Abstract: Described herein are compositions comprising recombinant viral vectors, e.g., recombinant retroviral vectors, for delivering a therapeutic or a vaccine. The recombinant retroviral vectors described herein are modified for safer application of therapeutic or vaccine delivery. Also described herein are methods for using the compositions comprising recombinant viral vectors for delivering a therapeutic or a vaccine.

Abstract: Described herein are compositions for delivering a therapeutic or vaccine. Also described herein are methods for using the compositions described herein for delivering a therapeutic or a vaccine.

Abstract: A bicycle includes a front wheel and a rear wheel and a frameset supported on the front wheel and the rear wheel. The frameset includes a main frame and a front fork rotationally coupled to the main frame. The main frame includes a top tube, a head tube rotationally supporting the front fork, a down tube coupling the head tube to a bottom bracket, a seat tube extending downward from the top tube and including a lower end spaced from the bottom bracket, a seatstay extending rearward from the lower end of the seat tube, and a strut member extending forward from the lower end of the seat tube and connecting the seat tube to the down tube.

Abstract: In an assembly (20) of an elongate inflator (10) which has an outer housing (14) with outflow openings (18) spread along the circumference (U) and defining an outflow area (16) and an outflow direction, and of a clamp-type diffusor (22) enclosing the outflow area (16), the diffusor (22) includes a central receiving opening (24) into which the outer housing (14) protrudes so that the diffusor (22) circumferentially encloses an axial portion of the outer housing (14) which comprises the outflow area (16). At the inner side of the diffusor (22) delimiting the receiving opening (24) at least one bearing surface (34) and at least one gas guiding surface (30) are provided, wherein the bearing surface (34) bears directly against the outer housing (14) of the inflator (10) and the gas guiding surface (30) is radially spaced apart from the outer housing (14) while forming at least one collecting chamber (30) into which gas flowing out of the outflow area (16) is flowing.

Abstract: According to the invention, there is provided a solid pharmaceutical composition formulation for nasal delivery of an opioid antagonist, comprising a pharmacologically-effective amount of an opioid antagonist and a pharmaceutically-acceptable carrier. The compositions are preferably in the form of a powder produced by spray-drying, which are subsequently loaded into single use nasal applicators. Preferred pharmaceutically-acceptable carriers in this regard include disaccharides (e.g. lactose or trehalose) and dextrins (e.g. cyclodextrins or maltodextrins), preferably spray-dried together in combination. Compositions may further comprise an alkyl saccharide, preferably a sucrose ester, such as sucrose monolaurate. The compositions and applicators may be employed in the treatment of opioid overdose in subjects.

Abstract: The present disclosure relates to a pyrotechnic object, in particular an irritation body, irritation projectile or ammunition, comprising an ignition device, comprising a delay chamber extending along a delay path, in which chamber a delay charge is accommodated, and comprising at least one and preferably a plurality of effect chambers in which or in each of which an effect charge to be ignited is accommodated, wherein the delay chamber is transversely connected to a respective effect chamber via a respective over-ignition opening which branches off from the delay chamber and forms an over-ignition path, wherein in the case of a plurality of effect chambers the plurality of over-ignition openings are arranged successively downstream along the delay path in the order of the effect charges to be ignited.

Abstract: An apparatus for determining an interference in a transmission medium during a transmission of a data input signal according to an embodiment has a transform module configured to transform the data input signal from a time domain to a frequency domain comprising a plurality of frequency channels to obtain a frequency-domain data signal comprising a plurality of spectral coefficients, wherein each spectral coefficient is assigned to one of the frequency channels, an analysis module configured to determine the interference by determining one or more spectral interference coefficients, wherein each spectral interference coefficient is assigned to one frequency channel.

Abstract: A method is disclosed for determining and displaying an area comprising a plurality of locations that can be reached by a person or vehicle from a departure node or current position while still reaching a destination node or home location given the initial value at the departure node or current position of a parameter that constrains the distance travelable by the person or vehicle. The method may be implemented on a mobile device such as a portable navigation device and/or on a server or computer, or may be provided as a computer program product.

Abstract: A method for evaluation of a thin-layer chromatography plate after performing a separation process that separates components of a sample on the thin-layer chromatography plate comprises a digitization step, wherein at least two digital images are taken that differ with respect to the wavelength range of illumination of the thin-layer chromatography plate. The method further comprises a position identification step wherein the position of the thin-layer chromatography plate is identified for each of the at least two digital images. Furthermore, the method comprises an evaluation step wherein an image information of the at least two digital images is superimposed for at least all regions with at least one visible spot within at least one of the at least two digital images, so that the superimposition of image information from identical regions of at least two digital images can be used for evaluation of the thin-layer chromatography.

