Patents by Inventor Robert E. Short

Robert E. Short has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reconstitutable Microsphere Compositions Useful As Ultrasonic Contrast Agents
    Publication number: 20160206761
    Abstract: Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugar) in specified amounts that reduce aggregation of the particles comprising the suspension.
    Type: Application
    Filed: December 12, 2012
    Publication date: July 21, 2016
    Inventors: Thomas B. Ottoboni, Robert E. Short
  • Reconstitutable Microsphere Compositions Useful As Ultrasonic Contrast Agents
    Publication number: 20140161726
    Abstract: Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugar) in specified amounts that reduce aggregation of the particles comprising the suspension.
    Type: Application
    Filed: December 12, 2012
    Publication date: June 12, 2014
    Inventors: Thomas B. Ottoboni, Robert E. Short
  • Nanobubbles useful as an ultrasonic contrast agent for the lymphatic system
    Patent number: 8486444
    Abstract: A composition is provided accompanying nanoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they rupture on exposure to predetermined ultrasound energy. The composition is useful for identifying sentinel lymph nodes.
    Type: Grant
    Filed: August 15, 2011
    Date of Patent: July 16, 2013
    Assignee: University of Pittsburgh-of the Commonwealth System of Higher Education
    Inventors: Thomas B. Ottoboni, Robert E. Short, Jeffrey D. Gabe
  • Reconstitutable microsphere compositions useful as ultrasonic contrast agents
    Patent number: 8460637
    Abstract: Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugar) in specified amounts that reduce aggregation of the particles comprising the suspension.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: June 11, 2013
    Assignee: University of Pittsburgh-Of the Commonwealth System of Higher Education
    Inventors: Thomas B. Ottoboni, Robert E. Short
  • Reconstitutable Microsphere Compositions Useful As Ultrasonic Contrast Agents
    Publication number: 20120052016
    Abstract: Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugar) in specified amounts that reduce aggregation of the particles comprising the suspension.
    Type: Application
    Filed: October 4, 2011
    Publication date: March 1, 2012
    Inventors: Thomas B. Ottoboni, Robert E. Short
  • Nanobubbles Useful As An Ultrasonic Contrast Agent For The Lymphatic System
    Publication number: 20120034170
    Abstract: A composition is provided accompanying nanoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they rupture on exposure to predetermined ultrasound energy. The composition is useful for identifying sentinel lymph nodes.
    Type: Application
    Filed: August 15, 2011
    Publication date: February 9, 2012
    Inventors: Thomas B. Ottoboni, Robert E. Short, Jeffrey D. Gabe
  • NANOBUBBLES USEFUL AS AN ULTRASONIC CONTRAST AGENT FOR LYMPHATIC SYSTEM
    Publication number: 20110165088
    Abstract: A composition is provided accompanying nonoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they rupture on exposure to predetermined ultrasound energy. The composition is useful for identifying sentinel lymph nodes.
    Type: Application
    Filed: August 19, 2008
    Publication date: July 7, 2011
    Applicant: Point Biomedical Corporation
    Inventors: Thomas B. Ottoboni, Robert E. Short, Jeffrey D. Gabe
  • RECONSTITUTABLE MICROSPHERE COMPOSITIONS USEFUL AS ULTRASONIC CONTRAST AGENTS
    Publication number: 20090274628
    Abstract: Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugars) in specified amounts that reduce aggregation of the particles comprising the suspension.
    Type: Application
    Filed: December 5, 2008
    Publication date: November 5, 2009
    Applicant: Point Biomedical Corporation
    Inventors: Thomas B. Ottoboni, Robert E. Short
  • MICROPARTICLES USEFUL AS ULTRASONIC CONTRAST AGENTS AND FOR DELIVERY OF DRUGS INTO THE BLOODSTREAM
    Publication number: 20090081130
    Abstract: Microparticles are provided comprising a shell of an outer layer of a biologically compatible material and an inner layer of biodegradable polymer. The core of the microparticles contain a gas, liquid or solid for use in drug delivery or as a contrast agent for ultrasonic contrast imaging. The microparticles are capable of passing through the capillary systems of a subject.
    Type: Application
    Filed: December 5, 2008
    Publication date: March 26, 2009
    Applicant: Point Biomedical Corporation
    Inventors: Thomas B. Ottoboni, Robert E. Short, Ronald K. Yamamoto
  • METHOD OF IMAGING LYMPHATIC SYSTEM USING NANOCAPSULE COMPOSITIONS
    Publication number: 20080319320
    Abstract: A composition is provided accompanying nanoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they rupture on exposure to predetermined ultrasound energy. The composition is useful for identifying sentinel lymph nodes.
    Type: Application
    Filed: August 20, 2008
    Publication date: December 25, 2008
    Applicant: Point Biomedical Corporation
    Inventors: Thomas B. Ottoboni, Robert E. Short, Jeffrey D. Gabe
  • NANOBUBBLES USEFUL AS AN ULTRASONIC CONTRAST AGENT FOR THE LYMPHATIC SYSTEM
    Publication number: 20080181853
    Abstract: A composition is provided accompanying nanoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they rupture on exposure to predetermined ultrasound energy. The composition is useful for identifying sentinel lymph nodes.
