Patents by Inventor Robert E. Zipkin

Robert E. Zipkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sphingosine kinase type 1 inhibitors, compositions and processes for using same
    Patent number: 8372888
    Abstract: Provided are novel compositions which uniquely inhibit sphingosine kinase Type 1 (SphK1) and which are useful in a number of applications including killing or damaging cancer cells, inducing apoptosis, inhibiting growth, metastasis and development of chemoresistance in cancer cells, leukemia, increasing the effectiveness of anti-cancer agents, attenuating immune reactivity, inhibiting survival signaling in cancer cells, and reducing symptoms of multiple sclerosis.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: February 12, 2013
    Assignee: Enzo Therapeutics, Inc.
    Inventors: Robert E. Zipkin, Sarah Spiegel, Jeffrey Kroll Adams
  • Compositions and Methods for Selectively Activating Human Sirtuins
    Publication number: 20120172340
    Abstract: Methods for identifying selective activators of SIRT5 and/or SIRT1 and methods for using these selective activators in the modulation of SIRT5 and/or SIRT1 are provided.
    Type: Application
    Filed: October 7, 2010
    Publication date: July 5, 2012
    Applicant: BIOMOL International L.P.
    Inventors: Konrad T. Howitz, Robert E. Zipkin
  • COMPOSITIONS FOR MANIPULATING THE LIFESPAN AND STRESS RESPONSE OF CELLS AND ORGANISMS
    Publication number: 20100035885
    Abstract: Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.
    Type: Application
    Filed: June 8, 2009
    Publication date: February 11, 2010
    Applicants: President and Fellows of Harvard College, BIOMOL International L.P.
    Inventors: David A. Sinclair, Konrad T. Howitz, Robert E. Zipkin, Kevin J. Bitterman, Dudley W. Lamming
  • Compositions for manipulating the lifespan and stress response of cells and organisms
    Patent number: 7544497
    Abstract: Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.
    Type: Grant
    Filed: July 1, 2004
    Date of Patent: June 9, 2009
    Assignees: President and Fellows of Harvard College, Biomol International LP
    Inventors: David A. Sinclair, Konrad T. Howitz, Robert E. Zipkin, Kevin J. Bitterman, Dudley W. Lamming