Abstract: A thin-layer chromatography development chamber (1) that can be used for developing thin-layer chromatography plates (21) by introducing a liquid solvent onto a sample arranged on the surface of a thin-layer chromatography plate (21), whereby the solvent and the thin-layer chromatography plate (21) can be inserted into the development chamber (1), comprises a housing (2) with an opening (3). The opening (3) of the development chamber (1) can be closed with a cover (4) that comprises a data input unit (10) for entering or collecting data related to a development process performed within the development chamber (1). The cover (4) further comprises a data communication unit (16) that enables a wireless data transmission of the data related to the development process to a thin-layer chromatography data storage device (24).

Abstract: A method is disclosed for determining and displaying an area comprising a plurality of locations that can be reached by a person or vehicle from a departure node or current position while still reaching a destination node or home location given the initial value at the departure node or current position of a parameter that constrains the distance travelable by the person or vehicle. The method may be implemented on a mobile device such as a portable navigation device and/or on a server or computer, or may be provided as a computer program product.

Abstract: A device and a method for calibrating a light projector (1) with adaptable luminous elements (3) arranged in an image plane (2), comprising a camera (4) and a control unit (5) connected to the light projector (1) and the camera (4), wherein the light projector (1) is configured to project in temporal succession at least two test images (6, 6?) with at least two comparison structures (9, 9?) from the image plane (2) to an arbitrarily extending projection surface (7), the camera (4) is a depth camera configured to record at least two camera images of a recording surface (8) in a manner substantially synchronized temporally with the light projector (1), and to detect the three-dimensional position data of the comparison structures (9, 9?) in the camera images, and the control unit (5) is configured to determine the position and orientation of the light projector (1), and to calculate the translational displacement and rotational twist between camera (4) and projector (1).

Abstract: A bicycle includes a front wheel and a rear wheel and a frameset supported on the front wheel and the rear wheel. The frameset includes a main frame and a front fork rotationally coupled to the main frame. The main frame includes a top tube, a head tube rotationally supporting the front fork, a down tube coupling the head tube to a bottom bracket, a seat tube extending downward from the top tube and including a lower end spaced from the bottom bracket, a seatstay extending rearward from the lower end of the seat tube, and a strut member extending forward from the lower end of the seat tube and connecting the seat tube to the down tube.

Abstract: The present invention relates to cell culture media comprising N-lactoyl derivatives of one or more amino acid. The poor solubility of some amino acids in cell culture media is overcome by substituting them with an N-lactoyl derivative.

Abstract: The present invention relates to cell culture media comprising alpha keto acids. The poor solubility of some amino acids like isoleucine, leucine and valine can be overcome by substituting them with the respective alpha keto acid.

Abstract: The present invention provides compounds (n-3 PUFA derivatives) of formula (I): that modulate conditions associated with cardiac damage, especially cardiac arrhythmias.

Abstract: An apparatus for determining an interference in a transmission medium during a transmission of a data input signal according to an embodiment has a transform module configured to transform the data input signal from a time domain to a frequency domain comprising a plurality of frequency channels to obtain a frequency-domain data signal comprising a plurality of spectral coefficients, wherein each spectral coefficient is assigned to one of the frequency channels, an analysis module configured to determine the interference by determining one or more spectral interference coefficients, wherein each spectral interference coefficient is assigned to one frequency channel.

Abstract: A method for testing a device under test at a specific channel condition is provided. The method comprises the steps of initiating a communication with the device under test and receiving a transmission frame from the device under test with a header portion comprising a specific transmission rate information. It also comprises analyzing the header portion of the transmission frame in order to determine whether the device under test is transmitting with the specific transmission rate information.

Abstract: A dryer appliance that includes a fire extinguishing system is provided. In one aspect, the dryer appliance includes a drum rotatably mounted within a cabinet. The drum defines a chamber for receipt of articles for drying. The dryer appliance includes a water inlet valve in fluid communication with a steam nozzle operable to deliver water into the chamber to form mist or steam. The dryer appliance also includes an extinguisher nozzle in fluid communication with the chamber of the drum and with the water inlet valve. Upon detection of a fire, water is provided to the extinguisher nozzle and the extinguisher nozzle directs a stream of water into the chamber to extinguish the detected fire.