Patents by Inventor Robert Etches
Robert Etches has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11542319Abstract: A transgenic chicken comprising an inactivated heavy immunoglobulin gene and/or inactivated light chain immunoglobulin gene is provided, as well as cells and targeting vectors for making the same.Type: GrantFiled: May 15, 2020Date of Patent: January 3, 2023Assignee: CRYSTAL BIOSCIENCE INC.Inventors: Philip A. Leighton, William Don Harriman, Robert Etches
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Publication number: 20220343085Abstract: A method is described that includes receiving a request to translate source content from a first language to a second language. The method includes processing the source content to generate first anonymized content by automatically anonymizing confidential information in the source content. The method also includes providing the first anonymized content to a first service provider to provide anonymization input and processing the first anonymized content with the anonymization input to generate second anonymized content. The method further includes obtaining a machine translation of the second anonymized content from the first language to the second language and providing the machine translation to a second service provider to provide translation input. The method further includes processing the machine translation with the translation input to generate translated content.Type: ApplicationFiled: April 25, 2022Publication date: October 27, 2022Inventors: Robert Etches, Jaromir Dzialo
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Publication number: 20220343087Abstract: Systems, methods, devices, and non-transitory, computer-readable storage media are disclosed for matching a service requester with a service provider via a taxonomy based directed graph. The method includes: receiving a keyword associated with a service; accessing a directed graph including a root node and nodes connected by edges, each node having a title; identifying a second node of the directed graph for each of service providers, each second node having a title matching a skill of a respective service provider; determining a distance between the first node and each second node along the directed graph; and ranking the service providers based at least in part on the distance between the first node and each second node. Systems, methods, devices, and non-transitory, computer-readable storage media are further disclosed for determining and storing a quality score for the revised linguistic content.Type: ApplicationFiled: April 25, 2022Publication date: October 27, 2022Inventors: Robert Etches, Jaromir Dzialo
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Publication number: 20220256820Abstract: This disclosure provides, among other things, strategies for minimizing antibody diversification in a transgenic animal that uses gene conversion for antibody diversification. In some embodiments, the animal may comprise a genome comprising an endogenous immunoglobulin light chain locus comprising: (a) a functional immunoglobulin light chain gene comprising a nucleic acid encoding a light chain variable region; and (b) a plurality of pseudogenes that are operably linked to the functional immunoglobulin light chain gene and that donate, by gene conversion, nucleotide sequence to the nucleic acid encoding a light chain variable region, wherein the pseudogenes are upstream or downstream of the functional immunoglobulin light chain gene and encode the same amino acid sequence as the light chain variable region of the functional immunoglobulin light chain gene of (a). In other embodiments, the locus may have a tandem array of coding sequences for the light chain.Type: ApplicationFiled: April 25, 2022Publication date: August 18, 2022Inventors: Philip A. Leighton, William Don Harriman, Robert Etches
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Patent number: 11337409Abstract: This disclosure provides, among other things, strategies for minimizing antibody diversification in a transgenic animal that uses gene conversion for antibody diversification. In some embodiments, the animal may comprise a genome comprising an endogenous immunoglobulin light chain locus comprising: (a) a functional immunoglobulin light chain gene comprising a nucleic acid encoding a light chain variable region; and (b) a plurality of pseudogenes that are operably linked to the functional immunoglobulin light chain gene and that donate, by gene conversion, nucleotide sequence to the nucleic acid encoding a light chain variable region, wherein the pseudogenes are upstream or downstream of the functional immunoglobulin light chain gene and encode the same amino acid sequence as the light chain variable region of the functional immunoglobulin light chain gene of (a). In other embodiments, the locus may have a tandem array of coding sequences for the light chain.Type: GrantFiled: June 5, 2019Date of Patent: May 24, 2022Assignee: CRYSTAL BIOSCIENCE INC.Inventors: Philip A. Leighton, William Don Harriman, Robert Etches
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Patent number: 11033009Abstract: This disclosure provides, among other things, a transgenic animal and a method of using the same to make antibodies that have a common light chain. In certain embodiments, the transgenic animal may comprising a genome comprising a common light chain transgene, wherein the common light chain transgene comprises a non-immunoglobulin light-chain promoter and a common light-chain coding sequence. In certain embodiments, the common light chain is constitutively expressed.Type: GrantFiled: August 24, 2016Date of Patent: June 15, 2021Assignee: CRYSTAL BIOSCIENCE INC.Inventors: William Don Harriman, Robert Etches, Philip A. Leighton
