Abstract: Methods and systems for electrocardiogram (ECG) interpretation based on longitudinal medical data are here presented. In one example, a method, comprises, during a development phase of an ECG analysis model, generating a bank of longitudinal electrocardiogram (ECG) features from a plurality of ECGs with known diagnoses; extracting longitudinal criteria from the plurality of ECGs; during a deployment phase of the ECG analysis model, obtaining a plurality of ECGs of a patient, wherein the plurality of ECGs includes a current ECG and one or more historical ECGs; determining, based on the longitudinal criteria, a diagnosis; and transmitting the diagnosis to a user device.

Abstract: Provided herein are compounds that are useful intermediates that may used to synthesize myeloid cell leukemia 1 protein (Mcl-1) inhibitors. Also provided are Mcl-1 inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: An anti-theft barrier for an automatic teller machine is provided. The anti-theft barrier has a first post having a sleeve hinge, a second post having a secure locking housing and a rotating barrier arm. The rotating barrier arm has a first end pivoted from the first post and a second end which locks into the housing of the second post. The housing has an internally hidden and protected lock and bolt and an externally penetrating latch. The anti-theft barrier reduces the chances of attack by deterring unauthorized individuals from being able to unlock the rotating barrier arm to potentially damage or illegally remove the automatic teller machine.

Abstract: A protective cake cover for supporting candles includes a hollow sidewall having an upper end and a lower end, a top cover wall extending across the upper end of the hollow sidewall to define a closed upper end of the protective cake cover, a groove formed in the top cover wall that is configured to support one or more candles that project above the top cover wall, and a recess formed in a central region of the top cover wall and surrounded by the groove, whereby the recess is configured to receive a box that contains candles. The groove has a circular, square, or rectangular shape, and the recess has a square or rectangular shape that is adapted to receive a box of candles that can be stored on the protective cake cover.

Abstract: A resource exploitation management system, method and a computer program product therefor. A description of new geological evidence for a geological resource is received, e.g., as one or more triples describing the evidence. Keywords in the description are matched against keywords in representations in a geological resource database. Geological relations are inferred from the descriptions and matched against predefined geological relations from the geological resource database. Consistent triple matches are merged with the geological resource database. The confidence level for merged matches is updated in the geological resource database.

Abstract: A resource exploitation management system, method and a computer program product therefor. A description of new geological evidence for a geological resource is received, e.g., as one or more triples describing the evidence. Keywords in the description are matched against keywords in representations in a geological resource database. Geological relations are inferred from the descriptions and matched against predefined geological relations from the geological resource database. Consistent triple matches are merged with the geological resource database. The confidence level for merged matches is updated in the geological resource database.

Abstract: A system for processing ECG to detect atrial fibrillation includes three software modules. A beat module is executable on a processor to receive a time series of ECG data, identify heart beats, and determine a beat AFIB value based on a timing of each identified heart beat. The beat AFIB value represents a presence or absence of AFIB based on variability in the timing of each identified heart beat. A segment module is executable to receive the time series of ECG data, divide the time series of ECG data into two or more time segments, and determine a segment AFIB value for each time segment. The segment AFIB value indicates a presence or absence of AFIB in the time segment based on whether any of a set of rhythms are identified. The AFIB detection module is executable to determine an AFIB identification value for each time segment based on the beat AFIB value during that time segment and the segment AFIB value for that time segment.

Abstract: A system for processing ECG to detect atrial fibrillation includes three software modules. A beat module is executable on a processor to receive a time series of ECG data, identify heart beats, and determine a beat AFIB value based on a timing of each identified heart beat. The beat AFIB value represents a presence or absence of AFIB based on variability in the timing of each identified heart beat. A segment module is executable to receive the time series of ECG data, divide the time series of ECG data into two or more time segments, and determine a segment AFIB value for each time segment. The segment AFIB value indicates a presence or absence of AFIB in the time segment based on whether any of a set of rhythms are identified. The AFIB detection module is executable to determine an AFIB identification value for each time segment based on the beat AFIB value during that time segment and the segment AFIB value for that time segment.

Abstract: A technique to enable information sharing among agents within different cache coherency domains. In one embodiment, a graphics device may use one or more caches used by one or more processing cores to store or read information, which may be accessed by one or more processing cores in a manner that does not affect programming and coherency rules pertaining to the graphics device.

