Abstract: Methods and assays for performing a lateral flow test are disclosed. A sample is applied to a receiving portion of a lateral flow device such that the sample flows to at least a first test zone and a second test zone. First and second signals levels at the first and second test zones over an assay period are monitored. If a first analyte of interest is present in the sample, the first analyte is labelled and the presence of labelled first analyte in the sample causes one of the first and second signals levels to increase during the assay period. A change between the first and second signal levels over a period of time during the assay period is monitored. The sample can be incubated prior to application to the receiving portion to provide homogeneity to labelling and therefore a substantially linear increase of the signal level at one of the test zones and a substantially constant signal level at the other one of the test zones.

Abstract: In some embodiments a diagnostic system is disclosed including a test device for performing diagnostic analysis of a biological sample from a human or animal body, the test device having an assay and a reader to analyse the sample and determine one or more biological conditions and to generate a result data signal containing information on the determination of the one or more biological conditions. The system also comprises a base device to releasably receive the test device, receive the result data signal from the test device, and display results of testing based on the received result data signal. In some embodiments a fluid receptacle is configured to be releasably retained to a test device, the test device comprising a housing, the housing having an engagement element for releasably retaining the fluid receptacle on an outer surface of the housing.

Abstract: The present disclosure relates generally to nanoparticle aggregates and to methods for preparing nanoparticle aggregates in a controlled manner The nanoparticle aggregates are useful in a variety of applications including detection and quantitation assays. In one illustrative example, the nanoparticle aggregates are particularly useful in medical diagnostic applications.

Abstract: A sampling device for collecting and dispensing a sample is disclosed, the sampling device including a sample collector having an absorbent portion configured to collect a sample and a receiving section configured to receive the sample collector after the collection of the sample. In one embodiment, the receiving section includes a dropper, the sample collector configured to be secured to the dropper, the dropper defining an internal chamber in which the absorbent portion of the sample collector is received when the sample collector is secured to the dropper; and a base releasably engaged with the dropper and at least partially housing the dropper, wherein the dropper is configured to be released from the base to allow dispensing of the sample from the dropper. In one embodiment, the absorbent portion interferes with a surface of an internal chamber of the receiving section. In one embodiment, a length adapter for the sample collector is employed and, in another embodiment, a desiccant housing is employed.

Abstract: A data marketplace infrastructure provides a crowd sourcing solution to development, discovery and publication of decision applications. Applications can be submitted from a user to a data warehouse in association with a data feed. One or more discovery properties are determined with regard to each application. The applications are made available to other client systems in association with the data feed. A relevant data feed and a relevant application can be identified based on satisfaction of a discovery request by the one or more determined discovery properties of the application. The application can be selected and downloaded to the user for evaluation and customization. The customized application can then be submitted to the data warehouse for publication with the other applications associated with the data feed.

Abstract: A data processing method comprising obtaining a plurality of computer network security threat feeds from two or more computer threat detection systems; based upon computer network attack information in the computer network security threat feeds, determining a threat score that represents a severity of an actual or suspected attack on a particular host in a computer network; obtaining an asset value for the particular host that indicates a worth of the particular host, and updating the threat score based upon the asset value; mapping the updated threat score to one of a plurality of remediation actions, wherein a first remediation action is mapped when the updated threat score is low and a second, different remediation action is mapped when the updated threat score is high; based upon the updated threat score and the mapping, selecting and automatically performing one of the plurality of remediation actions on the particular host; wherein the method is performed by one or more special-purpose computing devices

Abstract: Network utilization of an arbitrary application is controlled by tracking network usage statistics of virtual machines (VMs), including at least VMs hosting parts of the application. For network utilization control, VMs serve as network proxies for elements of the application. A specification for a network requirement of the application is evaluated against the network usage statistics. When a network capacity requirement to/from/through an element of the application is not satisfied, one or more VMs are adapted to satisfy the requirement. For example, a VM may be migrated from a host or network location that has excess network bandwidth. Or, for example, network bandwidth availability for an under-requirement VM may be increased and bandwidth availability for a VM at an appropriate host or network location may be decreased. Thus, application-level communication path requirements may be satisfied using VM adaptations.

Abstract: A tip for twist drill, comprising a super-hard structure joined to a substrate at an interface boundary coterminous with an end of the substrate, the super-hard structure comprising sintered polycrystalline material comprising super-hard grains, the super-hard structure defining a super-hard end surface opposite the interface boundary and a plurality of cutting edges configured for boring into a body in use; the super-hard end surface including a center point or chisel edge, and comprising a plurality of surface regions configured such that respective planes tangential to each of the surface regions are disposed at substantially different angles from the axis of rotation of the tip in use. Precursor constructions for use in manufacturing the tips as well as methods for making the precursor constructions and the tips are disclosed.