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Publication number: 20210169055Abstract: This disclosure provides, among other things, strategies for minimizing antibody diversification in a transgenic animal that uses gene conversion for antibody diversification. In some embodiments, the animal may comprise a genome comprising an endogenous immunoglobulin light chain locus comprising: (a) a functional immunoglobulin light chain gene comprising a nucleic acid encoding a light chain variable region; and (b) a plurality of pseudogenes that are operably linked to the functional immunoglobulin light chain gene and that donate, by gene conversion, nucleotide sequence to the nucleic acid encoding a light chain variable region, wherein the pseudogenes are upstream or downstream of the functional immunoglobulin light chain gene and encode the same amino acid sequence as the light chain variable region of the functional immunoglobulin light chain gene of (a). In other embodiments, the locus may have a tandem array of coding sequences for the light chain.Type: ApplicationFiled: June 5, 2019Publication date: June 10, 2021Inventors: Philip A. Leighton, William Don Harriman, Robert Etches
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Publication number: 20210163983Abstract: This disclosure provides, among other things, strategies for minimizing antibody diversification in a transgenic animal that uses gene conversion for antibody diversification. In some embodiments, the animal may comprise a genome comprising an endogenous immunoglobulin light chain locus comprising: (a) a functional immunoglobulin light chain gene comprising a nucleic acid encoding a light chain variable region; and (b) a plurality of pseudogenes that are operably linked to the functional immunoglobulin light chain gene and that donate, by gene conversion, nucleotide sequence to the nucleic acid encoding a light chain variable region, wherein the pseudogenes are upstream or downstream of the functional immunoglobulin light chain gene and encode the same amino acid sequence as the light chain variable region of the functional immunoglobulin light chain gene of (a). In other embodiments, the locus may have a tandem array of coding sequences for the light chain.Type: ApplicationFiled: June 5, 2019Publication date: June 3, 2021Inventors: Philip A. Leighton, William Don Harriman, Robert Etches
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Publication number: 20200308255Abstract: A transgenic chicken comprising an inactivated heavy immunoglobulin gene and/or inactivated light chain immunoglobulin gene is provided, as well as cells and targeting vectors for making the same.Type: ApplicationFiled: May 15, 2020Publication date: October 1, 2020Inventors: Philip A. Leighton, William Don Harriman, Robert Etches
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Patent number: 10689433Abstract: A transgenic chicken comprising an inactivated heavy immunoglobulin gene and/or inactivated light chain immunoglobulin gene is provided, as well as cells and targeting vectors for making the same.Type: GrantFiled: October 2, 2017Date of Patent: June 23, 2020Assignee: CRYSTAL BIOSCIENCE INC.Inventors: Philip A. Leighton, William Don Harriman, Robert Etches
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Patent number: 10687519Abstract: A transgenic animal is provided. In certain embodiments, the transgenic animal comprises a genome comprising: an immunoglobulin light chain locus comprising: a) a functional immunoglobulin light chain gene comprising a transcribed variable region encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of 2 to 5 different amino acids; and ii. a light chain framework; and, operably linked to the functional immunoglobulin light chain gene: b) a plurality of pseudogene light chain variable regions each encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of the same 2 to 5 different amino acids as the CDRs of the functional gene; and ii. a light chain framework that is identical in amino acid sequence to the light chain framework of the transcribed variable region.Type: GrantFiled: May 31, 2019Date of Patent: June 23, 2020Assignee: CRYSTAL BIOSCIENCE INC.Inventors: William Don Harriman, Robert Etches, Philip A. Leighton
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Publication number: 20190320630Abstract: A transgenic animal is provided. In certain embodiments, the transgenic animal comprises a genome comprising: an immunoglobulin light chain locus comprising: a) a functional immunoglobulin light chain gene comprising a transcribed variable region encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of 2 to 5 different amino acids; and ii. a light chain framework; and, operably linked to the functional immunoglobulin light chain gene: b) a plurality of pseudogene light chain variable regions each encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of the same 2 to 5 different amino acids as the CDRs of the functional gene; and ii. a light chain framework that is identical in amino acid sequence to the light chain framework of the transcribed variable region.Type: ApplicationFiled: May 31, 2019Publication date: October 24, 2019Inventors: William Don Harriman, Robert Etches, Philip A. Leighton
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Patent number: 10362770Abstract: A transgenic animal is provided. In certain embodiments, the transgenic animal comprises a genome comprising: an immunoglobulin light chain locus comprising: a) a functional immunoglobulin light chain gene comprising a transcribed variable region encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of 2 to 5 different amino acids; and ii. a light chain framework; and, operably linked to the functional immunoglobulin light chain gene: b) a plurality of pseudogene light chain variable regions each encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of the same 2 to 5 different amino acids as the CDRs of the functional gene; and ii. a light chain framework that is identical in amino acid sequence to the light chain framework of the transcribed variable region.Type: GrantFiled: December 4, 2018Date of Patent: July 30, 2019Assignee: Crystal Bioscience Inc.Inventors: William Don Harriman, Robert Etches, Philip A. Leighton
