Patents by Inventor Robert E. W. Hancock

Robert E. W. Hancock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200032321
    Abstract: A method of diagnosing severe sepsis prior to definitive clinical diagnosis. A pattern of gene expression that correlates strongly with a future diagnosis of severe sepsis and organ failure was identified in patients who had their blood drawn at first clinical presentation. The methods comprise identifying a pattern of two or more polynucleotides, whereby the altered expression of these polynucleotides correlates with prospective and actual sepsis. Also methods of identifying agents for treating sepsis based on the characteristics of this gene expression pattern are provided.
    Type: Application
    Filed: February 19, 2019
    Publication date: January 30, 2020
    Inventor: Robert E.W. Hancock
  • Publication number: 20190315823
    Abstract: The present invention relates generally to peptides and more specifically to anti-biofilm and immunomodulatory peptides.
    Type: Application
    Filed: April 24, 2019
    Publication date: October 17, 2019
    Applicant: The University of British Columbia
    Inventors: Robert E.W. Hancock, Cesar de la Fuente Nunez, Jason Kindrachuk, Havard Jenssen, Joerg Overhage, Evan Haney
  • Patent number: 9707282
    Abstract: The present invention relates generally to peptides and more specifically to antimicrobial and immunomodulatory host defense peptides.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: July 18, 2017
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Robert E. W. Hancock, Kai Hilpert, Artem Cherkasov, Christopher Fjell
  • Publication number: 20170073734
    Abstract: A method of diagnosing severe sepsis prior to definitive clinical diagnosis. A pattern of gene expression that correlates strongly with a future diagnosis of severe sepsis and organ failure was identified in patients who had their blood drawn at first clinical presentation. The methods comprise identifying a pattern of two or more polynucleotides, whereby the altered expression of these polynucleotides correlates with prospective and actual sepsis. Also methods of identifying agents for treating sepsis based on the characteristics of this gene expression pattern are provided.
    Type: Application
    Filed: March 13, 2015
    Publication date: March 16, 2017
    Inventors: Robert E. W. Hancock, Olga M. Pena Serrato, David G. Hancock, John Boyd
  • Publication number: 20160289287
    Abstract: The present invention relates generally to peptides and more specifically to anti-biofilm and immunomodulatory peptides.
    Type: Application
    Filed: August 27, 2014
    Publication date: October 6, 2016
    Applicant: The University of British Columbia
    Inventors: Robert E.W. Hancock, Cesar de la Fuente Nunez, Jason Kindrachuk, Havard Jenssen, Joerg Overhage, Evan Haney
  • Publication number: 20150315240
    Abstract: The present invention relates generally to peptides and more specifically to antimicrobial and immunomodulatory host defense peptides.
    Type: Application
    Filed: April 10, 2015
    Publication date: November 5, 2015
    Inventors: Robert E.W. Hancock, Kai Hilpert, Artem Cherkasov, Christopher Fjell
  • Patent number: 9017656
    Abstract: The present invention relates generally to peptides and more specifically to antimicrobial and immunomodulatory host defense peptides.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: April 28, 2015
    Assignee: The University of British Columbia
    Inventors: Robert E. W. Hancock, Kai Hilpert, Artem Cherkasov, Christopher Fjell
  • Publication number: 20130266597
    Abstract: The present invention relates generally to peptides and more specifically to antimicrobial and immunomodulatory host defense peptides.
    Type: Application
    Filed: December 21, 2012
    Publication date: October 10, 2013
    Inventors: Robert E.W. Hancock, Kai Hilpert, Artem Cherkasov, Christopher Fjell
  • Patent number: 8343475
    Abstract: The present invention relates generally to peptides and more specifically to antimicrobial and immunomodulatory host defense peptides.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: January 1, 2013
    Assignee: The University of British Columbia
    Inventors: Robert E. W. Hancock, Kai Hilpert, Artem Cherkasov, Christopher Fjell
  • Patent number: 8252737
    Abstract: Disclosed herein are novel antimicrobial peptides with useful, improved, or superior properties such as antimicrobial activity, desirable levels of hemolytic activity, and therapeutic index against a broad range of microorganisms including gram-negative and gram-positive bacteria and other organisms having a cellular or structural component of a lipid bilayer membrane. Also provided are methods of making and using such peptides to control microbial growth and in pharmaceutical compositions for treatment or prevention of infections caused by such microorganisms. Certain peptides are disclosed utilizing a structure-based rational design relating to an antimicrobial peptide, V681, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face. Also disclosed are peptides with one or more amino acids in the D configuration, including peptides with all amino acids in the D configuration.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: August 28, 2012
    Assignee: The Regents of the University of Colorado
    Inventors: Robert S. Hodges, Yuxin Chen, Michael Vasil, Robert E. W. Hancock, Susan W. Farmer
  • Publication number: 20110236429
    Abstract: The present invention relates generally to peptides and more specifically to antimicrobial and immunomodulatory host defense peptides.
