Abstract: Described are methods for utilizing X-aptamers for detecting human SNAP25 and fragments thereof, and compositions comprising the X-aptamers.

Abstract: A cartridge comprises a chip chamber configured to house a microfluidic chip comprising a plurality of sets of cell channels configured to capture cells from a biological sample. The cartridge also comprises a sample chamber configured to receive the biological sample and be in fluid connection with the plurality of sets of cell channels and a plurality of medium reservoirs. Each medium reservoir of the plurality of medium reservoirs is configured to be in fluid connection with a respective set of cell channels of the plurality of sets of cell channels. The cartridge further comprises culture medium source in fluid connection with the plurality of medium reservoirs and configured to supply a culture medium to the plurality of medium reservoirs.

Abstract: Described are methods for utilizing X-aptamers for detecting human SNAP25 and fragments thereof, and compositions comprising the X-aptamers.

Abstract: Described are cell-based methods for detecting botulinum neurotoxin (BoNT) potency and/or activity in the absence of LD50 assays that rely upon large numbers of laboratory animals.

Abstract: The present disclosure relates generally to peptide reporter constructs of SNAP-25, which are useful in determining the activity of botulinum toxins, and methods of using the same.

Abstract: A gear shifter assembly for a vehicle is described herein. The gear shifter assembly includes a base to be fixed in a vehicle, a shifter yoke mounted to the base by a main pivot shaft, a shift lever mounted to the shifter yoke by a pivotal bearing arranged to allow pivotal movements about a second pivotal axis perpendicular to the first pivotal axis, and an intermediate joint that provides the pivotal bearing of the shift lever. The intermediate joint is attached to the lower end of the shift lever by receiving select pivot pins projecting from the shift lever in recesses of the intermediate joint. The intermediate joint comprises opposite through holes aligned with an aperture in the shift lever for receiving the main pivot shaft. The intermediate joint is made of material having a lower modulus of elasticity than the materials of the shift lever and the shifter yoke.

Abstract: A gear shifter assembly for a vehicle is described herein. The gear shifter assembly includes a base to be fixed in a vehicle, a shifter yoke mounted to the base by a main pivot shaft, a shift lever mounted to the shifter yoke by a pivotal bearing arranged to allow pivotal movements about a second pivotal axis perpendicular to the first pivotal axis, and an intermediate joint that provides the pivotal bearing of the shift lever. The intermediate joint is attached to the lower end of the shift lever by receiving select pivot pins projecting from the shift lever in recesses of the intermediate joint. The intermediate joint comprises opposite through holes aligned with an aperture in the shift lever for receiving the main pivot shaft. The intermediate joint is made of material having a lower modulus of elasticity than the materials of the shift lever and the shifter yoke.

Abstract: A shifter assembly for selecting one of a plurality of gears of a transmission of a vehicle includes a housing having an index track for defining a first mode and a second mode. A shift lever is movably coupled to the housing and interfaces with the index track as the shift lever moves between the modes. A blocker coupled to the housing has a first engagement surface engageable by the shift lever when in the first mode to prevent the shift lever from entering the second mode with the blocker moving in a first direction when the shift lever abuts the first engagement surface. The blocker has a second engagement surface engaged by the shift lever when moving from the first mode to the second mode with the blocker moving in a second direction substantially transverse to the first direction when the shift lever abuts the second engagement surface.

Abstract: A shifter assembly for selecting one of a plurality of gears of a transmission of a vehicle includes a housing having an index track for defining a first mode and a second mode. A shift lever is movably coupled to the housing and interfaces with the index track as the shift lever moves between the modes. A blocker coupled to the housing has a first engagement surface engageable by the shift lever when in the first mode to prevent the shift lever from entering the second mode with the blocker moving in a first direction when the shift lever abuts the first engagement surface. The blocker has a second engagement surface engaged by the shift lever when moving from the first mode to the second mode with the blocker moving in a second direction substantially transverse to the first direction when the shift lever abuts the second engagement surface.

Abstract: A removable core lock and key device comprises a cylinder housing (10) and a cylinder core (20), which is accommodated in a circular opening in the cylinder housing. A plurality of pin tumblers (22) are movable under influence from code surfaces of a key, wherein at least part of the pin tumblers are provided in a recess (20b) in the mantle surface of the cylinder core. A cam adapter (40) is rotatably provided in the opening in the cylinder housing. The cam adapter comprises an engagement portion (40c) which engages the recess (20b) in the mantle surface of the cylinder core when the cylinder core is in an operative position, wherein at least one of the pin tumblers is movable between a blocking position, in which the engagement portion of the cam adapter cooperates with the at least one pin tumbler to prevent mutual axial movement of the cam adapter and the cylinder core, and a release position, in which mutual axial movement between the cam adapter and the cylinder core is allowed.

Abstract: A removable core lock and key device comprises a cylinder housing (10) and a cylinder core (20), which is accommodated in a circular opening in the cylinder housing. A plurality of pin tumblers (22) are movable under influence from code surfaces of a key, wherein at least part of the pin tumblers are provided in a recess (20b) in the mantle surface of the cylinder core. A cam adapter (40) is rotatably provided in the opening in the cylinder housing. The cam adapter comprises an engagement portion (40c) which engages the recess (20b) in the mantle surface of the cylinder core when the cylinder core is in an operative position, wherein at least one of the pin tumblers is movable between a blocking position, in which the engagement portion of the cam adapter cooperates with the at least one pin tumbler to prevent mutual axial movement of the cam adapter and the cylinder core, and a release position, in which mutual axial movement between the cam adapter and the cylinder core is allowed.

Abstract: A key safekeeping device for fitting into a hole in a door, wall or corresponding structure includes a first tubular element (10) that carries a first collar (12) on an outer end thereof. A lock cylinder (14) is detachably fitted to the first tubular element. A second tubular element (20) that carries a second collar (22) is intended for lockable engagement with the first tubular element. At least one of the collars is comprised of a separate ring-shaped part (22) that includes an internal aperture for receiving a blocking means (24) in the form of a bent/curved element that is intended to be fitted into a peripheral groove (20c) in the barrel surface of the second tubular element. The blocking element, which lies hidden in the aperture of the ring-shaped part, cannot therefore be removed when the key safekeeping device is fitted and the lock cylinder is mounted in place.

Abstract: A key safekeeping device for fitting into a hole in a door, wall or corresponding structure includes a first tubular element (10) that carries a first collar (12) on an outer end thereof. A lock cylinder (14) is detachably fitted to the first tubular element. A second tubular element (20) that carries a second collar (22) is intended for lockable engagement with the first tubular element. At least one of the collars is comprised of a separate ring-shaped part (22) that includes an internal aperture for receiving a blocking means (24) in the form of a bent/curved element that is intended to be fitted into a peripheral groove (20c) in the barrel surface of the second tubular element. The blocking element, which lies hidden in the aperture of the ring-shaped part, cannot therefore be removed when the key safekeeping device is fitted and the lock cylinder is mounted in place.