Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: Microelectronic assemblies, related devices and methods, are disclosed herein. In some embodiments, a microelectronic component may include a substrate having a first face and an opposing second face, wherein the substrate includes a through-substrate via (TSV); a first mold material region at the first face, wherein the first mold material region includes a first through-mold via (TMV) conductively coupled to the TSV; and a second mold material region at the second face, wherein the second mold material region includes a second TMV conductively coupled to the TSV.

Abstract: In an embodiment, an apparatus includes a first baseband section to receive a calibration signal; a first radio frequency (RF) section configured to generate a RF calibration signal based on modulating the calibration signal. The calibration signal comprises an orthogonal code based signal. The apparatus includes a second RF section to receive the RF calibration signal and generate a received calibration signal based on demodulating the RF calibration signal; a calibration section; a first antenna electrically coupled to the first RF section and configured to transmit the RF calibration signal; and a second antenna electrically coupled to the second RF section and configured to receive the RF calibration signal. The calibration section is configured to determine one or more of gain, baseband delay, or RF delay to calibrate the first RF section; and the second antenna is switchable between receiving the RF calibration signal and transmitting an encoded data signal.

Abstract: The present disclosure generally relates to displaying visual effects in image data. In some examples, visual effects include an avatar displayed on a user's face. In some examples, visual effects include stickers applied to image data. In some examples, visual effects include screen effects. In some examples, visual effects are modified based on depth data in the image data.

Abstract: A first aspect of the invention includes a multi-stage gas compressor having a central cam with a plurality of pistons operably connected to and radially extending from the central cam. The cam follower assemblies each include a roller element connected to a roller bracket which rides within and along a guide channel defines by facing grooves formed in housing end plates.

Abstract: The present invention relates to the use, for the preparation of a medicament intended for the treatment or the prevention of pathologies linked to, or caused by mycobacteria, of at least one of the compounds of the following formula (I): in which B represents in particular a nitrogen atom, and R1, R2, R3, R4, R5, R6, R7 and R8 represent in particular a hydrogen atom.

Abstract: A first aspect of the invention includes a multi-stage gas compressor having a central cam with a plurality of pistons operably connected to and radially extending from the central cam. The cam follower assemblies each include a roller element connected to a roller bracket which rides within and along a guide channel defines by facing grooves formed in housing end plates.

Abstract: The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a cell is linked (e.g., covalently crosslinked) to genomic DNA of a cell. The genomic DNA to which the DNA binding protein is linked is removed and combined or contacted with DNA comprising a sequence complementary to genomic DNA of the cell under conditions in which hybridization between the identified genomic DNA and the sequence complementary to genomic DNA occurs. Region(s) of hybridization are region(s) of the genome of the cell to which the protein of binds. A method of identifying a set of genes where cell cycle regulator binding correlates with gene expression and of identifying genomic targets of cell cycle transcription activators in living cells is also encompassed.

Abstract: A method of machining a plurality of intersecting bores in an object, the method comprising steps of machining a first bore, plugging the first bore, machining a second bore so as to intersect the first bore, and unplugging the first bore.

Abstract: A method of machining a plurality of circumferentially spaced bores in an object, each of the bores extending generally tangentially and inwardly and being positioned in the object so as to generally asymmetrically intersect two adjacent bores, comprises the steps of: providing an object; determining a plurality of bore positions generally around a circumference of the object; machining a first bore and performing at least one subsequent machining operation on the first bore to substantially complete the first bore; machining a second bore immediately adjacent to the completed first bore, wherein the second bore is machined so as to intersect the completed first bore, and performing at least one subsequent machining operation on the second bore to substantially complete the second bore; sequentially machining a remaining plurality of bores except a final bore, wherein each said bore is machined so as to intersect an immediately adjacent completed bore; and machining the final bore immediately intermediate the

Abstract: A method of machining a plurality of circumferentially spaced bores in an object, each of the bores extending generally tangentially and inwardly and being positioned in the object so as to generally asymmetrically intersect two adjacent bores, comprises the steps of: providing an object; determining a plurality of bore positions generally around a circumference of the object; machining a first bore and performing at least one subsequent machining operation on the first bore to substantially complete the first bore; machining a second bore immediately adjacent to the completed first bore, wherein the second bore is machined so as to intersect the completed first bore, and performing at least one subsequent machining operation on the second bore to substantially complete the second bore; sequentially machining a remaining plurality of bores except a final bore, wherein each said bore is machined so as to intersect an immediately adjacent completed bore; and machining the final bore immediately intermediate the

Abstract: A method of machining a plurality of circumferentially spaced bores in an object, each of the bores extending generally tangentially and inwardly and being positioned in the object so as to generally asymmetrically intersect two adjacent bores, comprises the steps of: providing an object; determining a plurality of bore positions generally around a circumference of the object; machining a first bore and performing at least one subsequent machining operation on the first bore to substantially complete the first bore; machining a second bore immediately adjacent to the completed first bore, wherein the second bore is machined so as to intersect the completed first bore, and performing at least one subsequent machining operation on the second bore to substantially complete the second bore; sequentially machining a remaining plurality of bores except a final bore, wherein each said bore is machined so as to intersect an immediately adjacent completed bore; and machining the final bore immediately intermediate the

Abstract: The invention concerns a method for cremating human or animal bodies which consists in generating from a wall (10) of the combustion chamber (3), a turbulence in the form of a vertical displacement above the body (2) and in injecting the air required for combustion into this turbulence. Preferably, the turbulence is generated by rotating means (11) directed inside the chamber (3) and equipped with an inlet air duct (17), provided with a closing valve (18) and the air injection is adjusted by actuating the valve.

Abstract: An earpiece which takes the form of a pouch made of a plastics foil which surrounds a less pliant plastics tube in an airtight manner and is filled with a sluggishly moving jelly-like paste.A not readily movable compression ring provided with a funnel shaped portion which is clear of the tube ensures that the pouch is filled in such a way that during use the pouch perfectly engages with the inner wall of the auditory canal.

Abstract: A control device for n recording elements for data which are part of a given plurality of data which can be recorded by each of said elements.This device is made up of n identical control circuits connected respectively to the recording elements, each of said circuits including:-- a first memory for storing, consecutively, the coded data that can be entered in an order determined by the recording element affiliated with the control circuit -- a second memory for storing coded data to be recorded by said element -- a comparator connected to said two memories and controlled by an enabling circuit connected to a time base and to the recording element to cause the timely recording of the data recognized by comparison.