Abstract: A method of aligning a part in digital light processing printer and a part made therefrom. The method includes: establishing an absolute location of a pixel in an x/y plane; deriving a pixel boundary from the absolute location; aligning a three dimensional model with the pixel boundary across a build area of the printer; and printing the part using digital light processing. The part has a surface with a uniform surface morphology.

Abstract: A cartridge assembly for a drug delivery device is described. The cartridge assembly includes (i) a cartridge containing a drug, the cartridge including a dispensing end; (ii) a cartridge holder, the cartridge holder defining an interior cartridge holding section, in which the cartridge is arranged within the cartridge holding section; and (iii) a fixing member. The fixing member includes a fixing surface, in particular a radially oriented surface, which is arranged to abut a cartridge surface of the cartridge, in particular a radially oriented surface. The cartridge surface is a proximal surface which faces away from the dispensing end of the cartridge, and the cartridge surface is arranged between the dispensing end of the cartridge and the end opposite of the dispensing end.

Abstract: The present disclosure is generally directed to an attachment mechanism suitable for attaching a module to an object, e.g. to a portion of a drug delivery device. Further, the disclosure is directed to an electronic system, e.g. an electronic add-on module, which is configured to be, e.g. releasably, attached to a drug delivery device as well as an assembly including the electronic add-on module as well as the drug delivery device. The attachment mechanism may include at least one attachment member with a longitudinal axis, an adhesive distal end surface and an opposite adhesive proximal end surface.

Abstract: Function approximation includes receiving a number value to be input to a function. The number value includes a first and second plurality of bits. A first approximation value of a function is determined using the first plurality of bits as an index to a first lookup table including a plurality of candidate first approximation values. A first correction coefficient is determined using the first plurality of bits as an index to a second lookup table including a plurality of candidate first correction coefficients. A second correction coefficient is determined by using the first plurality of bits as an index to a third lookup table including a plurality of candidate second correction coefficients. A second approximation value of the function is determined based on the first approximation value, the first correction coefficient, and the second plurality of bits.

Abstract: Correction of outliers in a data set includes receiving a first set of inputs of an input dataset requiring positive correction; and receiving a second set of inputs of the input dataset requiring negative correction. Conjunctive clauses with a predetermined number of terms that make all members in the second set of inputs false are identified to form a set of identified conjunctive clauses. Members from the first set of inputs that evaluate to true are collected for each conjunctive clause in the set of identified clauses. The set of identified conjunctive clauses are iterated through until all of the first set of inputs evaluates to true, and the conjunctive clauses are disjuncted to form a disjuncted expression. A correction circuit for the input dataset is generated based on the disjuncted expression.

Abstract: The present disclosure provides compounds of formula (I?) and uses thereof for the treatment of cancer. Also provided are pharmaceutical compositions and kits comprising the same compounds. The present compounds may have improved anti-tumor effect and reduced toxicity and may be useful for targeting mitochondria in cancer cells.

Abstract: Accelerated approximations of functions, including: approximating, by a computing device, a hyperbolic tangent function applied to an input by: where the input is less than zero: performing a first exponentiation comprising raising a first base of two to a first exponent equal to double the input; and subtracting one from a result of the first exponentiation; and where the input is greater than zero, subtracting from one a result of a second exponentiation comprising raising a second base of two to a second exponent equal to a negative of double the input.

Abstract: A drug delivery device for setting and dispensing doses of a liquid drug is described. The device includes a housing and a dose setting and drive mechanism with a dose setting member and a dose setting drum. The dose setting and drive mechanism is configured to perform a dose setting operation for setting a dose to be delivered by the drug delivery device by rotating the dose setting member relative to the housing and a dose delivery operation for delivering the set dose during rotation of the dose setting drum relative to dose setting member the housing. The dose setting drum includes an array of encoder features at its proximal end. The dose setting member has at least one aperture located in a proximal end surface that is coincident with at least a portion of the array of encoder features of the dose setting drum.

Abstract: An assembly for a dual-walled component of a gas turbine engine and methods of forming and repairing a dual-walled component. The assembly includes a cold section part having an outer surface that defines a plurality of impingement apertures, a hot section part including a pre-sintered preform, the hot section part positioned over the outer surface of the cold section part, and a plurality of support structures including the pre-sintered preform, the plurality of support structures positioned between the hot section part and the cold section part, the plurality of support structures separating the hot section part from the cold section part to define at least one cooling channel therebetween.

Abstract: An electronic add-on module configured for releasable attachment to a drug delivery device is described. The electronic add-on module includes at least a body configured to be releasably attached to the device housing, a coupler configured to be releasably attached to the device dial grip, and a dial configured to be axially displaceable with respect to the coupler. The electronic add-on module further includes a tube which is configured to be permanently rotationally constrained to the body and configured to be axially displaceable relative to the body wherein the dial is configured to be rotatable relative to the tube at least in a dialing mode.

