at the interior end of the passageway and is connected to means for introducing fuel gas and air therein by a threaded connection positioned adjacent the exterior end of the passageway. Secondary fuel is discharged from the passageway at a location adjacent the nozzle portion of the burner tube. An improved method of burning fuel gas and air using a radiant gas burner is also provided.Type: GrantFiled: February 28, 1992Date of Patent: January 19, 1993Assignee: John Zink Company, a Division of Koch Engineering Company, Inc.Inventors: Robert E. Schwartz, Robert R. Trimble
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Patent number: 5154596Abstract: Improved methods and burner apparatus are provided for discharging mixtures f fuel and air into furnace spaces wherein said mixtures are burned and flue gases having low NO.sub.x content are formed therefrom. The methods basically comprise discharging a first fuel mixture containing a portion of the fuel and flue gases from the furnace space into the furnace space whereby the mixture is burned in a primary reaction zone therein and flue gases having low NO.sub.x content are formed therefrom, and then discharging the remaining portion of the fuel into a secondary reaction zone wherein the remaining portion of fuel mixes with air and flue gases to form a second fuel mixture which is burned in the secondary reaction zone and additional flue gases having low NO.sub.x contents are formed therefrom.Type: GrantFiled: February 13, 1992Date of Patent: October 13, 1992Assignee: John Zink Company, a Division of Koch Engineering Company, Inc.Inventors: Robert E. Schwartz, Richard T. Waibel, Paul M. Rodden, Samuel O. Napier
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Patent number: 5098282Abstract: Improved methods and burner apparatus are provided for discharging mixtures of fuel and air into furnace spaces wherein said mixtures are burned and flue gases having low NO.sub.x content are formed therefrom. The methods basically comprise discharging a first fuel mixture containing a portion of the fuel and flue gases from the furnace space into the furnace space whereby the mixture is burned in a primary reaction zone therein and flue gases having low NO.sub.x content are formed therefrom, and then discharging the remaining portion of the fuel into a secondary reaction zone wherein the remaining portion of fuel mixes with air and flue gases to form a second fuel mixture which is burned in the secondary reaction zone and additional flue gases having low NO.sub.x content are formed therefrom.Type: GrantFiled: September 7, 1990Date of Patent: March 24, 1992Assignee: John Zink CompanyInventors: Robert E. Schwartz, Richard T. Waibel, Paul M. Rodden, Samuel O. Napier