Abstract: The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISATX247, and derivatives thereof. Mixtures of ISATX247 isomers exhibit a combination of enhanced potency and reduced toxicity over the naturally occurring and presently known cyclosporins. ISATX247 isomers and alkylated, arylated, and deuterated derivatives are synthesized by stereoselective pathways where the particular conditions of a reaction determine the degree of siereoselectivity. The ratio of isomers in a mixture may range from about 10 to 90 percent by weight of the (E)-isomer to about 90 to 10 percent by weight of the (Z)-isomer, based on the total weight of the mixture.

Abstract: Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical and isotopic substitution of the cyclosporine A (CsA) molecule by: (1) Chemical substitution and optionally deuterium substitution of amino acid 1; and (2) deuterium substitution at key sites of metabolism of the cyclosporine A molecule such as amino acids 1, 4, 9. Also disclosed are methods of producing the cyclosporine derivatives and method of producing immunosuppression with reduced toxicity with the disclosed cyclosporine derivatives.

Abstract: The present invention provides methods and systems for defining financial transaction components; defining mapping rules for taking individual financial transactions and breaking them down into their components, such as production services, billing services and settlement services. A data processing system in accordance with one embodiment of the present invention, creates a transaction instance corresponding to a financial transaction, creates a production service instance linked to the transaction instance by a first relation instance, and creates a billing service instance linked to the production service instance by a second relation instance. The data processing system, may also create other production service instances linked to the transaction instance using other relation instances, as well as, other billing service instances linked to the production service instances.

Abstract: Use of 13C glucose in an analytical assay to monitor glucose metabolism by measurement of labeled exhaled CO2 is provided. A breath test and kit for performing the breath test are described for the diagnosis of diabetic indications and monitoring of glycemic control. The breath test utilizes the measurement of expired 13C-labeled CO2 following the ingestion of a 13C-enriched glucose source.

Abstract: Method and apparatus for servicing of a bore hole in the earth, comprising a first sub-assembly adapted for the insertion and removal of a continuous length of coiled tubing into and from the bore hole, a second sub-assembly adapted for the vaporization of liquified gas and the pumping of the resulting gas through the coiled tubing into the bore hole and a platform to support both the first and second sub-assemblies thereon.

Abstract: A keg topping device for emplacing an advertising component on top of a keg includes a flat disc surface with an opening therein to fit the device around the mouth of a keg. The opining in the disc forms an inner rim, the perimeter of which, can be fastened to the base around the mouth of the keg by an adhesive. The advertising component is disposed on a surface of the disc member, and in place on the keg, is exposed to view from above. The surface of the disc member, surrounding the opening, is a continuous surface that is free from perforations.

Abstract: A method, apparatus, and computer instructions for improving performance and scalability of common information model object (CIMOM) by using a hardware management console (HMC) repository. The HMC repository includes storage of HMC objects, an HMC object model and a common interface (CIM Wrapper) for accessing to HMC objects. The HMC object model allows the user to store and retrieve the CIM objects and their associations efficiently. A CIM provider may access HMC objects through a common interface (CIM Wrapper), so that different repositories are allowed to be used without significant changes to the underlying server code (CIM provider). A CIM provider may also call the HMC repository directly for more efficient operations because the number of times conversions made between the CIM object and the repository object are greatly decreased.

Abstract: A flameless heating system comprising: at least one engine, each engine including a coolant for removing heat from the engine and each engine producing exhaust; a loading means for loading the engine; a heat exchange system, the heat exchange system comprising: a heat exchange fluid; a pump for circulating the heat exchange fluid; at least one heat exchanger for transferring heat from the at least one engine coolant to the heat exchange fluid; and an exhaust heat exchanger for transferring heat from the exhaust of the at least one engine to the heat exchange fluid; a batch fluid; and a heat exchanger for transferring heat from the heat exchange system to the batch fluid, wherein heat is transferred from the engine to the heat exchange system, and from the heat exchange system to the batch fluid.

Abstract: A commercial riding mower with a chassis built on a relatively rigid frame and having a number of operating systems such as the power plant, motive system, cutter drive system, and fuel storage and delivery system, each of which is accessible through a swing away panel, or hatch, for easy maintenance and repair without compromising safety of the operator or anyone in close proximity to the mower in operation, or impairing the structural integrity of the mower.

