Abstract: The invention provides a method of inhibiting neovascularization in a subject. The method comprises administering to the subject an agent that interferes with fibronectin (Fn) matrix assembly in an amount effective to inhibit neovascularization. The invention also provides a method of identifying an agent that inhibits neovascularization. The method comprises detecting fibronectin (Fn) matrix assembly by stimulated endothelial cells cultured in three-dimensional culture gel in the presence and absence of an agent. A decrease in Fn matrix assembly in the presence of the agent compared to Fn matrix assembly in the absence of the agent is indicative of an agent that inhibits neovascularization. Alternatively, the method of identifying an agent that inhibits neovascularization comprises detecting changes in nuclear architecture in stimulated endothelial cells cultured in three-dimensional culture gel in the presence and absence of an agent.

Abstract: The invention provides a method of inhibiting neovascularization in a subject. The method comprises administering to the subject an agent that interferes with fibronectin (Fn) matrix assembly in an amount effective to inhibit neovascularization. The invention also provides a method of identifying an agent that inhibits neovascularization. The method comprises detecting fibronectin (Fn) matrix assembly by stimulated endothelial cells cultured in three-dimensional culture gel in the presence and absence of an agent. A decrease in Fn matrix assembly in the presence of the agent compared to Fn matrix assembly in the absence of the agent is indicative of an agent that inhibits neovascularization. Alternatively, the method of identifying an agent that inhibits neovascularization comprises detecting changes in nuclear architecture in stimulated endothelial cells cultured in three-dimensional culture gel in the presence and absence of an agent.

Abstract: A textile fiber recycling machine for reprocessing hard thread waste, woven and non-woven fabrics, carpets, rugs, and the like. Material to be recycled is fed in pieces, or in roll form, into the machine. The machine includes a plurality of wire wound rolls positioned adjacent to one another and operating at successively higher rotational speeds from the inlet side to the outlet side of the machine. Closely spaced adjacent the rollers are carding segments. The rollers downstream of the entry roller include pairs of carding segments, with the leading carding segment being wire clothed, and the trailing carding segment being covered with a granular covering, such as sandpaper. The machine outputs open, usable fibers which can be used in subsequent conventional textile processes. A method of attaching sandpaper to a carding segment is also disclosed.

Abstract: A combination tool device having a double ended socket wrench, a handle with a screwdriver tip, and a file disposed in the handle is provided. The file may be removed from the handle and used as a separate tool, or may be first removed and then releasably reconnected so that the other components function as a file handle. The file may also be disposed so that it is stored in the handle and may be extended and releasably fixed in extended position for use.