Patents by Inventor Robert Finley Dubose

Robert Finley Dubose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AMINO-PYRAZINECARBOXAMIDE COMPOUNDS, CONJUGATES, AND USES THEREOF
    Publication number: 20220362396
    Abstract: Amino-pyrazinecarboxamide compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of cancer and fibrosis and modulating TGF?R2. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein.
    Type: Application
    Filed: November 24, 2020
    Publication date: November 17, 2022
    Inventors: Sean Wesley Smith, Craig Alan Coburn, Peter Robert Baum, Robert Finley Dubose
  • ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF
    Publication number: 20210154188
    Abstract: Compounds, conjugates and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds may be useful, among other things, in treating of cancer and inhibiting ALKS. Compounds incorporated into a conjugate with an antibody construct are also described herein.
    Type: Application
    Filed: April 2, 2019
    Publication date: May 27, 2021
    Inventors: Sean Wesley Smith, Craig Alan Coburn, Robert Finley Dubose
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20210154317
    Abstract: Various compositions are disclosed for the treatment of viral infections. The compositions of conjugates comprise antibody constructs attached to myeloid cell agonists via a linker are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating viral infections, such as viral liver diseases.
    Type: Application
    Filed: June 24, 2020
    Publication date: May 27, 2021
    Inventors: Peter Armstrong Thompson, Valerie Odegard, Robert Finley Dubose, Sean Wesley Smith, Craig Alan Coburn
  • ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF
    Publication number: 20210139477
    Abstract: ALK5 inhibitor compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of cancer and fibrosis and modulating ALK5. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein.
    Type: Application
    Filed: July 16, 2020
    Publication date: May 13, 2021
    Inventors: Sean Wesley Smith, Craig Alan Coburn, Peter Robert Baum, Robert Finley Dubose
  • CONJUGATES AND METHODS OF USE THEREOF FOR SELECTIVE DELIVERY OF IMMUNE-MODULATORY AGENTS
    Publication number: 20210115109
    Abstract: Various compositions are disclosed. The compositions of conjugates comprising immune-modulatory agents are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating disorders, such as cancer and fibrosis.
    Type: Application
    Filed: April 23, 2020
    Publication date: April 22, 2021
    Inventors: Peter Armstrong Thompson, Robert Finley Dubose, Peter Robert Baum, Valerie Odegard
  • TUMOR TARGETING CONJUGATES AND METHODS OF USE THEREOF
    Publication number: 20190336615
    Abstract: Various compositions are disclosed. The compositions of conjugates comprising immune-stimulatory compounds are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating disorders, such as cancer.
    Type: Application
    Filed: January 26, 2018
    Publication date: November 7, 2019
    Inventors: Peter Armstrong Thompson, Philip Huat Seng Tan, Peter Robert Baum, Robert Finley Dubose, Craig Alan Coburn, Sean Wesley Smith