Patents by Inventor Robert E. Settlage

Robert E. Settlage has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for structural characterization of biological moieties through HPLC separation
    Patent number: 6315905
    Abstract: A system allows routine coupling of HPLC separations to sheathless &mgr;-ESI sources for MS analysis. Characteristics of this system include stable electrospray throughout the HPLC gradient at low and high flow rates, lower background than conventional sources, and control over the width of eluting HPLC peaks without degradation of HPLC performance. This system includes a pre-column solvent flow splitter, a metal union in the split waste line for application of &mgr;-ESI voltage, a divert valve containing two different size restrictors for control of flow, and pulled fused silica capillaries as &mgr;-ESI emitters. The pulled tips allowed stable operation of the system with column flow rates ranging from ca. 5→250 nL/min.
    Type: Grant
    Filed: January 24, 2000
    Date of Patent: November 13, 2001
    Assignee: University of Virginia Patent Foundation
    Inventors: Robert E. Settlage, Donald F. Hunt, Robert E. Christian
  • Apparatus for structural characterization of biological moieties through HPLC separation
    Patent number: 6139734
    Abstract: A system allows routine coupling of HPLC separations to sheathless .mu.-ESI sources for MS analysis. Characteristics of this system include stable electrospray throughout the HPLC gradient at low and high flow rates, lower background than conventional sources, and control over the width of eluting HPLC peaks without degradation of HPLC performance. This system includes a pre-column solvent flow splitter, a metal union in the split waste line for application of .mu.-ESI voltage, a divert valve containing two different size restrictors for control of flow, and pulled fused silica capillaries as .mu.-ESI emitters. The pulled tips allowed stable operation of the system with column flow rates ranging from ca. 5->250 nL/min.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: October 31, 2000
    Assignee: University of Virginia Patent Foundation
    Inventors: Robert E. Settlage, Donald F. Hunt, Robert E. Christian