    Type: Application
    Filed: July 20, 2007
    Publication date: July 31, 2008
    Applicant: POINT BIOMEDICAL CORPORATION
    Inventors: Thomas B. Ottoboni, Robert E. Short, Jeffrey D. Gabe
  • Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
    Patent number: 6919068
    Abstract: A method is provided to prepare gas-filled, porous microparticles having a polymer matrix interior which are useful as ultrasound echogenic contrast agents. An oil-in-water suspension is formed, both phases are frozen, then the aqueous and nonaqueous frozen phases are removed by sublimation. The resulting porous microparticles can receive a gas and be used as an ultrasound contrast agent.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: July 19, 2005
    Assignee: Point Biomedical Corporation
    Inventor: Robert E. Short
  • Method of preparing gas-filled polymer matrix microparticles useful for delivering drug
    Publication number: 20040185108
    Abstract: A method is provided to prepare drug containing gas-filled porous microparticles having a polymer matrix interior which are useful for ultrasound mediated targeted delivery of a drug. An oil-in-water suspension is formed, both phases are frozen, then the aqueous and nonaqueous frozen phases are removed by sublimation.
    Type: Application
    Filed: March 18, 2003
    Publication date: September 23, 2004
    Inventors: Robert E. Short, Thomas B. Ottoboni
  • Hollow microspheres with controlled fragility for medical use
    Patent number: 6776761
    Abstract: A composition for ultrasonic imaging is described having a microbubble population of controlled fragility. The microbubbles comprise an outer shell and a hollow core. The ratio of shell thickness to microbubble diameter is substantially similar across the population of microbubbles. A method of using such composition for imaging a fluid filled cavity, vessel or tissue is described.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: August 17, 2004
    Assignee: Point Biomedical Corporation
    Inventors: Thomas B. Ottoboni, E. Glenn Tickner, Robert E. Short, Ronald K. Yamamoto
  • Microparticles useful as ultrasonic contrast agents
    Publication number: 20040086459
    Abstract: Microparticles are provided comprising a shell of an outer layer of a biologically compatible material and an inner layer of biodegradable polymer. The core of the microparticles contain a gas, liquid or solid for use in drug delivery or as a contrast agent for ultrasonic contrast imaging. The microparticles are capable of passing through the capillary systems of a subject.
    Type: Application
    Filed: October 20, 2003
    Publication date: May 6, 2004
    Inventors: Thomas B. Ottoboni, Robert E. Short, Ronald K. Yamamoto
  • Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream
    Publication number: 20030215394
    Abstract: A microparticle composition is provided for delivery of a pharmaceutical agent by ultrasound triggering. The microparticles have a porous, gas-containing interior polymer matrix and a plurality of cavities in the matrix which contain a gas and the agent. Methods for forming the microparticles and their use in ultrasonic diagnostic imaging and drug delivery are also provided.
    Type: Application
    Filed: May 17, 2002
    Publication date: November 20, 2003
    Inventors: Robert E. Short, Thomas B. Ottoboni, Matthew B. Kerby
  • Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
    Publication number: 20030215393
    Abstract: A method is provided to prepare gas-filled, porous microparticles having a polymer matrix interior which are useful as ultrasound echogenic contrast agents. An oil-in-water suspension is formed, both phases are frozen, then the aqueous and nonaqueous frozen phases are removed by sublimation. The resulting porous microparticles can receive a gas and be used as an ultrasound contrast agent.
    Type: Application
    Filed: May 17, 2002
    Publication date: November 20, 2003
    Inventor: Robert E. Short
  • Hollow microspheres with controlled fragility for medical use
    Publication number: 20030036697
    Abstract: A composition for ultrasonic imaging is described having a microparticle population of controlled fragility. A method of using such composition for imaging a fluid filled cavity, vessel or tissue is described.
    Type: Application
    Filed: August 20, 2002
    Publication date: February 20, 2003
    Inventors: Thomas B. Ottoboni, E. Glenn Tickner, Robert E. Short, Ronald K. Yamamoto
  • Excipient for the lyophilization of aqueous suspensions of microparticles
    Patent number: 6482518
    Abstract: An excipient for lyophilizing a suspension of microparticles is provided comprising an oil-in-water emulsion of an aqueous phase and an organic phase where the organic phase has a freezing point of about or higher than the freezing point of the aqueous phase. When frozen and dried with a suspension of microparticles, the organic phase is substantially removed and a dry formulation is formed of discrete microparticles substantially free of aggregates.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: November 19, 2002
    Assignee: Point Biomedical Corporation
    Inventors: Robert E. Short, Thomas B. Ottoboni
  • Microparticles useful as ultrasonic contrast agents and for delivery of drugs into the bloodstream
    Publication number: 20010012522
    Abstract: Microparticles are provided comprising a shell of an outer layer of a biologically compatible material and an inner layer of biodegradable polymer. The core of the microparticles contain a gas, liquid or solid for use in drug delivery or as a contrast agent for ultrasonic contrast imaging. The microparticles are capable of passing through the capillary systems of a subject.
    Type: Application
    Filed: January 11, 2001
    Publication date: August 9, 2001
    Inventors: Thomas B. Ottoboni, Robert E. Short, Ronald K. Yamamoto