Abstract: Disclosed herein is a formation evaluation method including estimating a total porosity of an earth formation as a function of bulk density and total nuclear magnetic resonance (NMR) porosity of the earth formation. The total porosity of the earth formation as estimated underrepresents bitumen content. A gas filled porosity of the earth formation is estimated as a function of the bulk density and the total NMR porosity. A kerogen volume of the earth formation is estimated as a function of the gas filled porosity and a total organic carbon content of the earth formation. A bitumen filled total porosity is determined as a function of the estimated kerogen volume and the estimated total porosity of the earth formation. A corrected kerogen volume of the earth formation is determined as a function of the estimated kerogen volume and the estimated total porosity of the earth formation.

Abstract: An in vitro methods of characterizing biliary excretion of a chemical entity using a single hepatocyte culture. Comprising providing cell culture comprising hepatocytes forming at least one bile canaliculus; contacting the cell culture with a first chemical entity for a time sufficient to allow uptake of the chemical entity by hepatocytes in the culture; disrupting the at least one bile canaliculus without lysing the hepatocytes and detecting the amount (if any) of the first chemical entity and/or a metabolite thereof released by the at least one bile canaliculus; and lysing the hepatocytes and detecting the amount of the first chemical entity and/or a metabolite thereof released by the hepatocytes.

Abstract: Disclosed herein is a formation evaluation method including estimating a total porosity of an earth formation as a function of bulk density and total nuclear magnetic resonance (NMR) porosity of the earth formation. The total porosity of the earth formation as estimated underrepresents bitumen content. A gas filled porosity of the earth formation is estimated as a function of the bulk density and the total NMR porosity. A kerogen volume of the earth formation is estimated as a function of the gas filled porosity and a total organic carbon content of the earth formation. A bitumen filled total porosity is determined as a function of the estimated kerogen volume and the estimated total porosity of the earth formation. A corrected kerogen volume of the earth formation is determined as a function of the estimated kerogen volume and the estimated total porosity of the earth formation.

Abstract: The Larmor frequency for an in situ nuclear magnetic resonance (NMR) tool is determined and used to acquire NMR data. An NMR tool is provided and placed in situ, for example, in a wellbore. An initial estimate of the Larmor frequency for the in situ NMR tool is made and NMR data are acquired using the in situ NMR tool. A spectral analysis is performed on the NMR data, or optionally, the NMR data are digitized and a discrete Fourier transform (DFT) is performed on the digitized NMR data. The modal frequency of the spectral analysis or DFT is determined, and the Larmor frequency for the in situ NMR tool is determined using the modal frequency. The NMR tool is modified to transmit at the determined Larmor frequency and then used to acquire further NMR data.

Abstract: Methods of characterizing the time-based hepatotoxicity of a test compound are provided. In some embodiments the provided methods allow prediction of the hepatotoxic potential of a test compound in a way that is improved relative to that achievable with prior art methods. In some embodiments the methods may be used to quantify the relationship between measurements or estimates of toxicity made at different, successive points in time, to provide highly meaningful tool to assess the likely in vivo hepatotoxicity of test compounds in vivo.

Abstract: An apparatus for NMR properties of subsurface formations includes a magnet, a transmitter antenna and at least one of a receiver section of the transmit antenna or a separate receiver antenna having a length along the longitudinal dimension of the apparatus which is shorter than a length of the transmitter antenna along the longitudinal dimension. The apparatus includes circuitry for applying radio frequency current pulses to the entire transmitter antenna and for receiving signals by the at least one of the receiver section of the transmitter antenna and the separate receiver antenna.

Abstract: A method for predicting at least one property of a geological formation may include generating mapping function values relating a plurality of reference elemental compositions to corresponding reference properties thereof based upon at least one non-linear mapping function. The method may further include determining a sample elemental composition of at least one sample associated with the geological formation and performing, using a processor, an interpolation to map the sample elemental composition to at least one sample property based upon the mapping function values and the at least one non-linear function.

Abstract: Devices and methods are provided for detecting an immune reaction to a test agent using an immune modeling system comprising a barrier component configured to culture a biological barrier, an immune component configured to culture immune cells, and one or more inter-component microfluidic connections between the barrier component and the immune component. The system provides for culturing a biological barrier in the barrier component of the system, culturing immune cells in the immune component of the system, applying the test agent to the biological barrier, and monitoring the immune cells to detect an immune reaction to the test agent.

Abstract: A nuclear magnetic resonance (NMR) measurement system for high pressure and temperature measurements on fluids is disclosed. The system has a sensor assembly that includes a sample holder having a body formed from a non-magnetic metal and defining an interior cavity for receiving a fluid sample, a frame member disposed in the interior cavity of the sample holder, an antenna coil disposed in the interior cavity about the frame member, an inlet that allows the fluid sample to enter the interior cavity, an outlet that allows for the fluid sample to be flushed from the interior cavity, and a magnet assembly having a central bore in which the sample holder is disposed. Adjacent to the sample holder are pulsed field gradient coils for performing diffusion measurements. The system further includes pulse sequencer circuitry that supplies signals to the antenna coil.

Abstract: Compositions and methods described herein provide a cell culture system in which cells are in high metabolic states from the onset of the culture. Combinations of various cell culture components disclosed and employed herein allow cells to be in high metabolic states useful for drug testing immediately after the start of cell culture.