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Publication number: 20190141967Abstract: A transgenic animal is provided. In certain embodiments, the transgenic animal comprises a genome comprising: an immunoglobulin light chain locus comprising: a) a functional immunoglobulin light chain gene comprising a transcribed variable region encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of 2 to 5 different amino acids; and ii. a light chain framework; and, operably linked to the functional immunoglobulin light chain gene: b) a plurality of pseudogene light chain variable regions each encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of the same 2 to 5 different amino acids as the CDRs of the functional gene; and ii. a light chain framework that is identical in amino acid sequence to the light chain framework of the transcribed variable region.Type: ApplicationFiled: December 4, 2018Publication date: May 16, 2019Inventors: William Don Harriman, Robert Etches, Philip A. Leighton
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Patent number: 10172334Abstract: A transgenic animal is provided. In certain embodiments, the transgenic animal comprises a genome comprising: an immunoglobulin light chain locus comprising: a) a functional immunoglobulin light chain gene comprising a transcribed variable region encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of 2 to 5 different amino acids; and ii. a light chain framework; and, operably linked to the functional immunoglobulin light chain gene: b) a plurality of pseudogene light chain variable regions each encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of the same 2 to 5 different amino acids as the CDRs of the functional gene; and ii. a light chain framework that is identical in amino acid sequence to the light chain framework of the transcribed variable region.Type: GrantFiled: June 1, 2018Date of Patent: January 8, 2019Assignee: Crystal Bioscience Inc.Inventors: William Don Harriman, Robert Etches, Philip A. Leighton
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Publication number: 20180338479Abstract: A transgenic animal is provided. In certain embodiments, the transgenic animal comprises a genome comprising: an immunoglobulin light chain locus comprising: a) a functional immunoglobulin light chain gene comprising a transcribed variable region encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of 2 to 5 different amino acids; and ii. a light chain framework; and, operably linked to the functional immunoglobulin light chain gene: b) a plurality of pseudogene light chain variable regions each encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of the same 2 to 5 different amino acids as the CDRs of the functional gene; and ii. a light chain framework that is identical in amino acid sequence to the light chain framework of the transcribed variable region.Type: ApplicationFiled: June 1, 2018Publication date: November 29, 2018Inventors: William Don Harriman, Robert Etches, Philip A. Leighton
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Publication number: 20180249687Abstract: This disclosure provides, among other things, a transgenic animal and a method of using the same to make antibodies that have a common light chain. In certain embodiments, the transgenic animal may comprising a genome comprising a common light chain transgene, wherein the common light chain transgene comprises a non-immunoglobulin light-chain promoter and a common light-chain coding sequence. In certain embodiments, the common light chain is constitutively expressed.Type: ApplicationFiled: August 24, 2016Publication date: September 6, 2018Inventors: William Don Harriman, Robert Etches, Philip A. Leighton
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Patent number: 10010058Abstract: A transgenic animal is provided. In certain embodiments, the transgenic animal comprises a genome comprising: an immunoglobulin light chain locus comprising: a) a functional immunoglobulin light chain gene comprising a transcribed variable region encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of 2 to 5 different amino acids; and ii. a light chain framework; and, operably linked to the functional immunoglobulin light chain gene: b) a plurality of pseudogene light chain variable regions each encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of the same 2 to 5 different amino acids as the CDRs of the functional gene; and ii. a light chain framework that is identical in amino acid sequence to the light chain framework of the transcribed variable region.Type: GrantFiled: December 13, 2016Date of Patent: July 3, 2018Assignee: Crystal Bioscience Inc.Inventors: William Don Harriman, Robert Etches, Philip A. Leighton
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Publication number: 20180066038Abstract: A transgenic chicken comprising an inactivated heavy immunoglobulin gene and/or inactivated light chain immunoglobulin gene is provided, as well as cells and targeting vectors for making the same.Type: ApplicationFiled: October 2, 2017Publication date: March 8, 2018Inventors: Philip A. Leighton, William Don Harriman, Robert Etches
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Patent number: 9809642Abstract: A transgenic chicken comprising an inactivated heavy immunoglobulin gene and/or inactivated light chain immunoglobulin gene is provided, as well as cells and targeting vectors for making the same.Type: GrantFiled: May 27, 2016Date of Patent: November 7, 2017Assignee: Crystal Bioscience Inc.Inventors: Philip A. Leighton, William Don Harriman, Robert Etches