Abstract: This document provides devices, systems, and methods for detecting pathogens in a biological sample. In some cases, the devices, systems, and methods include a microfluidic device, which includes a biological sample inlet in fluid communication with at least a first microfluidic chamber. The first microfluidic chamber holds a fibrous matrix. The fibrous matrix can carrying anticoagulant and target capture agents within the fibrous matrix. In some cases, the fibrous matrix can be a nonwoven sheet, which can entangle and retain particles bonded to the target capture agents. When in use, a biological sample is introduced into a microfluidic device to flow through the fibrous matrix to mix with the anticoagulant and contact target capture agents. The target capture agents can either remain in the fibrous matrix or flow to a target capture agent chamber.

Abstract: This document provides devices, systems, and methods for delivering fluids. In some cases, the devices, systems, and methods include a reservoir including a sealed flexible material defining a cavity and a housing around the sealed flexible material. The cavity can contain a fluid to be delivered. The sealed flexible material includes at least one breakable seal. The housing includes a rigid side wall supporting said sealed flexible material. In some cases, methods provided herein can deliver fluid by pressing against a top surface of said sealed flexible material. In some cases, systems provided herein can include a controller adapted to receive said cartridge and press a top surface of said sealed flexible material to pressurize said fluid in said cavity to a pressure sufficient to deliver fluid past said breakable seal.

Abstract: Pharmaceutical drugs and formulations suitable for iontophoresis thereof that provide enhanced iontophoretic delivery of an anti-fungal drug to at least one body surface, such as a nail, are described. Also described are pharmaceutical formulations suitable for iontophoresis comprising terbinafine and methods for administering terbinafine to a body surface via iontophoresis. When the drug source is introduced into the nail using a mask, terbinafine concentrations in peripheral areas of nail following iontophoretic treatment are less than drug concentrations directly under the mask. Further, differences in delivered drug concentrations is effectuated by creating drug delivery gradients. Drug can be delivered to dissimilar tissues based on different transfer efficiencies exhibited by the dissimilar tissues, resulting in higher percentage delivery in one tissue vs. another tissue.

Abstract: A transcoder that converts text-based computer software instructions or code intended for use by a presentation engine into a binary code adapted for use by a constrained function presentation engine.

Abstract: A device for electrokinetic delivery of medicament to a treatment site includes a cartridge having an active electrode and a membrane overlying the active electrode and a medicament or a medicament and an electrically conductive carrier therefor, carried by the membrane in electrical contact with the electrode. The electrode opens through a surface of the cartridge remote from the membrane for connection with an electrical connector carried by the device. An locking element releasably couples the cartridge to the housing.

Abstract: The electrokinetic methotrexate delivery system includes at least one applicator having a multiplicity of non-conductive micro-needles carried on a non-conductive surface of the applicator. The opposite surface is formed of electrically conductive material for contact with an active electrode. The applicator includes a matrix containing a medicament, e.g., methotrexate, or a carrier therefor between the opposite surfaces. When the applicator is applied to the individual's skin with the micro-needles penetrating the skin, an electrical current is completed through the power source, the active electrode, methotrexate, or electrically conductive carrier therefor, the targeted treatment site, the individual's body, a ground electrode and the power supply, thereby electokinetically driving the medicament through the non-conductive micro-needles into the targeted treatment site.

Abstract: The electrokinetic medicament delivery system includes at least one applicator having a multiplicity of non-conductive micro-needles carried on a non-conductive surface of the applicator. The opposite surface is formed of electrically conductive material for contact with an active electrode. The applicator includes a matrix containing a medicament or a carrier therefor between the opposite surfaces. When the applicator is applied to the individual's skin with the micro-needles penetrating the skin, an electrical current is completed through the power source, the active electrode, medicament, or electrically conductive carrier therefor, the targeted treatment site, the individual's body, a ground electrode and the power supply, thereby electokinetically driving the medicament through the non-conductive micro-needles into the targeted treatment site.

Abstract: A container assembly (10) comprises a vessel (21) for containing a biological medium, gametes and/or one or more embryo(s). The vessel (21) has a CO2 permeable seal (28) and a closure device (30) for selective access. A buffer chamber (60) for a CO2 enriched atmosphere at least partially surrounds the vessel and is defined by a shell (61). The buffer chamber is in communication with the CO2 permeable wall. Such a container assembly is particularly adapted for IVC in which case the permeable seal (28) prevents ingress of vaginal secretions. The buffer chamber (60) mediates the aqueous pH in the vessel after the container assembly is removed from a CO2 enriched environment.

Abstract: A device for infusion or aspiration that includes a base and at least one needle positioned within the base, where the base includes one or more locators for positioning the infusion device in relation to one or more predetermined anatomical features. A device for infusion or aspiration that comprises a drive assembly and a plurality of needles positioned within the drive assembly. A method for performing infusion or aspiration that includes the steps of establishing the location of the surface of a bone using the tip of a needle and then driving the needle into the bone a predetermined distance from the established location of the surface of the bone.

Abstract: A transcoder that converts text-based computer software instructions or code intended for use by a presentation engine into a binary code adapted for use by a constrained function presentation engine.

Abstract: A system adapted to be disposed between a rigid or semi-rigid device and human skin for reliably attaching the device to the skin for an extended period of time. The system includes a skin-contacting surface for adhering to human skin, and an opposed surface for attachment to a rigid or semi-rigid device. The system is attached along its opposed surface to a portion of the total area of the adjacent surface of the device. When the device is subjected to external stress, the stress is transmitted through the area of attachment and distributed to the unattached area. This minimises stress on the skin and reduces the chance of detachment from the skin.

Abstract: A system adapted to be disposed between a rigid or semi-rigid device and human skin for reliably attaching the device to the skin for an extended period of time. The system includes a skin-contacting surface for adhering to human skin, and an opposed surface for attachment to a rigid or semi-rigid device. The system is attached along its opposed surface to a portion of the total area of the adjacent surface of the device. When the device is subjected to external stress, the stress is transmitted through the area of attachment and distributed to the unattached area. This minimises stress on the skin and reduces the chance of detachment from the skin.

Abstract: An absorbent article for absorption of bodily fluids is provided, including a layer of non-absorbent material defining a tunnel shaped loop and a central portion enclosed by the loop, and an absorbent material retained within the tunnel-shaped loop. The non-absorbent material includes a plurality of apertures through which fluid can flow to reach the absorbent material, and an overwrap material overlies the non-absorbent material to transport fluid over the surface of the non-absorbent material. Preferably the absorbent article is a tampon and the loop is ring shaped.

Abstract: An absorbent article for absorption of bodily fluids is provided, including a layer of non-absorbent material defining a tunnel shaped loop and a central portion enclosed by the loop, and an absorbent material retained within the tunnel-shaped loop. The non-absorbent material includes a plurality of apertures through which fluid can flow to reach the absorbent material, and an overwrap material overlies the non-absorbent material to transport fluid over the surface of the non-absorbent material. Preferably the absorbent article is a tampon and the loop is ring shaped.