Abstract: Tools and techniques for migrating applications to compute clouds are described herein. A tool may be used to migrate any arbitrary application to a specific implementation of a compute cloud. The tool may use a library of migration rules, apply the rules to a selected application, and in the process generate migration output. The migration output may be advisory information, revised code, patches, or the like. There may be different sets of rules for different cloud compute platforms, allowing the application to be migrated to different clouds. The rules may describe a wide range of application features and corresponding corrective actions for migrating the application. Rules may specify semantic behavior of the application, code or calls, storage, database instances, interactions with databases, operating systems hosting the application, and others.

Abstract: A tip (20) for a rotary machine tool comprising a superhard structure (12) joined to a cemented carbide substrate 14 by means of at least one intermediate layer (161, 62, 163) disposed between the superhard structure (12) and the cemented carbide substrate (14), the intermediate layer or layers (161, 162, 163) comprising grains of superhard material and grains of a metal carbide material dispersed in a metal binder material.

Abstract: A logical communication path is provided between a target virtual machine (VM) and a host or application communicating with the VM. The target VM runs on a hypervisor host that has a hypervisor and a proxy agent. The hypervisor manages execution of the VM. A mapping is maintained indicating which VMs execute on which hosts. When the host or application is to send a message or packet to the target VM, the mapping is consulted and the hypervisor host hosting the target VM is identified. The message or packet, which may identify the target VM, is transmitted to the hypervisor host. A proxy agent at the hypervisor host selects a communication channel between the hypervisor and the target VM. The hypervisor then passes the message or packet through the selected channel to the target VM.

Abstract: Tools and techniques for migrating applications to compute clouds are described herein. A tool may be used to migrate any arbitrary application to a specific implementation of a compute cloud. The tool may use a library of migration rules, apply the rules to a selected application, and in the process generate migration output. The migration output may be advisory information, revised code, patches, or the like. There may be different sets of rules for different cloud compute platforms, allowing the application to be migrated to different clouds. The rules may describe a wide range of application features and corresponding corrective actions for migrating the application. Rules may specify semantic behavior of the application, code or calls, storage, database instances, interactions with databases, operating systems hosting the application, and others.

Abstract: A pick tool (100) comprising a strike member (110) non-moveably attached to a pick body (120), the strike member comprising a strike structure. The strike structure comprises super-hard material and defines a planar strike surface (112), the strike surface defining a cutting edge (114) that includes an apex (115) in the plane of the strike surface (112). The thickness of at least a proximate volume (107) of the strike structure adjacent the cutting edge (114) is at least about 2 millimeters.

Abstract: Tools and techniques for migrating applications to compute clouds are described herein. A tool may be used to migrate any arbitrary application to a specific implementation of a compute cloud. The tool may use a library of migration rules, apply the rules to a selected application, and in the process generate migration output. The migration output may be advisory information, revised code, patches, or the like. There may be different sets of rules for different cloud compute platforms, allowing the application to be migrated to different clouds. The rules may describe a wide range of application features and corresponding corrective actions for migrating the application. Rules may specify semantic behavior of the application, code or calls, storage, database instances, interactions with databases, operating systems hosting the application, and others.

Abstract: A tip for a pick tool, comprising a polycrystalline diamond (PCD) structure joined to a substrate body. The PCD structure has a strike surface including an apex opposite a boundary with the substrate body. At least an outer volume of the PCD structure contains filler material between diamond grains, the content of the filler material being more than 5 weight percent of the PCD material in the outer volume. The outer volume is proximate at least an area of the strike surface including the apex, and the thickness of the PCD structure between the apex and the boundary with the substrate body is at least 2.5 mm.

Abstract: A pick assembly is provided, comprising a bit assembly and a holder assembly; the bit assembly comprising a bit support body, a fastener mechanism and a deflectable member, cooperatively configured such the deflectable member can be deflected responsive to the progressive coupling of the bit support body to the fastener mechanism. The holder assembly comprises a holder body and is configured for accommodating and retaining the bit assembly by interference means. The holder assembly and bit assembly are cooperatively configured such that the retention of the bit assembly by the holder assembly by interference means can be progressively increased responsive to the progressive coupling of the bit support body with the fastener mechanism when the bit assembly is accommodated by the holder assembly, operative to prevent substantial movement of the bit support body relative to the holder body in use.