    Type: Application
    Filed: August 21, 2007
    Publication date: September 29, 2011
    Inventors: Robert E. W. Hancock, Kai Hilpert, Artem Cherkasov, Christopher Fjell
  • Patent number: 7687454
    Abstract: A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbe or microbial components in the presence or absence of a cationic peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absence of the peptide, wherein the pattern in the presence of the peptide represents inhibition of an inflammatory or septic response. Also included are compounds and agents identified by the methods of the invention. In another aspect, the invention provides methods and compounds for enhancing innate immunity in a subject.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: March 30, 2010
    Assignee: The University of British Columbia
    Inventors: Robert E. W. Hancock, B. Brett Finlay, Monisha Gough Scott, Dawn Bowdish, Carrie Melissa Rosenberger, Jon-Paul Steven Powers
  • Patent number: 7507787
    Abstract: A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbe or microbial components in the presence or absence of a cationic peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absence of the peptide, wherein the pattern in the presence of the peptide represents inhibition of an inflammatory or septic response. Also included are compounds and agents identified by the methods of the invention. In another aspect, the invention provides methods and compounds for enhancing innate immunity in a subject.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: March 24, 2009
    Assignee: The University of British Columbia
    Inventors: Robert E. W. Hancock, B. Brett Finlay, Monisha Gough Scott, Dawn Bowdish, Carrie Melissa Rosenberger, Jon-Paul Steven Powers
  • Publication number: 20090005300
    Abstract: Disclosed herein are novel antimicrobial peptides with useful, improved, or superior properties such as antimicrobial activity, desirable levels of hemolytic activity, and therapeutic index against a broad range of microorganisms including gram-negative and gram-positive bacteria and other organisms having a cellular or structural component of a lipid bilayer membrane. Also provided are methods of making and using such peptides to control microbial growth and in pharmaceutical compositions for treatment or prevention of infections caused by such microorganisms. Certain peptides are disclosed utilizing a structure-based rational design relating to an antimicrobial peptide, V681, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face. Also disclosed are peptides with one or more amino acids in the D configuration, including peptides with all amino acids in the D configuration.
    Type: Application
    Filed: December 15, 2005
    Publication date: January 1, 2009
    Applicants: The Regents of the University of Colorado, The University of British Columbia
    Inventors: Robert S. Hodges, Yuxin Chen, Michael Vasil, Robert E. W. Hancock, Susan W. Farmer
  • Publication number: 20080207522
    Abstract: A novel class of peptides having antimicrobial activity is provided. Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. Pharmaceutical compositions comprising the novel class of peptides are also provided.
    Type: Application
    Filed: November 14, 2005
    Publication date: August 28, 2008
    Inventors: Robert E.W. Hancock, Kai Hilpert
  • Patent number: 7390873
    Abstract: A novel class of cationic peptides having antimicrobial activity is disclosed. These peptides can be encompassed by the formulas: X1X1PX2X3X2P(X2X2P)nX2X3(X5)0; (SEQ ID NO:23) X1X1PX2X3X4(X5)rPX2X3X3; (SEQ ID NO:24) X1X1X3(PW)uX3X2X5X2X2X5X2(X5)0; and (SEQ ID NO:25) X1X1X3X3X2P(X2X2P)nX2(X5)m; (SEQ ID NO:26) wherein: m is 1 to 5; n is 1 or 2; o is 2 to 5; r is 0 to 8; u is 0 or 1; X1 is Isoleucine, Leucine, Valine, Phenylalanine, Tyrosine, Tryptophan or Methionine; X2 represents Tryptophan or Phenylalanine X3 represents Arginine or Lysine; X4 represents Tryptophan or Lysine; and X5 represents Phenylalanine, Tryptophan, Arginine, Lysine, or Proline. The invention also provides a method of producing a cationic peptide variant having antimicrobial activity.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: June 24, 2008
    Assignee: University of British Columbia
    Inventors: Timothy J. Falla, Robert E. W. Hancock, Monisha Gough
  • Patent number: 6906035
    Abstract: A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include NH2-KWKSFIKKLTTAVKKVLTTGLPALIS-COOH (SEQ ID NO:1) and NH2-KWKSFIKKLTSAAKKVVTTAKPLISS-COOH (SEQ ID NO:2). Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxemia in a subject.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: June 14, 2005
    Assignee: The University of British Columbia
    Inventors: Robert E. W. Hancock, Nedra Karunaratne
  • Patent number: 6818407
    Abstract: A novel class of cationic peptides having antimicrobial activity is provided. Exemplary peptides of the invention include KWKSFIKKLTSAAKKVVTTAKPLALIS (SEQ ID NO:3) and KGWGSFFKKAAHVGKHVGKAALTHYL (SEQ ID NO:15). Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. Such methods are useful for the treatment of respiratory infections, such as in cystic fibrosis patients. Such methods are further useful for accelerating wound healing.
    Type: Grant
    Filed: July 17, 2001
    Date of Patent: November 16, 2004
    Assignee: The University of British Columbia
    Inventors: Robert E. W. Hancock, Monisha A. Gough, Aleksander Patrzykat, Donald Woods, Xiaoyan Jia
  • Publication number: 20040186272
    Abstract: A novel class of cationic peptides having antimicrobial activity is provided. Exemplary peptides of the invention include KWKSFIKKLTSAAKKVVTTAKPLALIS (SEQ ID NO:3) and KGWGSFFKKAAHVGKHVGKAALTHYL (SEQ ID NO:15). Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. Such methods are useful for the treatment of respiratory infections, such as in cystic fibrosis patients. Such methods are further useful for accelerating wound healing.
    Type: Application
    Filed: April 12, 2004
    Publication date: September 23, 2004
    Inventors: Robert E. W. Hancock, Monisha A. Gough, Aleksander Patrzykat, Donald Woods, Xiaoyan Jia
  • Publication number: 20040180038
    Abstract: A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbe or microbial components in the presence or absence of a cationic peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absence of the peptide, wherein the pattern in the presence of the peptide represents inhibition of an inflammatory or septic response. Also included are compounds and agents identified by the methods of the invention. In another aspect, the invention provides methods and compounds for enhancing innate immunity in a subject.
    Type: Application
    Filed: September 12, 2003
    Publication date: September 16, 2004
    Inventors: Robert E. W. Hancock, B. Brett Finlay, Monisha Gough Scott, Dawn Bowdish, Carrie Melissa Rosenberger, Jon-Paul Steven Powers