Abstract: Methods and devices are disclosed for selective delivery of therapeutic substances to specific histologic or microanatomic areas of organs. Introduction of the therapeutic substance into a hollow organ space (such as an hepatobiliary duct or the gallbladder lumen) at a controlled pressure, volume or rate allows the substance to reach a predetermined cellular layer (such as the ephithelium or sub-epithelial space). The volume or flow rate of the substance can be controlled so that the intralumenal pressure reaches a predetermined threshold level beyond which subsequent subepithelial delivery of the substance occurs. Alternatively, a lower pressure is selected that does not exceed the threshold level, so that delivery occurs substantially only to the epithelial layer. Such site specific delivery of therapeutic agents permits localized delivery of substances (for example to the interstitial tissue of an organ) in concentrations that may otherwise produce systemic toxicity.

Abstract: Methods and devices are disclosed for selective delivery of therapeutic substances to specific histologic or microanatomic areas of organs. Introduction of the therapeutic substance into a hollow organ space (such as an hepatobiliary duct or the gallbladder lumen) at a controlled pressure, volume or rate allows the substance to reach a predetermined cellular layer (such as the ephithelium or sub-epithelial space). The volume or flow rate of the substance can be controlled so that the intralumenal pressure reaches a predetermined threshold level beyond which subsequent subepithelial delivery of the substance occurs. Alternatively, a lower pressure is selected that does not exceed the threshold level, so that delivery occurs substantially only to the epithelial layer. Such site specific delivery of therapeutic agents permits localized delivery of substances (for example to the interstitial tissue of an organ) in concentrations that may otherwise produce systemic toxicity.

Abstract: A cage for arboreal animals includes two compartments, each having a hinged, latched, door. The two compartments are separated by a sliding panel to enable maintenance to be performed easily and safely, minimizing unwanted contact between hazardous animals, such as venomous snakes, for example, and the investigators or maintenance personnel. The structure is further ventilated to provide air flow from bottom to top, and could maintain a humidity level in accordance with needs of caged animals. The sides of the cage are transparent to permit simple monitoring of the reptiles as well as to meet the social needs of those animals which need visual contact with other animals in adjacent cages. This cage meets or exceeds all current Federal principles and regulations for animal housing units.

Abstract: Surgical procedures are conducted in a protected environment wherein a laminar flow of micro filtered air is passed from a top to a bottom of an enclosure with transparent panels defining a space for manual access of the surgeon's hands and arms. Air circulation is forced through a high performance HEPA filter between an inlet including the bottom of the enclosure and an outlet at the top, both including panels with an array of apertures for establishing substantially laminar flow. A duct along an endwall of the enclosure carries filtered air to the top. A positive pressure differential is maintained between the inside of the surgical compartment and the outside, to protect the patient operative site from contamination by airborne particles. The enclosure rests on top of a mobile cabinet and has access ports for connection lines and also for bringing the surgical subject into the enclosure. For experimental animals, an access port for cage boxes can be provided.