Abstract: Amino-pyrazinecarboxamide compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of cancer and fibrosis and modulating TGF?R2. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein.

Abstract: Compounds, conjugates and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds may be useful, among other things, in treating of cancer and inhibiting ALKS. Compounds incorporated into a conjugate with an antibody construct are also described herein.

Abstract: Various compositions are disclosed for the treatment of viral infections. The compositions of conjugates comprise antibody constructs attached to myeloid cell agonists via a linker are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating viral infections, such as viral liver diseases.

Abstract: ALK5 inhibitor compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of cancer and fibrosis and modulating ALK5. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein.

Abstract: Various compositions are disclosed. The compositions of conjugates comprising immune-modulatory agents are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating disorders, such as cancer and fibrosis.

Abstract: Various compositions are disclosed. The compositions of conjugates comprising immune-stimulatory compounds are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating disorders, such as cancer.

Abstract: A direct evaporative cooler includes a liquid delivery system and an assembly of two or more plates. At least one plate of the assembly of two or more plates may include a top surface having a wicking material with an exposed surface for receiving a liquid thereon from the liquid delivery system, and one or more masks lining a portion of the exposed surface. The one or more masks may be impermeable to the liquid thereby preventing the liquid from evaporating through the one or more masks, and the one or more masks may be sized and shaped such that a wick rate of the liquid on the exposed surface exceeds an evaporation rate of the liquid.

Abstract: The present application provides a remote control kit for retrofitting controllers for multiple types and brands of vehicle-mounted apparatus (e.g., snow plows and salt spreaders) for wireless control. The kit includes a remote control with a plurality of input elements for controlling the operation of a vehicle-mounted apparatus and a wireless transmitter. The kit further includes an apparatus communicator with a wireless receiver for receiving wireless signals corresponding to different apparatus operations from the wireless transmitter of the remote control. The apparatus communicator connects to the controller of the vehicle-mounted apparatus so that control signals can be transmitted to the controller of the vehicle-mounted apparatus to execute desired apparatus operations.

Abstract: A direct evaporative cooler includes a liquid delivery system and an assembly of two or more plates. At least one plate of the assembly of two or more plates may include a top surface having a wicking material with an exposed surface for receiving a liquid thereon from the liquid delivery system, and one or more masks lining a portion of the exposed surface. The one or more masks may be impermeable to the liquid thereby preventing the liquid from evaporating through the one or more masks, and the one or more masks may be sized and shaped such that a wick rate of the liquid on the exposed surface exceeds an evaporation rate of the liquid.

Abstract: In one embodiment, a plate for an evaporative cooler is disclosed. The plate may comprise a wicking material with an exposed surface and a sealed surface opposite the exposed surface. An impermeable barrier may be coupled to the sealed surface. One or more masks may line a portion of the exposed surface, wherein the masks may comprise an impermeable material. In some embodiments, the mask may be a strip of impermeable material and may be coupled to a flat area of the top surface. In further embodiments, the one or more masks may align with a liquid wick path of the wicking material. In further embodiments, the one or more masks may line the edge of perforations that pass at least partially through the plate.

Abstract: A distributed storage system that includes memory hosts. Each memory host includes non-transitory memory and a network interface controller in communication with the memory and servicing remote direct memory access requests from clients. The memory receives a data transfer rate from each client in communication with the memory host through remote direct memory access. Each memory host also includes a data processor in communication with the memory and the network interface controller. The data processor executes a host process that reads each received client data transfer rate, determines a throttle data transfer rate for each client, and writes each throttle data transfer rate to non-transitory memory accessible by the clients through remote direct memory access.

Abstract: A distributed storage system that includes memory hosts. Each memory host includes non-transitory memory and a network interface controller in communication with the memory and servicing remote direct memory access requests from clients. The memory receives a data transfer rate from each client in communication with the memory host through remote direct memory access. Each memory host also includes a data processor in communication with the memory and the network interface controller. The data processor executes a host process that reads each received client data transfer rate, determines a throttle data transfer rate for each client, and writes each throttle data transfer rate to non-transitory memory accessible by the clients through remote direct memory access.

Abstract: A distributed storage system that includes memory hosts. Each memory host includes non-transitory memory and a network interface controller in communication with the memory and servicing remote direct memory access requests from clients. The memory receives a data transfer rate from each client in communication with the memory host through remote direct memory access. Each memory host also includes a data processor in communication with the memory and the network interface controller. The data processor executes a host process that reads each received client data transfer rate, determines a throttle data transfer rate for each client, and writes each throttle data transfer rate to non-transitory memory accessible by the clients through remote direct memory access.

Abstract: A distributed storage system that includes memory hosts. Each memory host includes non-transitory memory and a network interface controller in communication with the memory and servicing remote direct memory access requests from clients. The memory receives a data transfer rate from each client in communication with the memory host through remote direct memory access. Each memory host also includes a data processor in communication with the memory and the network interface controller. The data processor executes a host process that reads each received client data transfer rate, determines a throttle data transfer rate for each client, and writes each throttle data transfer rate to non-transitory memory accessible by the clients through remote direct memory access.

Abstract: In one embodiment, a plate for an evaporative cooler is disclosed. The plate may comprise a wicking material with an exposed surface and a sealed surface opposite the exposed surface. An impermeable barrier may be coupled to the sealed surface. One or more masks may line a portion of the exposed surface, wherein the masks may comprise an impermeable material. In some embodiments, the mask may be a strip of impermeable material and may be coupled to a flat area of the top surface. In further embodiments, the one or more masks may align with a liquid wick path of the wicking material. In further embodiments, the one or more masks may line the edge of perforations that pass at least partially through the plate.

Abstract: A method is provided for reducing natural organic fouling levels in contaminated ion exchange resins by contacting the resins with an oxidizing agent solution.

Abstract: A method is provided for reducing natural organic fouling levels in contaminated ion exchange resins by contacting the resins with an oxidizing agent solution.

Abstract: Resident activities and/or activity schedules are used to control a home management system. Resident activities and/or activity schedules may be monitored using a calendar application. A common repository may be provided for storing residential information used by multiple applications. Control of the home management system may include the selection of advertising video clips that may replace commercial advertisements in a vide stream. Advertising portions of a video stream may also be replaced with a locally generated video insertion. An architecture and/or system for home management is also provided.

Abstract: A method and apparatus for thermal processing a photosensitive element includes heating a composition layer on a flexible substrate to a melt temperature of an unirradiated area of the composition layer and maintaining the flexible substrate at a temperature below the melt temperature while pressing a heated absorbent layer against the heated composition layer, and repeating these steps for multiple cycles. A further embodiment of the method includes a step of cooling the flexible substrate and layer laminate on each cycle to maintain the flexible substrate at the desired temperature below that of the heated composition layer.

Abstract: A garment in the form of a knee pad or elbow pad protects a wearer during athletic activities. A toughening patch is applied to the outer surface of a nylon shell with the application of heat and pressure. A mixture of Teflon powder and plastisol ink is applied to a release liner and is applied to the nylon shell with the application of heat and pressure. Excess ink is removed from the patch with a blotting paper to impart a relatively low coefficient of friction to the patch.