Abstract: An in vitro methods of characterizing biliary excretion of a chemical entity using a single hepatocyte culture. Comprising providing cell culture comprising hepatocytes forming at least one bile canaliculus; contacting the cell culture with a first chemical entity for a time sufficient to allow uptake of the chemical entity by hepatocytes in the culture; disrupting the at least one bile canaliculus without lysing the hepatocytes and detecting the amount (if any) of the first chemical entity and/or a metabolite thereof released by the at least one bile canaliculus; and lysing the hepatocytes and detecting the amount of the first chemical entity and/or a metabolite thereof released by the hepatocytes.

Abstract: Compositions and methods described herein provide a cell culture system in which cells are in high metabolic states from the onset of the culture. Combinations of various cell culture components disclosed and employed herein allow cells to be in high metabolic states useful for drug testing immediately after the start of cell culture.

Abstract: A nuclear magnetic resonance (NMR) measurement system for high pressure and temperature measurements on fluids is disclosed. The system has a sensor assembly that includes a sample holder having a body formed from a non-magnetic metal and defining an interior cavity for receiving a fluid sample, a frame member disposed in the interior cavity of the sample holder, an antenna coil disposed in the interior cavity about the frame member, an inlet that allows the fluid sample to enter the interior cavity, an outlet that allows for the fluid sample to be flushed from the interior cavity, and a magnet assembly having a central bore in which the sample holder is disposed. Adjacent to the sample holder are pulsed field gradient coils for performing diffusion measurements. The system further includes pulse sequencer circuitry that supplies signals to the antenna coil.

Abstract: A method for predicting at least one property of a geological formation may include generating mapping function values relating a plurality of reference elemental compositions to corresponding reference properties thereof based upon at least one non-linear mapping function. The method may further include determining a sample elemental composition of at least one sample associated with the geological formation and performing, using a processor, an interpolation to map the sample elemental composition to at least one sample property based upon the mapping function values and the at least one non-linear function.

Abstract: The Larmor frequency for an in situ nuclear magnetic resonance (NMR) tool is determined and used to acquire NMR data. An NMR tool is provided and placed in situ, for example, in a wellbore. An initial estimate of the Larmor frequency for the in situ NMR tool is made and NMR data are acquired using the in situ NMR tool. A spectral analysis is performed on the NMR data, or optionally, the NMR data are digitized and a discrete Fourier transform (DFT) is performed on the digitized NMR data. The modal frequency of the spectral analysis or DFT is determined, and the Larmor frequency for the in situ NMR tool is determined using the modal frequency. The NMR tool is modified to transmit at the determined Larmor frequency and then used to acquire further NMR data.

Abstract: The Larmor frequency for an in situ nuclear magnetic resonance (NMR) tool is determined and used to acquire NMR data. An NMR tool is provided and placed in situ, for example, in a wellbore. An initial estimate of the Larmor frequency for the in situ NMR tool is made and NMR data are acquired using the in situ NMR tool. A spectral analysis is performed on the NMR data, or optionally, the NMR data are digitized and a discrete Fourier transform (DFT) is performed on the digitized NMR data. The modal frequency of the spectral analysis or DFT is determined, and the Larmor frequency for the in situ NMR tool is determined using the modal frequency. The NMR tool is modified to transmit at the determined Larmor frequency and then used to acquire further NMR data.

Abstract: Disclosed is a model-independent method for accurate prediction of formation and borehole properties from neutron capture cross section measurements. A mapping function is constructed which maps the input measurements to the properties of interest. The mapping function is a linear combination of Gauss radial basis functions. The expansion coefficients and widths of the Gaussian functions are determined uniquely using a database populated with representative samples. For a sample not included in the original database, the desired properties can be estimated from the mapping function using the measurements made on the unknown sample.

Abstract: Methods and systems are provided for obtaining both magnetic and apparent resistivity ultra-deep reading electromagnetic measurements at the same time and/or by a single tool. The system can include a magnetometer, a current source electrode, a pair of voltage measuring electrodes, and a current return electrode. Using such a system can enable a lowering a tool into a relief well and obtaining both magnetic and apparent resistivity ultra-deep reading electromagnetic measurements in a single trip in order to provide a more accurate and faster determination of the distance and direction to a cased blown out well in order to shorten the time required to intersect and kill the blown out well.

Abstract: The present invention relates to making one or more measurements in a virgin formation using a downhole tool that includes a miniature logging tool. The downhole tool is disposed in a wellbore penetrating the formation, adjacent to the formation, and a sidetrack borehole is made into the formation. All or a portion of the miniature logging tool is deployed into the sidetrack borehole and measurements are made in the virgin formation using the miniature logging tool. The downhole tool may include a drilling/coring module, a pump module, and packers. The drilling/coring module is used to make the sidetrack borehole, and the packers and pump module can be used to create an underbalanced drilling condition in an isolated section of the wellbore.

Abstract: A downhole micro MR analyzer for use in a wellbore, having a micro sample tube, a micro RF coil in close proximity to the micro sample tube, and one or more magnets disposed about the micro sample tube is disclosed. The micro MR analyzer can be used for nuclear magnetic resonance or electron spin resonance experiments to ascertain formation properties and chemical compositions.