Abstract: A method of enhancing therapeutic/drug transport to the perivascular space of the brain of a patient is disclosed. In one embodiment, the method comprises the step of introducing a therapeutic/drug and an osmolyte of the present invention into a patient's cerebrospinal fluid (CSF), wherein the osmolyte is introduced to the CSF at a concentration of between 0.5 and 12.9 M (dependent on the solubility upper limit of the osmolyte), and wherein the therapeutic/drug delivery to the perivascular spaces of cerebral blood vessels and parenchyma of the central nervous system is facilitated by the presence of the osmolyte.

Abstract: A method of enhancing therapeutic/drug transport to the perivascular space of the brain of a patient is disclosed. In one embodiment, the method comprises the step of introducing a therapeutic/drug and an osmolyte of the present invention into a patient's cerebrospinal fluid (CSF), wherein the osmolyte is introduced to the CSF at a concentration of between 0.5 and 12.9 M (dependent on the solubility upper limit of the osmolyte), and wherein the therapeutic/drug delivery to the perivascular spaces of cerebral blood vessels and parenchyma of the central nervous system is facilitated by the presence of the osmolyte.

Abstract: A foot and ankle protective apparatus provides support and protection with simultaneous pliability. The apparatus is especially helpful to those who have recently had a cast removed and still require protection of the applicable area while allowing for walking. The apparatus comprises a thick, durable sole. Pliable leg, ankle and foot support is provided. The foot cover shell covers a stadium plate shaped cushion with a convex outer for fit to the identical shape of the shell. The concave inner of the cushion provides for comfortable fit to the top of the foot. The ankle opening between the foot surrounds and the leg surround overlaps allows for limited dorsi flexion and plantar flexion of the ankle, while still providing ankle support both laterally and against extreme flexion. The apparatus is especially useful in lieu of total immobilization.