Patents by Inventor Robert E. W. Hancock
Robert E. W. Hancock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11851717Abstract: A method of diagnosing severe sepsis prior to definitive clinical diagnosis. A pattern of gene expression that correlates strongly with a future diagnosis of severe sepsis and organ failure was identified in patients who had their blood drawn at first clinical presentation. The methods comprise identifying a pattern of two or more polynucleotides, whereby the altered expression of these polynucleotides correlates with prospective and actual sepsis. Also methods of identifying agents for treating sepsis based on the characteristics of this gene expression pattern are provided.Type: GrantFiled: February 19, 2019Date of Patent: December 26, 2023Inventor: Robert E. W. Hancock
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Publication number: 20200032321Abstract: A method of diagnosing severe sepsis prior to definitive clinical diagnosis. A pattern of gene expression that correlates strongly with a future diagnosis of severe sepsis and organ failure was identified in patients who had their blood drawn at first clinical presentation. The methods comprise identifying a pattern of two or more polynucleotides, whereby the altered expression of these polynucleotides correlates with prospective and actual sepsis. Also methods of identifying agents for treating sepsis based on the characteristics of this gene expression pattern are provided.Type: ApplicationFiled: February 19, 2019Publication date: January 30, 2020Inventor: Robert E.W. Hancock
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Publication number: 20190315823Abstract: The present invention relates generally to peptides and more specifically to anti-biofilm and immunomodulatory peptides.Type: ApplicationFiled: April 24, 2019Publication date: October 17, 2019Applicant: The University of British ColumbiaInventors: Robert E.W. Hancock, Cesar de la Fuente Nunez, Jason Kindrachuk, Havard Jenssen, Joerg Overhage, Evan Haney
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Patent number: 9707282Abstract: The present invention relates generally to peptides and more specifically to antimicrobial and immunomodulatory host defense peptides.Type: GrantFiled: April 10, 2015Date of Patent: July 18, 2017Assignee: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Robert E. W. Hancock, Kai Hilpert, Artem Cherkasov, Christopher Fjell
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Publication number: 20170073734Abstract: A method of diagnosing severe sepsis prior to definitive clinical diagnosis. A pattern of gene expression that correlates strongly with a future diagnosis of severe sepsis and organ failure was identified in patients who had their blood drawn at first clinical presentation. The methods comprise identifying a pattern of two or more polynucleotides, whereby the altered expression of these polynucleotides correlates with prospective and actual sepsis. Also methods of identifying agents for treating sepsis based on the characteristics of this gene expression pattern are provided.Type: ApplicationFiled: March 13, 2015Publication date: March 16, 2017Inventors: Robert E. W. Hancock, Olga M. Pena Serrato, David G. Hancock, John Boyd
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Publication number: 20160289287Abstract: The present invention relates generally to peptides and more specifically to anti-biofilm and immunomodulatory peptides.Type: ApplicationFiled: August 27, 2014Publication date: October 6, 2016Applicant: The University of British ColumbiaInventors: Robert E.W. Hancock, Cesar de la Fuente Nunez, Jason Kindrachuk, Havard Jenssen, Joerg Overhage, Evan Haney
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Publication number: 20150315240Abstract: The present invention relates generally to peptides and more specifically to antimicrobial and immunomodulatory host defense peptides.Type: ApplicationFiled: April 10, 2015Publication date: November 5, 2015Inventors: Robert E.W. Hancock, Kai Hilpert, Artem Cherkasov, Christopher Fjell
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Patent number: 9017656Abstract: The present invention relates generally to peptides and more specifically to antimicrobial and immunomodulatory host defense peptides.Type: GrantFiled: December 21, 2012Date of Patent: April 28, 2015Assignee: The University of British ColumbiaInventors: Robert E. W. Hancock, Kai Hilpert, Artem Cherkasov, Christopher Fjell
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Publication number: 20130266597Abstract: The present invention relates generally to peptides and more specifically to antimicrobial and immunomodulatory host defense peptides.Type: ApplicationFiled: December 21, 2012Publication date: October 10, 2013Inventors: Robert E.W. Hancock, Kai Hilpert, Artem Cherkasov, Christopher Fjell
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Patent number: 8343475Abstract: The present invention relates generally to peptides and more specifically to antimicrobial and immunomodulatory host defense peptides.Type: GrantFiled: August 21, 2007Date of Patent: January 1, 2013Assignee: The University of British ColumbiaInventors: Robert E. W. Hancock, Kai Hilpert, Artem Cherkasov, Christopher Fjell
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Patent number: 8252737Abstract: Disclosed herein are novel antimicrobial peptides with useful, improved, or superior properties such as antimicrobial activity, desirable levels of hemolytic activity, and therapeutic index against a broad range of microorganisms including gram-negative and gram-positive bacteria and other organisms having a cellular or structural component of a lipid bilayer membrane. Also provided are methods of making and using such peptides to control microbial growth and in pharmaceutical compositions for treatment or prevention of infections caused by such microorganisms. Certain peptides are disclosed utilizing a structure-based rational design relating to an antimicrobial peptide, V681, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face. Also disclosed are peptides with one or more amino acids in the D configuration, including peptides with all amino acids in the D configuration.Type: GrantFiled: December 15, 2005Date of Patent: August 28, 2012Assignee: The Regents of the University of ColoradoInventors: Robert S. Hodges, Yuxin Chen, Michael Vasil, Robert E. W. Hancock, Susan W. Farmer
