Abstract: The present disclosure relates generally to eukaryotic initiation factor 2B modulators of formula A, or a pharmaceutically acceptable salt, stereoisomer, or mixture of stereoisomers thereof and methods of making and using thereof.

Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.

Abstract: A biodegradable delivery particle having a benefit agent containing core and a shell.

Abstract: A method of calibrating a transmitter chain in a phased array system in which a lower guard band is assigned to a lower side of an operating carrier of a communication channel and an upper guard band is assigned an upper side of the operating carrier includes injecting a first calibration tone into the transmitter chain and detecting its arrival at the end of the transmitter chain, at which point a first detected calibration signal is generated. The first detected calibration signal and the injected first calibration tone are then compared to produce a first comparison signal. The transmitter chain's phase and/or gain is then adjusted based on this first comparison signal. The first calibration tone located within one of the lower and upper guard bands of the communication channel of the transmitter chain.

Abstract: Populations of benefit agent delivery particles are disclosed, the particles having a core and a polymer wall surrounding the core, the polymer wall comprising multifunctional (meth)acrylate-based polymers, along with processes for making and uses of such compositions, and articles made with such particles. The polymer wall comprises a (meth)acrylate polymer derived, at least in part, from wall monomers and at least one free radical initiator, wherein the wall monomers comprise at least 50%, by weight of the wall monomers, of (meth)acrylate monomers, wherein the at least one free radical initiator is present at a level of from about 15% to about 60%, by weight of the polymer wall, wherein the core comprises a benefit agent, wherein the core and the polymer wall are present in a weight ratio of from about 95:5 to about 99.5:0.5. The compositions deliver core content with a desired delivery profile.

Abstract: The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or prodrug thereof, and methods of making and using thereof.

Abstract: A biosensor is provided including a detection device and a flow cell mounted to the detection device. The detection device has a detector surface with a plurality of reaction sites. The detection device also includes a filter layer. A method is providing including obtaining signal data from an array of light detectors; determining a crosstalk function for each of the light detectors of the array of light detectors; and determining characteristics of analytes of interest based on the signal data using the crosstalk functions.

Abstract: Certain embodiments include an endotracheal (ET) device assembly including an expansion lattice coupled with an expansion and/or contraction actuator. In certain aspects the expansion lattice is position within an open-ended sheath or cover that is position between the trachea and the expansion lattice when deployed.

Abstract: A wiring and connection management system is disclosed. The system comprises a set of power distribution members that are attached to a substrate and are connected together, forming a power grid to distribute power across the substrate. The members include a number of connectors disposed at regular intervals along their lengths. Corresponding sets of cables and connectors on the substrate convey power from the members to areas on the substrate where power is desired. The substrate may be, for example, a shelving unit. The system provides a robust, flexible source of power that is easily installed with minimal training and is also easily maintained.

Abstract: A wiring and connection management system is disclosed. The system comprises a set of power distribution members that are attached to a substrate and are connected together, forming a power grid to distribute power across the substrate. The members include a number of connectors disposed at regular intervals along their lengths. Corresponding sets of cables and connectors on the substrate convey power from the members to areas on the substrate where power is desired. The substrate may be, for example, a shelving unit. The system provides a robust, flexible source of power that is easily installed with minimal training and is also easily maintained.

Abstract: The invention relates to a method (10) in a streaming client (1) for handling video streaming data. The method (10) comprises: receiving (11), decoding (12) and buffering (13) video streaming data comprising frames of image data; displaying (14) the frames of image data on a display (40) of the streaming client (1); receiving (15) an input requesting a pause in the reception of video streaming data; selecting (16), among decoded frames of image data, an optimal frame of image data; continuing (17) displaying frames of image data available in a buffer (45) of the streaming client 1 until the selected optimal frame of image data is encountered; and displaying (18) the selected optimal frame of image data as a still picture on the display (40) of the streaming client (1). The invention also encompasses a streaming client (1), computer program (51) and computer program products (50).

Abstract: The invention relates to a method (10) in a streaming client (1) for handling video streaming data. The method (10) comprises: receiving (11), decoding (12) and buffering (13) video streaming data comprising frames of image data; displaying (14) the frames of image data on a display (40) of the streaming client (1); receiving (15) an input requesting a pause in the reception of video streaming data; selecting (16), among decoded frames of image data, an optimal frame of image data; continuing (17) displaying frames of image data available in a buffer (45) of the streaming client 1 until the selected optimal frame of image data is encountered; and displaying (18) the selected optimal frame of image data as a still picture on the display (40) of the streaming client (1). The invention also encompasses a streaming client (1), computer program (51) and computer program products (50).