Patents by Inventor Robert Francis Kester

Robert Francis Kester has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRIDAZINONE GLUCOKINASE ACTIVATORS
    Publication number: 20090264434
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
    Type: Application
    Filed: March 9, 2009
    Publication date: October 22, 2009
    Inventors: Steven Joseph Berthel, Nancy-Ellen Haynes, Robert Francis Kester, Lee Apostle McDermott, Yimin Qian, Ramakanth Sarabu, Nathan Robert Scott, Jefferson Wright Tilley
  • Oxime glucokinase activators
    Publication number: 20080146625
    Abstract: Disclosed herein are pyrazole glucokinase activators of the formula (I): that are useful for the treatment of metabolic diseases and disorders.
    Type: Application
    Filed: December 6, 2007
    Publication date: June 19, 2008
    Inventors: Steven Joseph Berthel, Robert Francis Kester, Douglas Eric Murphy, Thomas Jay Prins, Frank Ruebsam, Chinh Viet Tran, Dionisios Vourloumis
  • Pyrazole glucokinase activators
    Publication number: 20080021032
    Abstract: Disclosed herein are pyrazole glucokinase activators of the formula (I) useful for the treatment of metabolic diseases and disorders, preferably diabetes mellitus.
    Type: Application
    Filed: July 19, 2007
    Publication date: January 24, 2008
    Inventors: Steven Joseph Berthel, Robert Francis Kester, Douglas Eric Murphy, Thomas Jay Prins, Frank Ruebsam, Ramakanth Sarabu, Chinh Viet Tran, Dionisios Vourloumis
  • Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators
    Patent number: 7259166
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: August 21, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Jagdish Kumar Racha, Ramakanth Sarabu, Ka Wang
  • Heteroaromatic glucokinase activators
    Patent number: 7223868
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: April 4, 2005
    Date of Patent: May 29, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Fred Thomas Bizzarro, Wendy Lea Corbett, Joseph Francis Grippo, Nancy-Ellen Haynes, George William Holland, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • 5-substituted-six-membered heteroaromatic glucokinase activators
    Patent number: 7132425
    Abstract: The present invention provides a compound according to formula I where the substituent designations are provided in the specification. Pharmaceutical compositions comprising a compound according to formula I are also provided.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: November 7, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Shaoqing Chen, Wendy Lea Corbett, Kevin Richard Guertin, Nancy-Ellen Haynes, Robert Francis Kester, Francis A. Mennona, Steven Gregory Mischke, Yimin Qian, Ramakanth Sarabu, Nathan Robert Scott, Kshitij Chhabilbhai Thakkar
  • Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators
    Patent number: 7105671
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: April 23, 2003
    Date of Patent: September 12, 2006
    Assignee: Hoffmann-la Roche Inc.
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Jagdish Kumar Racha, Ramakanth Sarabu, Ka Wang
  • Heteroaromatic glucokinase activators
    Patent number: 6951945
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: July 9, 2003
    Date of Patent: October 4, 2005
    Assignee: Hoffman-La Roche Inc.
    Inventors: Fred Thomas Bizzarro, Wendy Lea Corbett, Joseph Francis Grippo, Nancy-Ellen Haynes, George William Holland, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • 5-Substituted-six-membered heteroaromatic glucokinase activators
    Publication number: 20040147748
    Abstract: The present invention provides a compound according to formula I 1
    Type: Application
    Filed: December 10, 2003
    Publication date: July 29, 2004
    Inventors: Shaoqing Chen, Wendy Lea Corbett, Kevin Richard Guertin, Nancy-Ellen Haynes, Robert Francis Kester, Francis A. Mennona, Steven Gregory Mischke, Yimin Qian, Ramakanth Sarabu, Nathan Robert Scott, Kshitij Chhabilbhai Thakkar
  • Heteroaromatic glucokinase activators
    Publication number: 20040014968
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Application
    Filed: July 9, 2003
    Publication date: January 22, 2004
    Inventors: Fred Thomas Bizzarro, Wendy Lea Corbett, Joseph Francis Grippo, Nancy-Ellen Haynes, George William Holland, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators
    Publication number: 20030225283
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Application
    Filed: April 23, 2003
    Publication date: December 4, 2003
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Jagdish Kumar Racha, Ramakanth Sarabu, Ka Wang
  • Heteroaromatic glucokinase activators
    Patent number: 6610846
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: August 26, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Fred Thomas Bizzarro, Wendy Lea Corbett, Joseph Francis Grippo, Nancy-Ellen Haynes, George William Holland, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • &agr;-acyl- and &agr;-heteroatom-substituted benzene acetamide glucokinase activators
    Patent number: 6608218
    Abstract: Substituted benzene acetamide compounds and pharmaceutically acceptable salts thereof are useful as glucokinase activators.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: August 19, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert Francis Kester, Ramakanth Sarabu
  • Fused heteroaromatic glucokinase activators
    Patent number: 6545155
    Abstract: Glucokinase activating amides useful for increasing insulin secretion in the treatment of type II diabetes are disclosed.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: April 8, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • Urea derivatives
    Patent number: 6528543
    Abstract: Glucokinase activating compounds of the formula wherein R1 and R2 are independently hydrogen, halo, amino, nitro, cyano, sulfonamido, lower alkyl, perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, or perfluoro-lower alkyl sulfonyl; R3 is cycloalkyl having from 3 to 7 carbon atoms or lower alkyl having from 2 to 4 carbon atoms; R4 is hydrogen, lower alkyl, lower alkenyl, hydroxy lower alkyl, halo lower alkyl, R5 and R6 are hydrogen or lower alkyl; and n is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof
    Type: Grant
    Filed: March 21, 2000
    Date of Patent: March 4, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Fred Thomas Bizzarro, Wendy Lea Corbett, Antonio Focella, Joseph Francis Grippo, Nancy-Ellen Haynes, George William Holland, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • &agr;-acyl- and &agr;-heteroatom-substituted benzene acetamide glucokinase activators
    Patent number: 6486184
    Abstract: Substituted benzene acetamide compounds which are glucokinase activators and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: November 26, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert Francis Kester, Ramakanth Sarabu
  • Fused heteroaromatic glucokinase activators
    Patent number: 6448399
    Abstract: Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: September 10, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • Fused heteroaromatic glucokinase activators
    Patent number: 6441184
    Abstract: Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: August 27, 2002
    Assignee: Hoffmann-LA Roche Inc.
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • Fused heteroaromatic glucokinase activators
    Patent number: 6433188
    Abstract: Glucokinase activating amides as herein disclosed are useful for increasing insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: August 13, 2002
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • FUSED HETEROAROMATIC GLUCOKINASE ACTIVATORS
    Publication number: 20020107396
    Abstract: Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.
    Type: Application
    Filed: December 4, 2001
    Publication date: August 8, 2002
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu