Abstract: The present invention relates generally to the use an ERK1/2 inhibitor or a SHP2 inhibitor alone or in combination with a JAK inhibitor for treating cancer, specifically liquid tumors such as a myeloproliferative neoplasm (MPN).

Abstract: The present disclosure relates generally to the use of an ERK1/2 inhibitor in combination with a EGFR inhibitor for treating cancer, specifically solid tumors. The present disclosure also relates to the use of an ERK 1/2 inhibitor in combination with a EGFR inhibitor and a BRAF inhibitor for treating cancer, specifically solid tumors.

Abstract: The present disclosure relates generally to the use an ERK1/2 inhibitor in combination with a SHP2 inhibitor for treating cancer, specifically solid tumors.

Abstract: The present disclosure provides methods of treating cancer with a combination therapy of a SHP2 inhibitor and an inhibitor of CDK4/6.

Abstract: The present disclosure relates generally to the use of an ERK1/2 inhibitor or a SHP2 inhibitor in combination with a FLT3 inhibitor, such as gilteritinib, for treating cancer, specifically acute myeloid leukemia (AML).

Abstract: The present disclosure relates generally to the use of an ERK 1/2 inhibitor in combination with a KRAS G12C inhibitor for treating cancer, specifically solid tumors.

Abstract: An apparatus for providing an infused or brewed beverage comprises a brewing arrangement which is configured to brew a beverage according to a selected one of a plurality of brewing processes, at least one being a hot brewing processes and at least one being a cold brewing process. The apparatus includes a controller configured to receive a user selection indicative of a required beverage, and to control the brewing arrangement in dependence upon the user selection. The apparatus may for example be used to provide either hot brew or cold brew coffee as required, without the need for multiple machines.

Abstract: The present disclosure provides methods of treating cancer with a combination therapies of a SHP2 inhibitor, such as the compound of Formula I, and an FGFR inhibitor, a B-Raf inhibitor, a MEK inhibitor, or a MET inhibitor

Abstract: The present disclosure provides methods of treating cancer with combination therapies of a SHP2 inhibitor and EGFR inhibitor.

Abstract: A foodstuff grinding attachment for connection to a rotary drive outlet of a host device. The attachment includes a main body part having a generally tubular hollowed portion for attachment to the host device. A rotatable scroll-type extruding tool is capable of rotating within a cavity formed in the tubular portion of the main body part and couples with the rotary drive outlet when the main body part is attached to the host device. The main body part includes first and second separable components configured to be secured together for operation of the attachment. The components are separable from one another to provide access to the cavity for cleaning.

Abstract: An electrically powered juicer has a treatment module arranged to subject the expressed juice to a pasteurization or UHT process in order to prevent the rapid deterioration in quality of the expressed juice that otherwise occurs. The lifetime of the juice expressed by the juicer is considerably extended, allowing juice to be prepared in larger volumes than previously and thus negating the requirement for juicing on demand. The treatment module includes serially arranged heating means and cooling means, operative while the expressed juice is traversing a meandering pathway, and a thermostatically controlled element sited and configured to ensure that the heating operation is automatically repeated in the event that juice exiting the heating operation has not reached a predetermined temperature required for the pasteurization or UHT process.

Abstract: An electric toaster with a toasting chamber for a food item, having radiant heaters arranged on opposite sides thereof, and a microwave generator for internally heating the food item. The radiant and the internal heaters can be controlled separately by the user to achieve a required combination of internal and external temperature/texture.

Abstract: A hand saw comprising a handle for actuating the hand saw and a saw blade connected to the handle and provided with a toothed cutting edge, the handle comprising a handle grip clasped by the hand of the user to impart an actuating force to the handle, and the handle grip defining a force entry direction in which the actuating force is introduced into the saw blade, wherein when the hand saw is pushed the force entry direction intersects the cutting edge of the saw blade in the region of a first quarter length of the cutting edge near to the handle or in the region of an imaginary elongation of the cutting edge into the handle.

Abstract: An electrically powered juicer has a treatment module arranged to subject the expressed juice to a pasteurization or UHT process in order to prevent the rapid deterioration in quality of the expressed juice that otherwise occurs. The lifetime of the juice expressed by the juicer is considerably extended, allowing juice to be prepared in larger volumes than previously and thus negating the requirement for juicing on demand. The treatment module includes serially arranged heating means and cooling means, operative while the expressed juice is traversing a meandering pathway, and a thermostatically controlled element sited and configured to ensure that the heating operation is automatically repeated in the event that juice exiting the heating operation has not reached a predetermined temperature required for the pasteurization or UHT process.

Abstract: A guard for a log splitter apparatus is disclosed herein. In various aspects, the guard includes a support member adapted to be secured to a rail of a log splitter apparatus, and a panel hingedly secured to the support member. The panel may be lockably positionable at least between a collapsed position and an extended position. The panel is adapted to capture at least portions of a log, in various aspects. In various aspects, a plurality of support members are located about the panel to secure the panel to the rail of the log splitter apparatus. The support members may be located such that the support members and the panel avoid interference with mechanisms of the log splitter apparatus with the guard secured to the rail. This Abstract is presented to meet requirements of 37 C.F.R. §1.72(b) only. This Abstract is not intended to identify key elements of the apparatus and methods disclosed herein or to delineate the scope thereof.

Abstract: A hand saw comprising a handle for actuating the hand saw and a saw blade connected to the handle and provided with a toothed cutting edge, the handle comprising a handle grip clasped by the hand of the user to impart an actuating force to the handle, and the handle grip defining a force entry direction in which the actuating force is introduced into the saw blade, wherein when the hand saw is pushed the force entry direction intersects the cutting edge of the saw blade in the region of a first quarter length of the cutting edge near to the handle or in the region of an imaginary elongation of the cutting edge into the handle.

Abstract: A saw blade comprising a series of teeth at a longitudinal edge thereof, arranged in alternate directions and formed in a tooth shape as defined by a first flank angle, a second flank angle, and a rake angle, is characterized in that the first flank angle lies between approximately 50.0° to 54.0°, the second flank angle lies between approximately 14.0° to 16.0°, and the rake angle lies between approximately 11.0° to 14.0°.

Abstract: An inflatable structure includes a first inflatable section having an interior open to an airflow from a blower, and a second inflatable section attached to the first inflatable section and having an interior that is substantially closed from the airflow such that if the airflow is stopped the second inflatable section will not deflate as fast as the first inflatable section and will support the first inflatable section.