Patents by Inventor Robert Gary Thorne

Robert Gary Thorne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for enhancing intranasal delivery of therapeutic agents
    Patent number: 10220097
    Abstract: A method for treating a patient suffering from a condition with an active compound comprising the steps of (a) treating the patient intranasally with an effective amount of MMP-9 or a functionally equivalent fragment, wherein the tight junctions of the patient's nasal epithelial cells are modulated or wherein the basal lamina of the patient is partially digested and type IV collagen of the patient is degraded or wherein access to the patient's perineural, perivascular, or lymphatic compartment spaces is facilitated and (b) treating the patient intranasally with an active compound is disclosed.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: March 5, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Robert Gary Thorne, Jeffrey James Lochhead
  • Methods and Compositions for Enhancing Intranasal Delivery of Therapeutic Agents
    Publication number: 20160243245
    Abstract: A method for treating a patient suffering from a condition with an active compound comprising the steps of (a) treating the patient intranasally with an effective amount of MMP-9 or a functionally equivalent fragment, wherein the tight junctions of the patient's nasal epithelial cells are modulated or wherein the basal lamina of the patient is partially digested and type IV collagen of the patient is degraded or wherein access to the patient's perineural, perivascular, or lymphatic compartment spaces is facilitated and (b) treating the patient intranasally with an active compound is disclosed.
    Type: Application
    Filed: February 19, 2016
    Publication date: August 25, 2016
    Inventors: Robert Gary Thorne, Jeffrey James Lochhead
  • Methods and compositions for enhancing intranasal delivery of therapeutic agents
    Patent number: 9320800
    Abstract: A method for treating a patient suffering from a condition with an active compound comprising the steps of (a) treating the patient intranasally with an effective amount of MMP-9 or a functionally equivalent fragment, wherein the tight junctions of the patient's nasal epithelial cells are modulated or wherein the basal lamina of the patient is partially digested and type IV collagen of the patient is degraded or wherein access to the patient's perineural, perivascular, or lymphatic compartment spaces is facilitated and (b) treating the patient intranasally with an active compound is disclosed.
    Type: Grant
    Filed: August 14, 2013
    Date of Patent: April 26, 2016
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Robert Gary Thorne, Jeffrey James Lochhead
  • Methods and Compositions for Enhancing Intranasal Delivery of Therapeutic Agents
    Publication number: 20140050718
    Abstract: A method for treating a patient suffering from a condition with an active compound comprising the steps of (a) treating the patient intranasally with an effective amount of MMP-9 or a functionally equivalent fragment, wherein the tight junctions of the patient's nasal epithelial cells are modulated or wherein the basal lamina of the patient is partially digested and type IV collagen of the patient is degraded or wherein access to the patient's perineural, perivascular, or lymphatic compartment spaces is facilitated and (b) treating the patient intranasally with an active compound is disclosed.
    Type: Application
    Filed: August 14, 2013
    Publication date: February 20, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Robert Gary Thorne, Jeffrey James Lochhead
  • Method for administering agents to the central nervous system
    Patent number: 7273618
    Abstract: The present invention is directed to a method for delivering agents to the central nervous system by way of a tissue innervated by the trigeminal nerve that is outside the nasal cavity. Such a method of delivery can be useful in the treatment of central nervous system and/or brain disorders.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: September 25, 2007
    Assignee: Chiron Corporation
    Inventors: William H. Frey, II, Robert Gary Thorne
  • Method for administering agents to the central nervous system
    Publication number: 20030072793
    Abstract: The present invention is directed to a method for delivering agents to the central nervous system by way of a tissue innervated by the trigeminal nerve that is outside the nasal cavity. Such a method of delivery can be useful in the treatment of central nervous system and/or brain disorders.
    Type: Application
    Filed: November 21, 2002
    Publication date: April 17, 2003
    Applicant: Chiron Corporation
    Inventors: William H. Frey, Robert Gary Thorne