Abstract: Disclosed is a closed-loop system that utilizes an implanted responsive tissue stimulator connected electrically to sensing and stimulation electrodes that can detect a precursor of atrial fibrillation or the atrial fibrillation signal itself and then apply electrical stimulation onto some of the patient's tissue such that the atrial fibrillation episode is prevented or terminated. One region for stimulation is at or near the vagal nerves in the neck so as to increase the patient's parasympathetic activity which is known to decrease a tendency for atrial fibrillation. Another region that could be stimulated to decrease the probability of the onset of atrial fibrillation is the region of the left atrium near or in the ostium of the pulmonary veins. Data on the occurrence of atrial fibrillation is recorded in a digital memory so that the patient's doctor can read out these data to optimize the treatment of atrial fibrillation.

Abstract: A system and method for controlling epilepsy and other neurological disorders by providing electrical stimulation to a patient's brain in response to detected neurological conditions. An implantable device includes a stimulation subsystem coupled to a stimulation electrode to provide responsive electrical brain stimulation in response to an event detected via an on-board processor's analysis of data received from a detection subsystem coupled to a detection electrode located in a different portion of the patient's brain.

Abstract: Disclosed are a means and method for rapidly and accurately positioning a toroidal balloon with its distal surface placed tightly against the endocardial surface of the left atrium at a location that is close to the ostium of a pulmonary vein. On the exterior surface of the toroidal balloon can be an electrically conducting wire that is capable of causing rf energy to be placed into the tissue of the left atrium so as to ablate that tissue to alter the conduction of aberrant electrical signals of the heart that are associated with atrial fibrillation. The toroidal balloon is wrapped circumferentially around a tapered balloon that is placed into the pulmonary vein. This system can be applied successively to at least one or as many as all four of the pulmonary veins that enter the left atrium to treat the patient's atrial fibrillation.

Abstract: Disclosed is a system and method for treating migraine headaches employing a readily portable magnetic pulse system that has a head unit connected to a table unit by means of a connecting cable. When a patient senses either the aura of a migraine headache or an ongoing headache, he would turn the table unit on and then press a charge button to charge at least one capacitor in the head unit. When the at least one capacitor is fully charged, the patient would then place the head unit onto his head and then press a button switch that causes the at least one capacitor to discharge into an electromagnetic coil located in the head unit. The high intensity electric current in the electromagnetic coil would then create a high intensity, short duration magnetic pulse onto the patient's brain which can decrease the intensity or duration of the migraine headache.

Abstract: An anti-proliferative drug, such as rapamycin or taxol, is placed onto or within a sheet of material or mesh. The strands onto or into which the drug is placed may be either a permanent implant or it may be biodegradable. Surgical sutures or staples may also be coated and used for connecting human tissues (i.e., for example, an anastomosis).

Abstract: A method for implanting a balloon expandable stent at a site within a passageway of a curved coronary article. The stent includes at least two longitudinally spaced apart circumferential rings. At least one longitudinally extending connector extends between adjacent rings. The connector has at least one turn back portion that can expand or contract in length while being passed through a curved passageway. The stent is disposed on a stent delivery catheter having an inflatable balloon. The stent delivery catheter and the stent is delivered through the passageway to the site of implementation with the connector member expanding or contracting in length to facilitate delivery and placement of the stent. The stent is expanded at the site of implantation by inflating the balloon to force the stent radially outward against the wall of the coronary artery.

Abstract: The present invention is a system that utilizes optimized high pass or band pass filtering to provide accurate detection of changes in the ST segment of an electrogram as detected by an implanted cardiosaver system, which ST segment changes are indicative of coronary ischemia. To accurately detect changes in the ST segment of the electrogram, the cardiosaver system uses either analog or digital high pass filtering having an electrogram voltage reduction of 6 dB at some frequency between 0.05 Hz and 1.0 Hz with less than 6 dB of attenuation at frequencies above 1.0 Hz. and more than 6 dB of attenuation for frequencies below 0.05 Hz. The optimized filter would include attenuation of electric power generation frequencies of either 50 Hz or 60 Hz to reduce electromagnetic interference. The system also includes both implanted and external portions that provide a patient alarm if coronary ischemia is sensed.

Abstract: Disclosed is a “tracker system” that includes implanted electrical leads which are part of an implanted cardiotracker plus external equipment that includes external alarm means and a physician's programmer. The tracker system is designed to monitor the degradation of a patient's cardiovascular condition from one or more causes. These causes include the rejection of a transplanted heart and/or the progression of a stenosis in a coronary artery. As one or more stenoses in a coronary artery become progressively more narrow thereby causing reduced blood flow to the heart muscle coronary circulation, the tracker system can alert the patient by either or both internal and/or external alarm means to take the appropriate medical action. The physician's programmer can be used to display histograms of key heart signal parameters that are indicative of the patient's cardiovascular condition.

Abstract: Disclosed is a system for the treatment of cerebral aneurysms using a stent and a aneurysm pocket fill structure delivery system. One embodiment of the present invention uses a highly radiopaque, drug eluting stent that is deployed with its sidewall over the ostium of the aneurysm pocket. A fill structure delivery catheter is then advanced through the patient's vascular system until the catheter's distal end is situated within the aneurysm pocket. Compressed aneurysm pocket filling structures are then pushed through the fill structure delivery catheter. As the aneurysm pocket filling structures emerge from an opening in the catheter's distal end, they promptly expand so that their minimum dimension is sufficiently large so that they cannot pass through the spaces between the struts of the stent that cover the ostium of the aneurysm pocket.

Abstract: Disclosed is a means and method to decrease mortality and morbidity of patients who regularly undergo either hemodialysis (typically) at a hospital or who undergo peritoneal dialysis at home. The present invention utilizes an implantable system that can detect early signs of a heart attack by noting changes in the electrogram signal from an electrode placed near the apex of the right ventricle of the patient's heart. What is specifically noted from the electrogram for the early detection of a heart attack is a shift in the ST segment compared to a baseline level of the ST segment that was placed in the implanted device's memory at an earlier time. The implanted system is also in contact with an externally located alarm means that also can alert the patient if a heart attack occurs.