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Publication number: 20110236429Abstract: The present invention relates generally to peptides and more specifically to antimicrobial and immunomodulatory host defense peptides.Type: ApplicationFiled: August 21, 2007Publication date: September 29, 2011Inventors: Robert E. W. Hancock, Kai Hilpert, Artem Cherkasov, Christopher Fjell
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Patent number: 7687454Abstract: A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbe or microbial components in the presence or absence of a cationic peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absence of the peptide, wherein the pattern in the presence of the peptide represents inhibition of an inflammatory or septic response. Also included are compounds and agents identified by the methods of the invention. In another aspect, the invention provides methods and compounds for enhancing innate immunity in a subject.Type: GrantFiled: September 12, 2003Date of Patent: March 30, 2010Assignee: The University of British ColumbiaInventors: Robert E. W. Hancock, B. Brett Finlay, Monisha Gough Scott, Dawn Bowdish, Carrie Melissa Rosenberger, Jon-Paul Steven Powers
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Patent number: 7507787Abstract: A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbe or microbial components in the presence or absence of a cationic peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absence of the peptide, wherein the pattern in the presence of the peptide represents inhibition of an inflammatory or septic response. Also included are compounds and agents identified by the methods of the invention. In another aspect, the invention provides methods and compounds for enhancing innate immunity in a subject.Type: GrantFiled: December 2, 2002Date of Patent: March 24, 2009Assignee: The University of British ColumbiaInventors: Robert E. W. Hancock, B. Brett Finlay, Monisha Gough Scott, Dawn Bowdish, Carrie Melissa Rosenberger, Jon-Paul Steven Powers
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Publication number: 20090005300Abstract: Disclosed herein are novel antimicrobial peptides with useful, improved, or superior properties such as antimicrobial activity, desirable levels of hemolytic activity, and therapeutic index against a broad range of microorganisms including gram-negative and gram-positive bacteria and other organisms having a cellular or structural component of a lipid bilayer membrane. Also provided are methods of making and using such peptides to control microbial growth and in pharmaceutical compositions for treatment or prevention of infections caused by such microorganisms. Certain peptides are disclosed utilizing a structure-based rational design relating to an antimicrobial peptide, V681, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face. Also disclosed are peptides with one or more amino acids in the D configuration, including peptides with all amino acids in the D configuration.Type: ApplicationFiled: December 15, 2005Publication date: January 1, 2009Applicants: The Regents of the University of Colorado, The University of British ColumbiaInventors: Robert S. Hodges, Yuxin Chen, Michael Vasil, Robert E. W. Hancock, Susan W. Farmer
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Publication number: 20080207522Abstract: A novel class of peptides having antimicrobial activity is provided. Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. Pharmaceutical compositions comprising the novel class of peptides are also provided.Type: ApplicationFiled: November 14, 2005Publication date: August 28, 2008Inventors: Robert E.W. Hancock, Kai Hilpert
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Patent number: 7390873Abstract: A novel class of cationic peptides having antimicrobial activity is disclosed. These peptides can be encompassed by the formulas: X1X1PX2X3X2P(X2X2P)nX2X3(X5)0; (SEQ ID NO:23) X1X1PX2X3X4(X5)rPX2X3X3; (SEQ ID NO:24) X1X1X3(PW)uX3X2X5X2X2X5X2(X5)0; and (SEQ ID NO:25) X1X1X3X3X2P(X2X2P)nX2(X5)m; (SEQ ID NO:26) wherein: m is 1 to 5; n is 1 or 2; o is 2 to 5; r is 0 to 8; u is 0 or 1; X1 is Isoleucine, Leucine, Valine, Phenylalanine, Tyrosine, Tryptophan or Methionine; X2 represents Tryptophan or Phenylalanine X3 represents Arginine or Lysine; X4 represents Tryptophan or Lysine; and X5 represents Phenylalanine, Tryptophan, Arginine, Lysine, or Proline. The invention also provides a method of producing a cationic peptide variant having antimicrobial activity.Type: GrantFiled: March 28, 2003Date of Patent: June 24, 2008Assignee: University of British ColumbiaInventors: Timothy J. Falla, Robert E. W. Hancock, Monisha Gough
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Patent number: 6906035Abstract: A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include NH2-KWKSFIKKLTTAVKKVLTTGLPALIS-COOH (SEQ ID NO:1) and NH2-KWKSFIKKLTSAAKKVVTTAKPLISS-COOH (SEQ ID NO:2). Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxemia in a subject.Type: GrantFiled: October 15, 2002Date of Patent: June 14, 2005Assignee: The University of British ColumbiaInventors: Robert E. W. Hancock, Nedra Karunaratne
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Patent number: 6818407Abstract: A novel class of cationic peptides having antimicrobial activity is provided. Exemplary peptides of the invention include KWKSFIKKLTSAAKKVVTTAKPLALIS (SEQ ID NO:3) and KGWGSFFKKAAHVGKHVGKAALTHYL (SEQ ID NO:15). Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. Such methods are useful for the treatment of respiratory infections, such as in cystic fibrosis patients. Such methods are further useful for accelerating wound healing.Type: GrantFiled: July 17, 2001Date of Patent: November 16, 2004Assignee: The University of British ColumbiaInventors: Robert E. W. Hancock, Monisha A. Gough, Aleksander Patrzykat, Donald Woods, Xiaoyan Jia
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Publication number: 20040186272Abstract: A novel class of cationic peptides having antimicrobial activity is provided. Exemplary peptides of the invention include KWKSFIKKLTSAAKKVVTTAKPLALIS (SEQ ID NO:3) and KGWGSFFKKAAHVGKHVGKAALTHYL (SEQ ID NO:15). Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. Such methods are useful for the treatment of respiratory infections, such as in cystic fibrosis patients. Such methods are further useful for accelerating wound healing.Type: ApplicationFiled: April 12, 2004Publication date: September 23, 2004Inventors: Robert E. W. Hancock, Monisha A. Gough, Aleksander Patrzykat, Donald Woods, Xiaoyan Jia