Abstract: Systems and methods for isolating applications associated with multiple tenants within a computing platform receive a request from a client associated with a tenant for running an application on a computing platform. Hosts connected to the platform are associated with a network address and configured to run applications associated with multiple tenants. A host is identified based at least in part on the request. One or more broadcast domain(s) including the identified hosts are generated. The broadcast domains are isolated in the network at a data link layer. A unique tenant identification number corresponding to the tenant is assigned to the broadcast domains. In response to launching the application on the host: the unique tenant identification number is assigned to the launched application and is added to the network address of the host; and the network address of the host is sent to the client associated with the tenant.

Abstract: A system and method for authenticating users of a data processing platform stores a mapping of a unique user platform identifier to multiple user identity provider identifiers associated with multiple realms for a same user. In some examples, the method includes receiving a request from a client device to establish an access session to perform one or more actions on data of the data processing platform and receiving, from at least one of the first external identity provider of the first realm or the second external identity provider of the second realm, a user identity provider identifier associated with the request. In certain examples, the method includes granting permission to perform the one or more actions on the data of the data processing platform based at least in part on the received user identity provider identifier.

Abstract: A method and system for serving assets is disclosed, comprising receiving an asset request to serve an asset, wherein the asset request originates at an application, and wherein the asset request comprises an advertisement of an asset to be served and a request for the network address of an asset server configured to serve the requested asset. The method further comprises causing a service discovery server to identify an asset server configured to serve the requested asset, and causing the requested asset to be served to the application.

Abstract: Provided are inhibitors of sphingosine kinase Type I that are useful in the treatment of neuropathic pain.

Abstract: A composition comprising a heat transfer portion and a lubricating portion, wherein the lubricating portion comprises one or more compounds according to formula (I) of the present disclosure, wherein W is H; Y is independently selected from the group consisting of F, Cl, Br and I; Z is independently selected from the group consisting of H, OH, (CW2)PCW3, CY3, OCW3, O(CW2)pCW3, OCW((CY2)mCY3)CWCW2, polyalkylene glycol and polyolester; n is an integer from 2 to 250; m is an integer from 0 to 3; and p is an integer from 0 to 9.

Abstract: The present disclosure provides compounds of formula (I), and preparation method thereof, wherein W is independently selected from the group consisting of H, F, Cl, Br and I; X is independently selected from the group consisting of H, F, Cl, Br, I, CW3 and OR on the basis that at least one X is OR; R is independently selected from the group consisting of C(O)CH2)m(CF2)nY and CW2C(CW2OC(O)(CH2)m(CF2)nY)3; m is an integer from 0 to 2;15 n is an integer from 2 to 8; Y is C(Z)3; and Z is independently selected from the group consisting of H, F, Cl, Br and I. Such compounds may be utilised as lubricants, for example in heat transfer compositions.

Abstract: A passenger seating installation for a vehicle comprises a front seat located adjacent a bulkhead and facing in a direction that is oblique to the direction of travel of the vehicle. The bulkhead includes a recess for receiving the head of a passenger in the front seat in the event of an accident. The recess is spaced apart from the front seat in the direction of travel and in a direction that is obliquely disposed with respect to the direction in which the seated passenger faces. The recess allows the front seat to be located closer to the bulkhead than would be the case in the absence of the recess, which can increase seat density in a seating area.

Abstract: An apparatus is configured for undersea use, such as for penetrating a seabed for forming a borehole therein, including with optional data acquisition and logging capabilities. A first or base module (12) of the apparatus is adapted for engaging the seabed. A first elevator (16) provides longitudinal movement of a second or upper module (14) relative to the base module (12) along a drilling axis. The relative movement of the upper and base modules may be used in the course of independently moving first (18) and second (20) rotary units along the drilling axis to cause a drill rod (R) and a drill casing (C) to penetrate the seabed such that the collapse of the borehole is avoided.

Abstract: A cladding element, for use in a building envelope, comprising a first face, a second face and a plurality of edges. One or more of the plurality of edges includes a mating feature configured to resist moisture passage between cladding elements when the cladding elements are installed on a wall or other structure. The cladding element can include one or more joint features to improve mating between the cladding elements, reduce labor costs, and facilitate moisture drainage from the cladding elements.

Abstract: Configurations are described for conducting minimally invasive medical interventions utilizing elongate instruments and assemblies thereof to stabilize and/or fixate a sacro-iliac joint. In one embodiment, a tool assembly may be advanced from a posterior approach into the SI junction and configured to create a defect defined at least in part by portions of both the sacrum and the ilium, the defect having a three dimensional shape defined in part by at least one noncircular cross sectional shape in a plane substantially perpendicular to the longitudinal axis of the tool assembly. After a defect is created, the tool assembly may be retracted and a prosthesis deployed into the defect.

