Patents by Inventor Robert G. Wolfangel
Robert G. Wolfangel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5690908Abstract: Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging.Type: GrantFiled: November 13, 1995Date of Patent: November 25, 1997Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, William P. Cacheris, William H. Ralston, David H. White, Dennis L. Nosco, Robert G. Wolfangel, Janet Braddock Wilking, Linda Meeh, Steven R. Woulfe
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Patent number: 5609850Abstract: Treated apatite particles are disclosed for enhancing radical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging.Type: GrantFiled: August 22, 1995Date of Patent: March 11, 1997Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, William P. Cacheris, William H. Ralston, David H. White, Dennis L. Nosco, Robert G. Wolfangel, Janet B. Wilking, Linda Meeh, Steven R. Woulfe
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Patent number: 5595724Abstract: Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.Type: GrantFiled: January 13, 1995Date of Patent: January 21, 1997Inventors: Edward A. Deutsch, Karen F. Deutsch, Dennis L. Nosco, William H. Ralston, David H. White, Janet B. Wilking, Robert G. Wolfangel, Steven R. Woulfe, William P. Cacheris, Linda Meeh
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Patent number: 5468465Abstract: Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging (37 MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging.Type: GrantFiled: July 6, 1994Date of Patent: November 21, 1995Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, William P. Cacheris, William H. Ralston, David H. White, Dennis L. Nosco, Robert G. Wolfangel, Janet B. Wilking, Linda Meeh, Steven R. Woulfe
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Patent number: 5407659Abstract: Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.Type: GrantFiled: April 13, 1993Date of Patent: April 18, 1995Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, Dennis L. Nosco, William H. Ralston, David H. White, Janet B. Wilking, Robert G. Wolfangel, Steven R. Woulfe
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Patent number: 5382388Abstract: Process for preparing a radionuclide generator for producing Tc-99m or Re-188. A clear solution containing a metallic cation and an anion comprising W-188 or Mo-99 is provided. The metallic cation is present in the solution as a dissolved complex of the metallic cation and a complexing agent and/or the anion being present in the solution as a dissolved complex of the anion and a complexing agent. The dissolved complex(es) are decomposed to form a slurry containing a precipitate of the metallic cation and the anion. The precipitate is transferred to an elutable container of a radionuclide generator.Type: GrantFiled: August 21, 1992Date of Patent: January 17, 1995Assignees: Curators of University of Missouri, Mallinckrodt Medical, Inc.Inventors: Gary J. Ehrhardt, Robert G. Wolfangel, Edward A. Deutsch
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Patent number: 5344640Abstract: Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging.Type: GrantFiled: September 22, 1992Date of Patent: September 6, 1994Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, William P. Cacheris, William H. Ralston, David H. White, Dennis L. Nosco, Robert G. Wolfangel, Janet B. Wilking, Linda Meeh, Steven R. Woulfe
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Patent number: 5219556Abstract: A method of preparing a stable, therapeutic radiopharmaceutical composition comprised of an alpha- or beta-emitting radionuclide and a ligand by lyophilizing a solution of the complex. The radionuclide preferably has a half-life of at least twelve hours. The invention also is directed to stable lyophilized radiopharmaceutical compositions prepared by this method. The invention is particularly suited to the preparation of radionuclide-labeled antibodies in a stable form which merely requires reconstitution at the point of use.Type: GrantFiled: July 9, 1990Date of Patent: June 15, 1993Assignee: Mallinckrodt Medical, Inc.Inventor: Robert G. Wolfangel
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Patent number: 4075314Abstract: Improved stannous pyrophosphate technetium-99m compositions.Type: GrantFiled: April 29, 1976Date of Patent: February 21, 1978Assignee: Mallinckrodt, Inc.Inventors: Robert G. Wolfangel, Howard A. Anderson
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Patent number: 4062933Abstract: An improved process for lyophilizing pharmaceutical products capable of being labelled with a radionuclide.Type: GrantFiled: May 27, 1975Date of Patent: December 13, 1977Assignee: Mallinckrodt, Inc.Inventor: Robert G. Wolfangel
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Patent number: 4057616Abstract: Metal hydroxides such as Fe(OH).sub.2, Fe(OH).sub.3 and Sn(OH).sub.2 are prepared in the form of spherical particles of uniform and controlled size suitable for tagging with a radioactive element such as technetium-99m. Aqueous suspensions of such tagged particles are useful in scintigraphy as lung scanning agents.Type: GrantFiled: November 7, 1975Date of Patent: November 8, 1977Assignee: Mallinckrodt, Inc.Inventor: Robert G. Wolfangel
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Patent number: 3962412Abstract: Metal hydroxides such as Fe(OH).sub.2, Fe(OH).sub.3 and Sn(OH).sub.2 are prepared in the form of spherical particles of uniform and controlled size suitable for tagging with a radioactive element such as technetium-99m. Aqueous suspensions of such tagged particles are useful in scintigraphy as lung scanning agents.Type: GrantFiled: June 11, 1973Date of Patent: June 8, 1976Assignee: Mallinckrodt Chemical WorksInventor: Robert G. Wolfangel