Patents by Inventor Robert Edward Zelle

Robert Edward Zelle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carbamates and ureas as modifiers of multi-drug resistance
    Patent number: 5744485
    Abstract: The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer therapy.
    Type: Grant
    Filed: January 23, 1995
    Date of Patent: April 28, 1998
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Robert Edward Zelle, Matthew W. Harding
  • Tetralin compounds with improved MDR activity
    Patent number: 5726184
    Abstract: The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: March 10, 1998
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventor: Robert Edward Zelle