Patents by Inventor Robert E. Tigelaar

Robert E. Tigelaar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-INFLAMMATORY AND WOUND HEALING EFFECTS OF LYMPHOID THYMOSIN B-4
    Publication number: 20090317457
    Abstract: The invention relates to a method of treating inflammatory conditions in a subject comprising administering to a subject a composition comprising a lymphoid thymosin-?4 polypeptide or a functional lymphoid thymosin-?4 polypeptide variant. The invention also provides a method of promoting wound healing in a subject comprising administering to the subject a composition comprising a lymphoid thymosin-?4 polypeptide or a functional lymphoid thymosin-?4 polypeptide variant. The invention also relates to methods of treating the above mentioned conditions in a subject comprising administering to the subject a nucleic acid encoding a lymphoid thymosin-?4 polypeptide or a functional lymphoid thymosin-?4 polypeptide variant. The invention also relates to pharmaceutical compositions comprising a lymphoid thymosin-?4 polypeptide or a functional lymphoid thymosin-?4 polypeptide variant, or salt thereof, and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: May 22, 2009
    Publication date: December 24, 2009
    Applicants: Yale University, King's College London
    Inventors: Michael Girardi, Robert E. Tigelaar, Michael A. Sherling, John Shires, Adrian C. Hayday, Efstathios Theodoridis
  • Specific immune system modulation
    Patent number: 6355238
    Abstract: Methods and pharmaceutical compositions for modifying the immune response of a mammal to a specific antigen are provided. The methods include treating an antigen presenting cell to enhance expression of a major histocompatibility complex molecule and reacting the treated antigen presenting cell with the antigen extracorporeally to form an antigen-associated antigen presenting cell.
    Type: Grant
    Filed: March 21, 1997
    Date of Patent: March 12, 2002
    Assignee: Yale University
    Inventors: Richard L. Edelson, Francis P. Gasparro, Robert E. Tigelaar
  • Specific immune system modulation
    Patent number: 5651993
    Abstract: Methods and pharmaceutical compositions for modifying the immune response of a mammal to a specific antigen are provided. The methods include treating an antigen presenting cell to enhance expression of a major histocompatibility complex molecule and reacting the treated antigen presenting cell with the antigen extracorporeally to form an antigen-associated antigen presenting cell.
    Type: Grant
    Filed: November 18, 1992
    Date of Patent: July 29, 1997
    Assignee: Yale University
    Inventors: Richard L. Edelson, Francis P. Gasparro, Robert E. Tigelaar