Patents by Inventor Robert Edgar Colborn
Robert Edgar Colborn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190001001Abstract: Design and use of an administered drug in the form of a nanoparticle or molecule is described. In certain examples, the nanoparticle has a core and a shell surrounding the core. The core may be configured or designed to provide useful X-ray attenuating properties, gamma ray emission properties, magnetic properties, or therapeutic effects. In certain aspects, the nanoparticle or molecule is sized so as to either distribute from or remain in the blood pool, while still being eliminated by the kidneys.Type: ApplicationFiled: July 3, 2017Publication date: January 3, 2019Inventors: Paul Francis Fitzgerald, Michael Ernest Marino, Peter Michael Edic, Daniel Eugene Meyer, Peter J. Bonitatibus, Jr., Robert Edgar Colborn, Benjamin Ming-Yueh Yeh
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Publication number: 20190001002Abstract: Design and use of an administered drug in the form of a nanoparticle or molecule is described. In certain examples, the nanoparticle has a core and a shell surrounding the core. The core may be configured or designed to provide useful X-ray attenuating properties, gamma ray emission properties, magnetic properties, or therapeutic effects. In certain aspects, the nanoparticle or molecule is sized so as to either distribute from or remain in the blood pool, while still being eliminated by the kidneys.Type: ApplicationFiled: July 3, 2018Publication date: January 3, 2019Inventors: Paul Francis Fitzgerald, Michael Ernest Marino, Peter Michael Edic, Daniel Eugene Meyer, Peter J. Bonitatibus, JR., Robert Edgar Colborn, Benjamin Ming-Yueh Yeh
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Patent number: 9585974Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.Type: GrantFiled: June 20, 2016Date of Patent: March 7, 2017Assignee: General Electric CompanyInventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, Jr., Andrew Soliz Torres
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Publication number: 20170009118Abstract: A method and apparatus for generating latent heat at low temperatures using an exothermic salt crystallization reaction in a supersaturated solution. The method and apparatus includes a supersaturated solution including a salt-based solute in a solvent. In an embodiment, the supersaturated solution is comprised of a salt-based solute of at least 50 wt. % sodium acetate trihydrate in a solvent of 70 vol. % ethylene glycol and 30 vol. % water. The supersaturated solution remains stable at a temperature below a melting point of the salt-based solute and is triggered to crystallize in a controlled manner to generate latent heat. The method and apparatus further including an actuation component, in fluid communication with a lubricating fluid, to initiate an exothermic crystallization response in the supersaturated solution. The supersaturated solution is suitable for use in a heat exchanger apparatus of an engine.Type: ApplicationFiled: July 10, 2015Publication date: January 12, 2017Inventors: Robert Edgar Colborn, William Dwight Gerstler, Carlos Enrique Diaz, Maria Rocco LaTorre
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Publication number: 20160296641Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.Type: ApplicationFiled: June 20, 2016Publication date: October 13, 2016Inventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, JR., Andrew Soliz Torres
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Patent number: 9399075Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.Type: GrantFiled: April 29, 2013Date of Patent: July 26, 2016Assignee: General Electric CompanyInventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, Jr., Andrew Soliz Torres, Brian Christopher Bales, Michael Ernest Marino, Bruce Allan Hay, Amit Mohan Kulkarni
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Patent number: 9373433Abstract: A method of making a nanocomposite permanent magnet is provided. The method comprises applying an extreme shear deformation to hard magnetic phase nanoparticles and soft magnetic phase nanoparticles to align at least a portion of the hard phase magnetic particles and to produce a nanocomposite permanent magnet.Type: GrantFiled: June 29, 2012Date of Patent: June 21, 2016Assignee: General Electric CompanyInventors: Francis Johnson, Robert Edgar Colborn, Judson Sloan Marte, Peter John Bonitatibus, Jr., Binil Itty Ipe Kandapallil, Mohammed Haouaoui, Christina Chen
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Patent number: 9251938Abstract: A method of synthesizing magnetic nanoparticles comprising soft magnetic phases is provided, wherein the method comprises degassing a first mixture at a temperature in a range from about 80° C. to 130° C. The first mixture comprises a solvent, a compound comprising iron, cobalt, or combinations thereof dissolved in the solvent, and an organic component comprising a fatty acid or an amine. Degassing the first mixture is followed by adding a capping ligand to the first mixture under inert atmosphere to form a second mixture; adding a reducing agent to the second mixture at a temperature in a processing temperature range from about 250° C. to about 350° C. to form a third mixture; and incubating the third mixture at a temperature within the processing temperature range to form nanoparticles comprising a soft magnetic phase.Type: GrantFiled: March 7, 2013Date of Patent: February 2, 2016Assignee: General Electric CompanyInventors: Binil Itty Ipe Kandapallil, Robert Edgar Colborn, Peter John Bonitatibus, Jr., Francis Johnson
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Patent number: 9149545Abstract: The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites. Included herein are methods for forming such agents, comprising forming an ensemble of core/shell nanoparticles, wherein the mean diameter of the ensemble of core/shell nanoparticles is selected so as to render the nanoparticles in the ensemble substantially clearable by a mammalian kidney.Type: GrantFiled: November 24, 2008Date of Patent: October 6, 2015Assignee: General Electric CompanyInventors: Peter John Bonitatibus, Jr., David Cheney deMoulpied, Andrew Soliz Torres, Amit Mohan Kulkarni, Robert Edgar Colborn, Paul William Buckley
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Publication number: 20140252264Abstract: A method of synthesizing magnetic nanoparticles comprising soft magnetic phases is provided, wherein the method comprises degassing a first mixture at a temperature in a range from about 80° C. to 130° C. The first mixture comprises a solvent, a compound comprising iron, cobalt, or combinations thereof dissolved in the solvent, and an organic component comprising a fatty acid or an amine. Degassing the first mixture is followed by adding a capping ligand to the first mixture under inert atmosphere to form a second mixture; adding a reducing agent to the second mixture at a temperature in a processing temperature range from about 250° C. to about 350° C. to form a third mixture; and incubating the third mixture at a temperature within the processing temperature range to form nanoparticles comprising a soft magnetic phase.Type: ApplicationFiled: March 7, 2013Publication date: September 11, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Binil Itty Ipe Kandapallil, Robert Edgar Colborn, Peter John Bonitatibus, JR., Francis Johnson
