Abstract: A lead device is provided for a medical treatment apparatus, where the lead device includes protruding anchoring mechanisms for anchoring the lead device in tissue. The anchoring mechanism include permanent anchoring mechanisms, or a combination of permanent and dissolvable anchoring mechanisms, to anchor the device in tissue. The anchoring mechanism resists migration of the lead device in at least one or both axial directions.

Abstract: A lead device is provided for a medical treatment apparatus, where the lead device includes protruding anchoring mechanisms for anchoring the lead device in tissue. The anchoring mechanism include permanent anchoring mechanisms, or a combination of permanent and dissolvable anchoring mechanisms, to anchor the device in tissue. The anchoring mechanism resists migration of the lead device in at least one or both axial directions.

Abstract: Embodiments provide implant housings (IH) having embedded suture anchors comprising a suture anchor loop (SAL) with an anchoring element each end. The SAL allows a suture to be passed through the loop to anchor the housing to selected tissue. Particular embodiments provide IHs having embedded sutures wherein the suture is embedded in a cured portion (CP) of the housing wall (HW). The suture may be part of a suture assembly having a first and second end portion (EP) and a mid-portion (MP) each of the EP's including an anchoring portion (AP). At least a portion of the HW comprises a cured portion (CP). The first and second SA EP's are embedded in the CP such that the MP forms a loop extending out from the HW outer surface. The embedded AE is configured such that a force for pulling the suture out of the CP exceeds a suture tensile strength.

Abstract: A method determines an analyte concentration in a sample. The sample includes the analyte and a substance. The method includes providing absorption data of the sample. The method further includes providing reference absorption data of the substance. The method further includes calculating a substance contribution of the absorption data. The method further includes subtracting the substance contribution from the absorption data, thereby providing corrected absorption data substantially free of a contribution from the substance.

Abstract: Disclosed herein is a system for estimating the concentration of an analyte in a material sample. The system comprises a source of electromagnetic radiation; a detector positioned to detect radiation emitted by the source, so that the source and the detector define an optical path therebetween; and a sample element configured to be positioned in the optical path. The sample element comprises a sample chamber at least partially defined by opposed first and second windows which are substantially transmissive of at least a portion of the radiation emitted by the source, and which define an optical pathlength through the sample element. The sample chamber has an internal volume of less than 2 microliters. When the material sample is positioned in the sample chamber and the sample chamber is positioned in the optical path, the system computes estimated concentrations of the analyte in the material sample.