Abstract: Systems and apparatuses for soft tissue repair including a device for anchoring sutured tissue to a bone are disclosed. According to one example, the device can include an outer body and an inner member. The outer body can comprise a shell with an outer surface configured to engage the bone of a patient and an inner passage extending longitudinally from a proximal end portion toward a distal end portion. The inner member can be configured to be disposed within the outer body and can be moveable along the inner passage relative to the outer body between a first position and a second position. The inner member can be configured with an eyelet to receive and pass a suture through the member and at least one of the outer body and the inner member can have a first groove extending generally longitudinally along at least a portion thereof. The first groove can be configured to receive the suture therein.

Abstract: A system, devices and methods are provided for facilitating stabilization of periarticular fractures. The system includes a compression plate and one or more of a cerclage cable for encircling the bone and securing the compression plate to the bone, a crimp lug for securing the cable in tension relative to the bone and/or a plate, and a supplemental plate coupled to the compression plate and adapted to receive bicortical or unicortical bone screws to further secure the compression plate relative to the bone. In addition, the system includes a cable tensioner for temporarily retaining the cable in tension and then applying a tension to the cable until a desired compression is effected between a plate and bone and while a cable retaining structure is secured to the cable to retain the applied tension on the cable. Also provided is a jig for use with plates for minimally invasive fracture stabilization.

Abstract: Compositions and methods useful to enhancing, improving, or eliciting anti-tumor immune responses are disclosed. A pterostilbene containing composition is administered to a cancer patient at a sufficient concentration and frequency to induce de-repression of tumor targeting immune responses. The composition enhances antibody dependent cellular toxicity (ADCC) and augments efficacy of antigen specific immunotherapeutics such as trastuzumab and other monoclonal antibody therapies useful for treating cancer.

Abstract: A system, devices and methods are provided for facilitating stabilization of periarticular fractures. The system includes a compression plate and one or more of a cerclage cable for encircling the bone and securing the compression plate to the bone, a crimp lug for securing the cable in tension relative to the bone and/or a plate, and a supplemental plate coupled to the compression plate and adapted to receive bicortical or unicortical bone screws to further secure the compression plate relative to the bone. In addition, the system includes a cable tensioner for temporarily retaining the cable in tension and then applying a tension to the cable until a desired compression is effected between a plate and bone and while a cable retaining structure is secured to the cable to retain the applied tension on the cable. Also provided is a jig for use with plates for minimally invasive fracture stabilization.

Abstract: Compositions and methods useful to enhancing, improving, or eliciting anti-tumor immune responses are disclosed. A pterostilbene containing composition is administered to a cancer patient at a sufficient concentration and frequency to induce de-repression of tumor targeting immune responses. The composition enhances antibody dependent cellular toxicity (ADCC) and augments efficacy of antigen specific immunotherapeutics such as trastuzumab and other monoclonal antibody therapies useful for treating cancer.

Abstract: Systems and apparatuses for soft tissue repair including a device for anchoring sutured tissue to a bone are disclosed. According to one example, the device can include an outer body and an inner member. The outer body can comprise a shell with an outer surface configured to engage the bone of a patient and an inner passage extending longitudinally from a proximal end portion toward a distal end portion. The inner member can be configured to be disposed within the outer body and can be moveable along the inner passage relative to the outer body between a first position and a second position. The inner member can be configured with an eyelet to receive and pass a suture through the member and at least one of the outer body and the inner member can have a first groove extending generally longitudinally along at least a portion thereof.

Abstract: Removable drill guide tips are pre-assembled into threaded holes of a bone plate. The tips may be used with an extension to together function as a conventional drill guide. After drilling, the extension or another tool is used to remove the tips from the plate. According to another use, the tip is used as a guide for a drill bit without any additional extension and then removed with a tool.

Abstract: Removable drill guide tips are pre-assembled into threaded holes of a bone plate. The tips may be used with an extension to together function as a conventional drill guide. After drilling, the extension or another tool is used to remove the tips from the plate. According to another use, the tip is used as a guide for a drill bit without any additional extension and then removed with a tool.

Abstract: Removable drill guide tips are pre-assembled into threaded holes of a bone plate. The tips may be used with an extension to together function as a conventional drill guide. After drilling, the extension or another tool is used to remove the tips from the plate. According to another use, the tip is used as a guide for a drill bit without any additional extension and then removed with a tool.

Abstract: Removable drill guide tips are pre-assembled into threaded holes of a bone plate. The tips may be used with an extension to together function as a conventional drill guide. After drilling, the extension or another tool is used to remove the tips from the plate. According to another use, the tip is used as a guide for a drill bit without any additional extension and then removed with a tool.

Abstract: Removable drill guide tips are pre-assembled into threaded holes of a bone plate. The tips may be used with an extension to together function as a conventional drill guide. After drilling, the extension or another tool is used to remove the tips from the plate. According to another use, the tip is used as a guide for a drill bit without any additional extension and then removed with a tool.

Abstract: A catheter based stent placement system in which the catheter has a clear or translucent transition zone for visual inspection of the stent when placed in the catheter.

Abstract: A catheter based stent placement system in which the catheter has a clear or translucent transition zone for visual inspection of the stent when placed in the catheter.

Abstract: An intravascular catheter comprises a proximal portion and a distal portion. The proximal portion has greater torsional stiffness than the distal portion, while the distal portion has greater dependability than the proximal portion. In accordance with this invention the distal portion carries a helical wire support member embedded therein, the helical support member being essentially free of crossing wires, to provide kink-resistance upon bending to the distal portion.

Abstract: A pseudorandom noise generator (10) is disclosed which includes a maximum length sequence generator (13) for providing a digital signal having a pseudorandom sequence, modulating circuitry (17,20, 25, 27, 33) responsive to the digital signal for providing a constantly changing modulation signal which changes linearly. In one embodiment, the modulation circuitry provides a sequence of linear ramps which remain within predetermined limits, and a voltage controlled oscillator (29) responsive to the modulation signal for providing a pseudorandom noise output VCOUT. The modulating circuitry causes inversion of the slope of the ramps when they reach the predetermined limits.