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Patent number: 8821838Abstract: The present invention provides a trialkoxysilane having structure I wherein R1 is independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group; R4 is a C1-C5 aliphatic radical, a C7-C12 aromatic radical, or a C5-C10 cycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; t is 0, 1 or 2; and X? represents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.Type: GrantFiled: August 23, 2012Date of Patent: September 2, 2014Assignee: General Electric CompanyInventors: Peter John Bonitatibus, Jr., Matthew David Butts, Robert Edgar Colborn, Andrew Soliz Torres
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Patent number: 8728529Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.Type: GrantFiled: December 29, 2008Date of Patent: May 20, 2014Assignee: General Electric CompanyInventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, Jr., Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michael Ernest Marino
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Patent number: 8728440Abstract: The present invention provides a trialkoxysilanes having structure I wherein R1 and R2 are independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group; R4 is a C1-C5 aliphatic radical, a C7-C12 aromatic radical, or a C5-C10 cycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; and X? represents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.Type: GrantFiled: August 23, 2012Date of Patent: May 20, 2014Assignee: General Electric CompanyInventors: Matthew David Butts, Peter John Bonitatibus, Jr., Robert Edgar Colborn, Andrew Soliz Torres
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Publication number: 20140056819Abstract: The present invention provides a trialkoxysilanes having structure I wherein R1 and R2 are independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group; R4 is a C1-C5 aliphatic radical, a C7-C12 aromatic radical, or a C5-C10 cycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; and X? represents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.Type: ApplicationFiled: August 23, 2012Publication date: February 27, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Matthew David Butts, Peter John Bonitatibus, JR., Robert Edgar Colborn, Andrew Soliz Torres
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Publication number: 20140056821Abstract: The present invention provides a trialkoxysilane having structure I wherein R1 is independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group; R4 is a C1-C5 aliphatic radical, a C7-C12 aromatic radical, or a C5-C10 cycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; t is 0, 1 or 2; and X? represents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.Type: ApplicationFiled: August 23, 2012Publication date: February 27, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Peter John Bonitatibus, JR., Matthew David Butts, Robert Edgar Colborn, Andrew Soliz Torres
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Publication number: 20140002220Abstract: A method of making a nanocomposite permanent magnet is provided. The method comprises applying an extreme shear deformation to hard magnetic phase nanoparticles and soft magnetic phase nanoparticles to align at least a portion of the hard phase magnetic particles and to produce a nanocomposite permanent magnet.Type: ApplicationFiled: June 29, 2012Publication date: January 2, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Francis Johnson, Robert Edgar Colborn, Judson Sloan Marte, Peter John Bonitatibus, JR., Binil Itty Ipe Kandapallil, Mohammed Haouaoui, Christina Chen
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Patent number: 8586501Abstract: According to various embodiments, a catalyst composition includes a catalytic metal secured to a porous substrate. The substrate has pores that are templated. The substrate is a product of adding a substrate precursor to a water-in-oil microemulsion including a catalytic metal salt, a solvent, a templating agent, and water.Type: GrantFiled: October 4, 2010Date of Patent: November 19, 2013Assignee: General Electric CompanyInventors: Larry Neil Lewis, Robert Edgar Colborn, Ashish Balkrishna Mhadeshwar, Dan Hancu
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Patent number: 8580464Abstract: The invention relates generally to optical data storage media, and more specifically, to holographic storage media. In one embodiment, an optical storage medium composition includes a polymer matrix. Disposed within the polymer matrix is a reactant capable of undergoing a modification that alters the refractive index of the composition upon receiving an energy transfer from an excited sensitizer. A non-linear sensitizer is also disposed within the polymer matrix, and the sensitizer includes a metal-substituted subphthalocyanine (M-sub-PC) reverse saturable absorber configured to become excited upon exposure to light beyond an intensity threshold at approximately 405 nm and configured to transfer energy to the reactant.Type: GrantFiled: November 17, 2011Date of Patent: November 12, 2013Assignee: General Electric CompanyInventors: Arunkumar Natarajan, Patrick Joseph McCloskey, Kwok Pong Chan, Evgenia Mikhailovna Kim, Robert Edgar Colborn, Eugene Pauling Boden
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Patent number: 8574549Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.Type: GrantFiled: December 29, 2008Date of Patent: November 5, 2013Assignee: General Electric CompanyInventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, Jr., Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michacl Ernest Marino
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Patent number: 8536298Abstract: A process for preparing polyimide resins comprises stirring a diamine and a dianhydride in a solvent to form a slurry; heating the slurry to a temperature sufficient for the diamine and dianhydride to react wherein the temperature is below the melting point of the dianhydride, below the melting point of the diamine, or below the melting points of the dianhydride and diamine; and reacting the diamine and dianhydride to form a polyimide having sufficient molecular weight to precipitate from the solvent.Type: GrantFiled: May 25, 2005Date of Patent: September 17, 2013Assignee: SABIC Innovative Platics IP B.V.Inventors: Philip L. Angermeier, Robert Edgar Colborn, Robert R. Gallucci, Paul Edward Howson, Tara Jane Mullen, Roy Ray Odle, Albert Santo Stella, John Morgan Whitney