Patents by Inventor Robert F. Dannals

Robert F. Dannals has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of the radiolabeled prostate-specific membrane antigen (PSMA) inhibitor [F]DCFPYL
    Patent number: 11851407
    Abstract: Methods, and related compositions, for the improved synthesis of [18F]DCFPyL are disclosed. Also provided are methods, and related compositions, for the use of [18F]DCFPyL so produced.
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: December 26, 2023
    Assignee: THE JOHNS HOPKINS UNIVERSTY
    Inventors: Hayden T. Ravert, Daniel P. Holt, Ying Chen, Ronnie C. Mease, Hong Fan, Martin G. Pomper, Robert F. Dannals
  • SYNTHESIS OF THE RADIOLABELED PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) INHIBITOR [18F]DCFPYL
    Publication number: 20220055991
    Abstract: Methods, and related compositions, for the improved synthesis of [18F]DCFPyL are disclosed. Also provided are methods, and related compositions, for the use of [18F]DCFPyL so produced.
    Type: Application
    Filed: March 9, 2021
    Publication date: February 24, 2022
    Inventors: Hayden T. Ravert, Daniel P. Holt, Ying Chen, Ronnie C. Mease, Hong Fan, Martin G. Pomper, Robert F. Dannals
  • POSITRON EMISSION TOMOGRAPHY (PET) RADIOTRACERS FOR IMAGING MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR (CSF1R) IN NEUROINFLAMMATION
    Publication number: 20210290784
    Abstract: Positron emission tomography (PET) radiotracers for imaging macrophage colony stimulating factor-1 receptors in a subject afflicted with or suspected of being afflicted with a neuroinflammatory or neurodegenerative disease or disorder are disclosed.
    Type: Application
    Filed: June 26, 2019
    Publication date: September 23, 2021
    Inventors: Andrew G. Horti, Ravi Naik, Robert F. Dannals, Martin G. Pomper
  • Synthesis of the radiolabeled prostate-specific membrane antigen (PSMA) inhibitor [F]DCFPyL
    Patent number: 10947197
    Abstract: Methods, and related compositions, for the improved synthesis of [18F]DCFPyL are disclosed. Also provided are methods, and related compositions, for the use of [18F]DCFPyL so produced.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: March 16, 2021
    Assignee: The Johns Hopkins University
    Inventors: Hayden T. Ravert, Daniel P. Holt, Ying Chen, Ronnie C. Mease, Hong Fan, Martin G. Pomper, Robert F. Dannals
  • IMPROVED SYNTHESIS OF THE RADIOLABELED PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) INHIBITOR [18F]DCFPYL
    Publication number: 20190177275
    Abstract: Methods, and related compositions, for the improved synthesis of [18F]DCFPyL are disclosed. Also provided are methods, and related compositions, for the use of [18F]DCFPyL so produced.
    Type: Application
    Filed: June 9, 2017
    Publication date: June 13, 2019
    Inventors: Hayden T. Ravert, Daniel P. Holt, Ying Chen, Ronnie C. Mease, Hong Fan, Martin G. Pomper, Robert F. Dannals
  • Imaging agents and methods of imaging alpha7-nicotinic cholinergic receptor
    Publication number: 20100034741
    Abstract: The present invention relates to radiolabelled compounds particularly 1-azabicyclo[2.2.2]octane compounds (i.e., quinuclidine compounds) which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express the ?7-nicotinic cholinergic receptor. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express ?7-nicotinic cholinergic receptor to which the compounds of the invention have an affinity.
    Type: Application
    Filed: January 26, 2009
    Publication date: February 11, 2010
    Applicants: The Johns Hopkins University
    Inventors: Martin G. Pomper, John L. Musachio, Hong Fan, Robert F. Dannals, Catherine Foss, Eifion Phillips, John Gordon, Dennis McCarthy, Richard Keith, Mark Smith, Richard Heys, Peter N. Dorff
  • Radiotracers for in vivo study of acetylcholinesterase and alzheimer's disease
    Publication number: 20020064500
    Abstract: Methods for detecting acetylcholinesterase in a brain of a patient, comprising administering to the patient a detectable amount of a radiolabeled compound of a class of benzisoxazoles or a pharmaceutically acceptable salt thereof, are disclosed herein. The methods are useful for diagnosing, estimating the severity of, or monitoring the progression of a dementia, such as Alzheimer's disease, in a patient.
    Type: Application
    Filed: April 28, 2000
    Publication date: May 30, 2002
    Inventors: J. James Frost, Robert F. Dannals, John Musachio, Ursula Scheffel, Anabella Villalobos, Badreddine Bencherif
  • Radiolabeled pyridyl-7-azabicyclo[2,2,1]heptanes
    Patent number: 5969144
    Abstract: The present invention is directed to radiolabeled epibatidine analogues, specifically FPH labeled with radioisotopes of fluorine and/or carbon. These radiolabeled epibatidine compounds are used to noninvasively image and quantify nicotinic cholinergic receptors in the living brain for both research studies and the diagnosis of neurodegenerative diseases.
    Type: Grant
    Filed: December 1, 1997
    Date of Patent: October 19, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Edythe D. London, Alane S. Kimes, Andrew Horti, Robert F. Dannals, Michael Kassiou
  • Method for imaging nicotinic acetylcholinergic receptors in the brain using radiolabeled pyridyl-7-azabicyclo ?2.2.1!heptanes
    Patent number: 5726189
    Abstract: The present invention is directed to radiolabeled epibatidine analogues, specifically FPH labeled with radioisotopes of fluorine and/or carbon. These radiolabeled epibatidine compounds are used to noninvasively image and quantify nicotinic cholinergic receptors in the living brain for both research studies and the diagnosis of neurodegenerative diseases.
    Type: Grant
    Filed: May 3, 1996
    Date of Patent: March 10, 1998
    Assignees: The United States of America, represented by The Secretary, Department of Health and Human Services, Johns Hopkins University School of Medicine
    Inventors: Edythe D. London, Alane S. Kimes, Andrew Horti, Robert F. Dannals, Michael Kassiou
  • Brain imaging radiopharmaceuticals
    Patent number: 4638051
    Abstract: The present invention relates to coordination compounds of technetium-99m and chelating agents (ligands) for synthesizing them. The technetium compounds are useful as diagnostic brain imaging radiopharmaceuticals.
    Type: Grant
    Filed: April 17, 1985
    Date of Patent: January 20, 1987
    Assignee: The Johns Hopkins University
    Inventors: Hugh D. Burns, Susan E. Zemyan, Leon A. Epps, Alfred V. Kramer, Robert F. Dannals