Abstract: A cartridge assembly for a drug delivery device is described. The cartridge assembly includes (i) a cartridge containing a drug, the cartridge including a dispensing end; (ii) a cartridge holder, the cartridge holder defining an interior cartridge holding section, in which the cartridge is arranged within the cartridge holding section; and (iii) a fixing member. The fixing member includes a fixing surface arranged to abut a cartridge surface of the cartridge, in particular a radially oriented surface. The cartridge surface is a proximal surface which faces away from the dispensing end of the cartridge, and the cartridge surface is arranged between the dispensing end of the cartridge and the end opposite of the dispensing end. The fixing member includes a securing surface which is arranged to abut a holder surface of the cartridge holder. Further, a drug delivery device and a method for assembling the cartridge assembly are described.

Abstract: Hardware-implemented deep fraction polynomial evaluation includes receiving a floating-point input value to be input to a function with an approximation that includes a polynomial, and converting the floating-point input value to a fixed-point representation including a whole number portion, a leading fraction bits portion, and a remaining fraction bits portion. A first result is computed based on the whole number portion and the leading fraction bits portion using a first computation operation. A second result is computed based on the remaining fraction bits portion using a second computation operation, the second computation operation using a single fixed-point multiply-add instruction defining one or more fused multiply-add operations including a predetermined number of bit shifts with predetermined shift amounts. An output value of the function is computed based on the first result and the second result.

Abstract: A data collection device for attachment to an injection device, such as an injector pen, includes a sensor arrangement to detect movement of a movable component of the injection device relative to the data collection device during delivery of a medicament by the injection device, and a processor arrangement configured to, based on said detected movement, determine a medicament dosage administered by the injection device. The processor arrangement may monitor the time that has elapsed since the medicament dosage was administered, and control a display to show the mediacament dosage and elapsed time to provide a memory aid to the user. In an example embodiment, the sensor arrangement includes an optical encoder and the movable component includes a plurality of light barrier formations. The movable component may be a number sleeve that provides a visual indication of a dose programmed into the injection device.

Abstract: An apparatus for installing cables in overhead transmission and distribution systems and a corresponding method of use are disclosed herein. The apparatus described herein may comprise a dual messenger rolling cable spacer used to install cables in overhead transmission and distribution systems. In various embodiments, the method of using the dual messenger rolling cable spacer may include installing a carrier messenger wire across a span between utility structures. One or more rolling spacers may then be hung from the carrier messenger wire via a roller such that the roller is in contact with the carrier messenger wire. A set of cables and a circuit messenger wire may be affixed to the one or more rolling spacers. The circuit messenger wire may then be pulled across the span causing the one or more rolling spacers to roll along the carrier messenger wire, thereby pulling the set of cables across the span.

Abstract: Disclosed herein are methods and compositions for preparing a surface comprising thermoplastic or thermoset material to receive a polysulfide or polythioether sealant or coating, the method comprising applying to the surface an activating composition consisting of a tetraalkoxide of a Group 4 metal, a complex of an alkoxide of a Group 4 metal, or a combination thereof.

Abstract: A data collection device for attachment to an injection device, such as an injector pen, includes a sensor arrangement to detect movement of a movable component of the injection device relative to the data collection device during delivery of a medicament by the injection device, and a processor arrangement configured to, based on said detected movement, determine a medicament dosage administered by the injection device. The processor arrangement may monitor the time that has elapsed since the medicament dosage was administered, and control a display to show the mediacament dosage and elapsed time to provide a memory aid to the user. In an example embodiment, the sensor arrangement includes an optical encoder and the movable component includes a plurality of light barrier formations. The movable component may be a number sleeve that provides a visual indication of a dose programmed into the injection device.

Abstract: Disclosed herein are methods and compositions for preparing a surface comprising thermoplastic or thermoset material to receive a polysulfide or polythioether sealant or coating, the method comprising applying to the surface an activating composition consisting of a tetraalkoxide of a Group 4 metal, a complex of an alkoxide of a Group 4 metal, or a combination thereof.

Abstract: Presented herein is a system, device and method that involve creating a policy model and policy rule structure for a policy enforcement point to support policies adapt to rapid changing external conditions in addition to traditional policies that are static. The system facilitates the use of attributes that are either or both dynamically (at run-time) created and/or defined as ephemeral. A new policy attribute may be created dynamically (at run-time). The policy attribute may be mapped as being static or ephemeral. The methodology further involves facilitating evaluation of an attribute as an atomic or programmed set of functions.

Abstract: A virtual game world may have game locations based on electronic devices with communications capabilities. In some embodiments electronic devices with communications capabilities are identified to a server, which forms a game location for the identified devices, or at least some of them. The game locations may have non-player controlled game characters as inhabitants of the game locations. One or more characteristics of the inhabitants of a game location may be based on an aspect relating to the electronic device with communication capability with which the game location is associated.

Abstract: A mask forming system for protecting a structure and a method of forming a mask for protecting the structure includes a masking material having a first layer, a second layer, and a third layer sandwiched together. The masking material is unrolled across a platform and a plurality of features are generated in the masking material, wherein the features include printing, kiss cutting, and double-kiss cutting the masking material. Data is printed on the first layer of the masking material. The first layer of the masking material is kiss cut. The second layer of the masking material is double-kiss cut. The third layer remains uncut and unprinted on during the formation of the mask. The masking material remains in the same orientation during printing and kiss cutting of the first layer, and the masking material remains in the same orientation during double-kiss cutting of the second layer.