Abstract: A method, system, and computer program product are disclosed for managing an application's persistent data across multiple different release versions of the application. A format for a memory area is defined wherein the persistent data will be stored according to a first release version of the application. The format is organized to permit the application running at different release versions to access the memory area. The memory area is accessed using the application that is running at a second release version. The memory area is divided into individually accessible sections. The format includes a template file for each section for each release version.

Abstract: A method, apparatus, and computer instructions for providing addresses to clients. A request is received from a client for an address. A determination is made as to whether authentication information is present in the request. A verification process is performed using the authentication information if the authentication information is presenting the request. A determination is made as to whether the authentication information is authenticated. A privileged address is provided to the client in response to the authentication information being authenticated.

Abstract: An aortic cannula (10) includes an enclosure (12) which may be affixed to the end of the cannula (10) by means of adhesive or may be embedded in the cannula during layered construction thereof. The enclosure (12) expands with flow through the lumen of the cannula (10) such that the flow area through the material of the enclosure is several times the flow cross-sectional area of the cannula lumen.

Abstract: A device and method for improving flow through a native blood vessel valve, such as the aortic valve, are provided. The present invention allows a miniature valve to be implanted into affected leaflets percutaneously, obviating the need for coronary bypass surgery. The method includes the cutting of small holes, on the order of 4 mm, in the leaflets of a targeted valve, thereby allowing blood to flow through the newly formed holes. The holes are used as attachment sites for the miniature valves of the present invention.

Abstract: A device and method for improving flow through a native blood vessel valve, such as the aortic valve, are provided. The present invention allows a miniature valve to be implanted into affected leaflets percutaneously, obviating the need for coronary bypass surgery. The method includes the cutting of small holes, on the order of 4 mm, in the leaflets of a targeted valve, thereby allowing blood to flow through the newly formed holes. The holes are used as attachment sites for the miniature valves of the present invention.

Abstract: A device and method for improving flow through a native blood vessel valve, such as the aortic valve, are provided. The present invention allows a miniature valve to be implanted into affected leaflets percutaneously, obviating the need for coronary bypass surgery. The method includes the cutting of small holes, on the order of 4 mm, in the leaflets of a targeted valve, thereby allowing blood to flow through the newly formed holes. The holes are used as attachment sites for the miniature valves of the present invention.

Abstract: A method and a system for determining taxes attributable to a financial transaction create a tax rate table, link an entity of the financial transaction to the tax rate table through a product rule, and calculate taxes based on the tax rate table according to one component of the financial transaction. The tax rate tables can be linked by a default product rule, which is a defined by a global variable. Alternatively, specific product rules can be used to link specific entities, such as tax jurisdiction records, or legal entity records. In one application, the method and the system calculate revenue tax, cost tax, input tax, and profits for each transaction. The method and the system may further include multi-currency support analysis for a financial transaction so that a financial transaction can be analyzed under a common currency, even though the financial transaction is conducted using one or more currencies in one or more jurisdictions.

Abstract: A commercial riding mower with a chassis built on a relatively rigid frame and having a number of operating systems such as the power plant, motive system, cutter drive system, and fuel storage and delivery system, each of which is accessible through a swing away panel, or hatch, for easy maintenance and repair without compromising safety of the operator or anyone in close proximity to the mower in operation, or impairing the structural integrity of the mower.

Abstract: An optical device, such as an electro-absorption modulator, has a waveguide formed onto a base. Electrodes adjacent the waveguide are used to selectively apply an electric field to the device in order to control the passage of light through the device. To prevent overheating of the device in a region near the point of optical entry, the electrode, which acts as a thermal conduit to dissipate heat from the waveguide is extended over the region. To prevent undesirable electrical contact between the electrode and the region, the normally electrically conducting contact layer between the electrode and the waveguide is removed in that region and replaced by an isolation dielectric.

Abstract: The present invention provides methods and systems for defining financial transaction components; defining mapping rules for taking individual financial transactions and breaking them down into their components, such as production services, billing services and settlement services. A data processing system in accordance with one embodiment of the present invention, creates a transaction instance corresponding to a financial transaction, creates a production service instance linked to the transaction instance by a first relation instance, and creates a billing service instance linked to the production service instance by a second relation instance. The data processing system, may also create other production service instances linked to the transaction instance using other relation instances, as well as, other billing service instances linked to the production service instances.