Abstract: A composition comprising a heat transfer portion and a lubricating portion, wherein the lubricating portion comprises one or more compounds according to formula (I): wherein W is independently selected from the group consisting of H, F, Cl, Br and I; Y is independently selected from the group consisting of F, Cl, Br and I; Z is independently selected from the group consisting of H, OH, (CW2)PCW3, CY3, OCW3, O(CW2)pCW3, OCW((CY2)mCY3)CWCW2, polyalkylene glycol and polyolester; n is an integer from 2 to 250; m is an integer from 0 to 3; and p is an integer from 0 to 9.

Abstract: A composition comprising a heat transfer portion and a lubricating portion, wherein the lubricating portion comprises one or more compounds according to formula (I) of the present disclosure, wherein W is H; Y is independently selected from the group consisting of F, Cl, Br and I; Z is independently selected from the group consisting of H, OH, (CW2)PCW3, CY3, OCW3, 0(CW2)pCW3, OCW((CY2)mCY3)CWCW2, polyalkylene glycol and polyolester; n is an integer from 2 to 250; m is an integer from 0 to 3; and p is an integer from 0 to 9.

Abstract: A cladding element, for use in a building envelope, comprising a first face, a second face and a plurality of edges. One or more of the plurality of edges includes a mating feature configured to resist moisture passage between cladding elements when the cladding elements are installed on a wall or other structure. The mating features of each cladding element including one or more beveled edges designed to improve mating between the cladding elements and the overall aesthetic appearance of the mating interface between adjacent cladding elements when installed on a wall or other structure.

Abstract: Configurations are described for conducting minimally invasive medical interventions utilizing elongate instruments and assemblies thereof to stabilize and/or fixate a sacro-iliac joint. In one embodiment, a tool assembly may be advanced from a posterior approach into the SI junction and configured to create a defect defined at least in part by portions of both the sacrum and the ilium, the defect having a three dimensional shape defined in part by at least one noncircular cross sectional shape in a plane substantially perpendicular to the longitudinal axis of the tool assembly. After a defect is created, the tool assembly may be retracted and a prosthesis deployed into the defect.

Abstract: Provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Also provided is a method of making antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Further provided is a method of assaying for 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Still further provided is a kit for detecting 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol.

Abstract: A cladding element, for use in a building envelope, comprising a first face, a second face and a plurality of edges. One or more of the plurality of edges includes a mating feature configured to resist moisture passage between cladding elements when the cladding elements are installed on a wall or other structure. The mating features of each cladding element including one or more beveled edges designed to improve mating between the cladding elements and the overall aesthetic appearance of the mating interface between adjacent cladding elements when installed on a wall or other structure.

Abstract: An apparatus is configured for undersea use, such as for penetrating a seabed for forming a borehole therein, including with optional data acquisition and logging capabilities. A first or base module (12) of the apparatus is adapted for engaging the seabed. A first elevator (16) provides longitudinal movement of a second or upper module (14) relative to the base module (12) along a drilling axis. The relative movement of the upper and base modules may be used in the course of independently moving first (18) and second (20) rotary units along the drilling axis to cause a drill rod (R) and a drill casing (C) to penetrate the seabed such that the collapse of the borehole is avoided.

Abstract: Provided are inhibitors of sphingosine kinase Type I that are useful in the treatment of neuropathic pain.

Abstract: The present disclosure provides compounds of formula (I), and preparation method thereof, wherein W is independently selected from the group consisting of H, F, Cl, Br and I; X is independently selected from the group consisting of H, F, Cl, Br, I, CW3 and OR on the basis that at least one X is OR; R is independently selected from the group consisting of C(O)CH2)m(CF2)nY and CW2C(CW2OC(O)(CH2)m(CF2)nY)3; m is an integer from 0 to 2; 15 n is an integer from 2 to 8; Y is C(Z)3; and Z is independently selected from the group consisting of H, F, Cl, Br and I. Such compounds may be utilised as lubricants, for example in heat transfer compositions.

Abstract: A cladding element, for use in a building envelope, comprising a first face, a second face and a plurality of edges. One or more of the plurality of edges includes a mating feature configured to resist moisture passage between cladding elements when the cladding elements are installed on a wall or other structure. The cladding element can include one or more joint features to improve mating between the cladding elements, reduce labor costs, and facilitate moisture drainage from the cladding elements.