Abstract: The present invention provides methods, compositions, and kits for the detection of Early-Stage Alzheimer's disease (AD) autoantibody biomarkers, for the diagnosis of Early-Stage AD, for the identification of a subject at risk for developing Early-Stage AD, and/or for the generation of patient-specific Early-Stage AD autoantibody biomarker profiles.

Abstract: Disclosed are methods, compositions and kits for detecting Multiple Sclerosis (MS) as well as for distinguishing relapsing-remitting (RRMS) and secondary progressive (SPMS) MS subtypes with high overall accuracy. Autoantibody antigens and biomarkers, for the diagnosis of MS in general, RRMS and SPMS, as well as for the identification of a subject at risk for developing MS, and for the generation of patient-specific MS autoantibody biomarker profiles are also provided.

Abstract: Disclosed are methods, compositions and kits for detecting Multiple Sclerosis (MS) as well as for distinguishing relapsing-remitting (RRMS) and secondary progressive (SPMS) MS subtypes with high overall accuracy. Autoantibody antigens and biomarkers, for the diagnosis of MS in general, RRMS and SPMS, as well as for the identification of a subject at risk for developing MS, and for the generation of patient-specific MS autoantibody biomarker profiles are also provided.

Abstract: The present invention provides methods, compositions, and kits for the detection of neurodegenerative disease specific autoantibodies for the diagnosis of neurodegenerative diseases and risk for developing neurodegenerative diseases, and for the generation of patient-specific neurodegenerative disease diagnostic autoantibody profiles.

Abstract: A radar system includes a transmit section to emit a transmit signal. A chip-based front-end portion of the transmit section increases a frequency of an input signal to produce an intermediate signal and amplifies signal strength of the intermediate signal to produce the transmit signal. The frequency of the input signal is in a range of 76 gigahertz (GHz) to 80 GHz. The radar system also includes a receive section to receive a reflected signal resulting from reflection of the transmit signal by an object.

Abstract: The present invention relates to diagnostic methods, reagents, and kits for detecting and diagnosing Early Stage Parkinson's disease.

Abstract: A radar system with frequency conversion includes a signal generator configured to generate an input signal at a first frequency. A transmitting interposer is configured to receive the input signal from the signal generator. The transmitting interposer includes a transmitting front-end module configured to upconvert the input signal at the first frequency to an outgoing radar signal at a second frequency greater than the first frequency, and a transmitting antenna module having a plurality of transmitting patches configured to radiate the outgoing radar signal. A receiving interposer is configured to transmit an output signal to the signal generator. The receiving interposer includes a receiving antenna module having a plurality of receiving patches configured to capture an incoming radar signal at the second frequency, and a receiving front-end module configured to downconvert the incoming radar signal at the second frequency to the output signal at the first frequency.

Abstract: A radar system includes a transmit section to emit a transmit signal. A chip-based front-end portion of the transmit section increases a frequency of an input signal to produce an intermediate signal and amplifies signal strength of the intermediate signal to produce the transmit signal. The frequency of the input signal is in a range of 76 gigahertz (GHz) to 80 GHz. The radar system also includes a receive section to receive a reflected signal resulting from reflection of the transmit signal by an object.

Abstract: Disclosed are methods, compositions and kits for detecting Multiple Sclerosis (MS) as well as for distinguishing relapsing-remitting (RRMS) and secondary progressive (SPMS) MS subtypes with high overall accuracy. Autoantibody antigens and biomarkers, for the diagnosis of MS in general, RRMS and SPMS, as well as for the identification of a subject at risk for developing MS, and for the generation of patient-specific MS autoantibody biomarker profiles are also provided.

Abstract: The present invention provides methods, compositions, and kits for the detection of Early-Stage Alzheimer's disease (AD) autoantibody biomarkers, for the diagnosis of Early-Stage AD, for the identification of a subject at risk for developing Early-Stage AD, and/or for the generation of patient-specific Early-Stage AD autoantibody biomarker profiles.

Abstract: A receiver apparatus is provided. The apparatus includes a single field effect transistor mixer comprising a gate, a source and a drain, wherein one of the source or the drain is configured to receive a first signal from a first low noise amplifier at a receiving frequency and another of the source or the drain is configured to output a second signal at an intermediate frequency to a second low noise amplifier; and a local oscillator configured to apply a third signal to the gate.

Abstract: The present invention provides methods, compositions and kits for the detection of Alzheimer's disease (AD) diagnostic biomarkers, for the diagnosis of AD, for the identification of a subject at risk for developing AD, and for the generation of patient-specific AD diagnostic biomarker profiles.

Abstract: A radar system with frequency conversion includes a signal generator configured to generate an input signal at a first frequency. A transmitting interposer is configured to receive the input signal from the signal generator. The transmitting interposer includes a transmitting front-end module configured to upconvert the input signal at the first frequency to an outgoing radar signal at a second frequency greater than the first frequency, and a transmitting antenna module having a plurality of transmitting patches configured to radiate the outgoing radar signal. A receiving interposer is configured to transmit an output signal to the signal generator. The receiving interposer includes a receiving antenna module having a plurality of receiving patches configured to capture an incoming radar signal at the second frequency, and a receiving front-end module configured to downconvert the incoming radar signal at the second frequency to the output signal at the first frequency.

Abstract: The present invention relates to diagnostic methods, reagents, and kits for detecting and diagnosing Early Stage Parkinson's disease.

Abstract: The present invention relates to diagnostic methods, reagents, and kits for detecting and diagnosing Early Stage Parkinson's disease.

Abstract: The present invention provides methods, compositions, and kits for the detection of neurodegenerative disease specific autoantibodies for the diagnosis of neurodegenerative diseases and risk for developing neurodegenerative diseases, and for the generation of patient-specific neurodegenerative disease diagnostic autoantibody profiles.

Abstract: The present invention provides methods, compositions and kits for the detection of Alzheimer's disease (AD) diagnostic biomarkers, for the diagnosis of AD, for the identification of a subject at risk for developing AD, and for the generation of patient-specific AD diagnostic biomarker profiles.

Abstract: The present invention provides methods, compositions and kits for the detection of Alzheimer's disease (AD) diagnostic biomarkers, for the diagnosis of AD, for the identification of a subject at risk for developing AD, and for the generation of patient-specific AD diagnostic biomarker profiles.

Abstract: The present invention relates novel slice culture systems which provide a quick, simple, and effective tool for investigating pathological changes associated with AD. Also provided are methods of diagnosing AD and identifying potentially therapeutic compounds.

Abstract: An electronic circuit comprising: an integrated circuit chip, the integrated circuit chip having a top face; portions of the top face of the chip being covered by a first metal layer electrically connected to the integrated circuit; and a dialectic layer formed on the top face of the chip beside and on top of said first metal layer; wherein the dielectric layer extends parallel to the top face of the chip beyond the edges of the chip, the first metal layer extending in the dielectric layer beyond the edges of the chip; and wherein portions of a top surface of the dielectric layer are covered by a second metal layer, portions of the first and second metal layers being electrically connected through the dielectric layer.