Abstract: Recombinant expression systems for the production of proteins, and particularly a system for rapidly generating recombinant silkworm baculoviruses. Bombyx mori nuclear polyhedrosis virus (BmNPV) with an efficiency approaching 100% has been developed. In a specific example, the vector of the invention was used to generate expression of a FLAG-epitope tagged HIV tat interacting protein of 30 kDa (f-TIP30) in BmN cells and silkworm larvae.

Abstract: Histone acetyltransferase inhibitors, especially those that are differentiate between p300 and PCAF histone acetyltransferase; also therapeutic processes comprising their administration to humans.

Abstract: Isolated nucleic acid molecules encoding Thyroid Receptor-Associated Proteins (TRAPS) are provided. TRAPS are members of protein complexes that bind to nuclear hormone receptors in a ligand-dependent manner so that the receptor, upon activation by a corresponding hormone, regulates the transcription of a particular gene. Also provided are methods of replicating and expressing such isolated nucleic acid molecules, pharmaceutical compositions comprising TRAPS, and methods of modulating gene expression via administration of therapeutically effective amounts of such pharmaceutical compositions.

Abstract: Methods of isolating and characterizing Tat-interacting proteins (TIPs) are disclosed. These Tat-interacting proteins comprise a material selected from the group consisting of a protein, active fragments thereof, agonists thereof, mimics thereof, and combinations thereof, said protein having the following characteristics:a) it binds with the activation domain of the HIV-1 regulatory protein Tat and stimulates transactivation by Tat andb) it possesses an apparent molecular weight of approximately 30 kDa or 56 kDa as determined by SDS-polyacrylamide gel electrophoresis.