Patents by Inventor Robert F. Margolskee
Robert F. Margolskee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7960128Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: GrantFiled: March 7, 2008Date of Patent: June 14, 2011Assignee: The Mount Sinai School of MedicineInventors: Robert F. Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian A. Perez
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Patent number: 7960127Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: GrantFiled: February 25, 2008Date of Patent: June 14, 2011Assignee: The Mount Sinai School of MedicineInventors: Robert F. Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian A. Perez
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Publication number: 20080182266Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: ApplicationFiled: March 7, 2008Publication date: July 31, 2008Applicant: Mount Sinai School of Medicine of New York UniversityInventors: Robert F. MARGOLSKEE, Liquan HUANG, Minqing RONG, Marianna MAX, Cristian A. PEREZ
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Publication number: 20080166743Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: ApplicationFiled: February 25, 2008Publication date: July 10, 2008Applicant: MOUNT SINAI SCHOOL OF MEDICINEInventors: Robert F. MARGOLSKEE, Liquan HUANG, Minqing RONG, Marianna MAX, Cristian A. PEREZ
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Patent number: 7364867Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: GrantFiled: April 13, 2001Date of Patent: April 29, 2008Assignee: The Mount Sinai School of MedicineInventors: Robert F. Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian A. Perez
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Patent number: 7341842Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: GrantFiled: April 17, 2006Date of Patent: March 11, 2008Assignee: The Mount Sinai School of MedicineInventors: Robert F. Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian A. Perez
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Patent number: 7314716Abstract: Gustducin is a taste receptor cell heterotrimeric guanine nucleotide binding protein. Disclosed herein is the amino acid sequence of the gamma (?) subunit of gustducin, as well as polynucleotide sequences encoding the ? subunit. Also disclosed are methods of modifying taste involving agents that inhibit or activate the gustducin ? subunit, methods for identifying such taste modifying agents and various taste modifying agents.Type: GrantFiled: June 3, 2002Date of Patent: January 1, 2008Assignee: Mount Sinai School of MedicineInventors: Liquan Huang, Robert F. Margolskee, Marianna Max, Y. Gopi Shanker
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Publication number: 20030166103Abstract: Gustducin is a taste receptor cell heterotrimeric guanine nucleotide binding protein. Disclosed herein is the amino acid sequence of the gamma (&ggr;) subunit of gustducin, as well as polynucleotide sequences encoding the &ggr; subunit. Also disclosed are methods of modifying taste involving agents that inhibit or activate the gustducin &ggr; subunit, methods for identifying such taste modifying agents and various taste modifying agents.Type: ApplicationFiled: June 3, 2002Publication date: September 4, 2003Inventors: Liquan Huang, Robert F. Margolskee, Marianna Max, Y. Gopi Shanker
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Patent number: 6540978Abstract: The present invention relates to methods for identifying inhibitors of the bitter taste response, and by methods of using such inhibitors to either block the perception of bitterness and/or promote the perception of a sweet taste. The inhibitors of the invention may be used as flavor enhancers in foods and pharmaceuticals. The methods of the invention may further be used to characterize the gustatory perception of novel tastants.Type: GrantFiled: December 22, 1999Date of Patent: April 1, 2003Assignee: Mount Sinai School of Medicine of New York UniversityInventors: Robert F. Margolskee, Ding Ming
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Publication number: 20030013119Abstract: A novel taste cell specific guanine nucleotide binding protein, gustducin, is disclosed as well as polynucleotide sequences encoding the &agr; subunit of gustducin. Also disclosed are methods of modifying taste involving agents that inhibit or activate the gustducin &agr; subunit, methods for identifying such taste modifying agents and various taste modifying agents.Type: ApplicationFiled: February 21, 2001Publication date: January 16, 2003Applicant: Linguagen CorporationInventor: Robert F. Margolskee
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Publication number: 20020037515Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: ApplicationFiled: April 13, 2001Publication date: March 28, 2002Applicant: Mount Sinai School of MedicineInventors: Robert F. Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian A. Perez
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Patent number: 6008000Abstract: A novel taste cell specific guanine nucleotide binding protein, gustducin, is disclosed as well as polynucleotide sequences encoding the .alpha. subunit of gustducin. Also disclosed are methods of modifying taste involving agents that inhibit or activate the gustducin .alpha. subunit, methods for identifying such taste modifying agents and various taste modifying agents.Type: GrantFiled: July 28, 1998Date of Patent: December 28, 1999Assignee: Linguagen CorporationInventor: Robert F. Margolskee
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Patent number: 5817759Abstract: A novel taste cell specific guanine nucleotide binding protein, gustducin, is disclosed as well as polynucleotide sequences encoding the .alpha. subunit of gustducin. Also disclosed are methods of modifying taste involving agents that inhibit or activate the gustducin .alpha. subunit, methods for identifying such taste modifying agents and various taste modifying agents.Type: GrantFiled: March 20, 1995Date of Patent: October 6, 1998Assignee: Linguagen CorporationInventor: Robert F. Margolskee
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Patent number: 5688662Abstract: A novel taste cell specific guanine nucleotide binding protein, gustducin, is disclosed as well as polynucleotide sequences encoding the .alpha. subunit of gustducin. Also disclosed are methods of modifying taste involving agents that inhibit or activate the gustducin .alpha. subunit, methods for identifying such taste modifying agents and various taste modifying agents.Type: GrantFiled: April 9, 1992Date of Patent: November 18, 1997Assignee: Linguagen CorporationInventor: Robert F. Margolskee
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Patent number: 5270185Abstract: Asymmetrically tailed plasmid primers are provided, each of which comprises a cut, double-stranded DNA plasmid containing a functional origin of replication, at least one functional selection marker gene, a 3' oligo (dT) tail and a 3' oligo (dC) or oligo (dG) tail which is terminated by a phosphate group. Methods for making and using the primers for the highly efficient production of complex cloning libraries and a kit for carrying out the cloning method of the invention are also provided.Type: GrantFiled: August 12, 1992Date of Patent: December 14, 1993Assignee: Hoffmann-La Roche Inc.Inventor: Robert F. Margolskee
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Patent number: RE40594Abstract: The present invention relates to methods for identifying inhibitors of the bitter taste response, and by methods of using such inhibitors to either block the perception of bitterness and/or promote the perception of a sweet taste. The inhibitors of the invention may be used as flavor enhancers in foods and pharmaceuticals. The methods of the invention may further be used to characterize the gustatory perception of novel tastants.Type: GrantFiled: March 28, 2006Date of Patent: December 2, 2008Assignee: Mount Sinai School of Medicine of New York UniversityInventors: Robert F. Margolskee, Ding Ming