Abstract: A method is provided for depositing a whisker resistant tin-based coating layer on a surface of a copper substrate. The method is useful for preparing an article comprising a copper substrate having a surface; and a tin-based coating layer on the surface of the substrate, wherein the tin-based coating layer has a thickness between 0.5 micrometers and 1.5 micrometers and has a resistance to formation of copper-tin intermetallics, wherein said resistance to formation of copper-tin intermetallics is characterized in that, upon exposure of the article to at least seven heating and cooling cycles in which each cycle comprises subjecting the article to a temperature of at least 217° C. followed by cooling to a temperature between about 20° C. and about 28° C., there remains a region of the tin coating layer that is free of copper that is at least 0.25 micrometers thick.

Abstract: The present invention relates to crystalline polymorph forms of (1S)-1-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]ethane-1,2-diol, to pharmaceutical compositions comprising such crystalline polymorph forms, and to processes for preparing them. The invention further relates to methods of treatment of diabetes related disorders comprising administering such solid-state forms or compositions thereof to a subject, and to use of such crystalline polymorph forms in the manufacture of medicaments.

Abstract: One or more apparatus and method for multi-pixel/sample level depth testing in a graphics processor is described. In embodiments, a bounding-box of variable size over which a depth test is to be performed is determined based on the pattern of lit pixels or samples within rasterizer tile. A multi-corner depth test may be performed between a source depth data plane and a destination depth plane within a source depth data bound where destination depth data is continuous within the source data bound. A range-based depth test may be performed in response to the destination data being discontinuous. Source depth data prevailing in the depth test may be stored in a compressed plane equation format in response to the source data being continuous within the source data bound, and may be stored as min/max depth data if discontinuous.

Abstract: A technique to enable information sharing among agents within different cache coherency domains. In one embodiment, a graphics device may use one or more caches used by one or more processing cores to store or read information, which may be accessed by one or more processing cores in a manner that does not affect programming and coherency rules pertaining to the graphics device.

Abstract: A technique to enable information sharing among agents within different cache coherency domains. In one embodiment, a graphics device may use one or more caches used by one or more processing cores to store or read information, which may be accessed by one or more processing cores in a manner that does not affect programming and coherency rules pertaining to the graphics device.

Abstract: A method is provided for depositing a whisker resistant tin-based coating layer on a surface of a copper substrate. The method is useful for preparing an article comprising a copper substrate having a surface; and a tin-based coating layer on the surface of the substrate, wherein the tin-based coating layer has a thickness between 0.5 micrometers and 1.5 micrometers and has a resistance to formation of copper-tin intermetallics, wherein said resistance to formation of copper-tin intermetallics is characterized in that, upon exposure of the article to at least seven heating and cooling cycles in which each cycle comprises subjecting the article to a temperature of at least 217° C. followed by cooling to a temperature between about 20° C. and about 28° C., there remains a region of the tin coating layer that is free of copper that is at least 0.25 micrometers thick.

Abstract: The rapid depth testing for hidden surface removal in graphics processing may be achieved by depth testing representative pixels of a group of pixels. In one embodiment, the worst case pixels of a group of pixels can be identified. The worst case pixels can then be compared to worst case values stored in a hierarchical Z-buffer. Depending on the results, the entire set of pixels of the group may pass or fail the depth test. As a result, in some cases, it is not necessary to depth test every pixel.

Abstract: Embodiments include a fuel rail and method for making the fuel rail. Embodiments of the fuel rail include an elongate lining having a surface defining a lumen, a pressure port having a lumen in fluid communication with the lumen of the elongate lining, and a thermoset composite body surrounding at least a portion of the elongate lining and the pressure port.

Abstract: The present invention provides system, methods, and apparatus for organizing objects obtained from data retrieval. It provides a method to assemble the objects into a set based upon their relevance ranking, associated metadata including categories, and the proximity of these categories in a graph. The method provides for selecting objects according to estimated difficulty, resource type, media format, or other criteria. It also provides for connecting objects into a best path in the graph. It also provides for selecting objects to fit a desired total duration and coverage of relevant categories in the graph. It also provides for organizing the objects into a particular sequence according to the particular metadata. The system, methods, and apparatus are suitable for use in information systems, learning management systems, and other systems employing data retrieval.

Abstract: A vertical-cavity surface-emitting laser (VCSEL) comprising a low-loss thin metal contact and current spreading layer within the optical cavity that provides for improved ohmic contact and lateral current distribution, a substrate including a plano-concave optical cavity, a (Ga,In,Al)N multiple quantum well (MQW) active region contained within the optical cavity that generates light when injected by an electrical current, and an integrated micromirror fabricated onto the substrate that provides for optical mode control of the light generated by the active region. A relatively simple process is used to fabricate the VCSEL.