Abstract: Compounds, compositions, and methods for generating T cells with altered phenotype are disclosed. The phenotype-altered T cells have increased persistence, prolonged survival, and increased antitumor activity and are useful for treatment of cancers.

Abstract: The present invention relates to a chimeric costimulatory antigen receptor (CoStAR) useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. The CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. The present invention also provides CoStAR proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof.

Abstract: Provided herein are methods for the treatment, mitigation, and prevention of viral infections (e.g., coronavirus infections (e.g., severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), etc.), etc.) and diseases (e.g., Coronavirus disease 2019 (COVID-19)) associated therewith by the administration of cysteamine or derivatives thereof to a subject.

Abstract: In some embodiments, a system may reduce contaminants in water. A system may include a biofilm in a container. The biofilm may be formed from one or more bacteria coupled to one or more substrates. The bacteria may be selected to maximize the reduction of contaminants in water. The system may include one or more bacteria generators to provide bacteria to the biofilm and/or one or more air sources to provide an air bubble stream to the container and/or the bacteria generator. In some embodiments, bacteria may be preserved in a starvation phase. Bacteria may be incubated until they reach a starvation phase. The bacteria may then be preserved as beads or immobilized on a substrate. The preserved bacteria may be used in a system for the reduction of contaminants in water.

Abstract: A closure device which a consumer or bag manufacturer may affix to most any bag comprises an elongated first strip of flexible material and a thin bendable wire and second strip of material of substantially the same length as the first strip and longitudinally aligned with and affixed to the first strip. The first strip includes an opposite adhesive surface which is covered by a protective strip of release paper at the time of manufacture. A plurality of individual closure devices may be manufactured in sheet form with perforations extending between each adjacent closure device on the sheet. When needed, the consumer tears a closure device from the sheet. The consumer peels away the release paper revealing the adhesive surface and affixes the closure device to the outer surface of a bag. In one preferred method, the consumer affixes the closure device in a traversing manner with the closure device extending between the opposite closed and open ends of the bag.

Abstract: In some embodiments, a system may reduce contaminants in water. A system may include a biofilm in a container. The biofilm may be formed from one or more bacteria coupled to one or more substrates. The bacteria may be selected to maximize the reduction of contaminants in water. The system may include one or more bacteria generators to provide bacteria to the biofilm and/or one or more air sources to provide an air bubble stream to the container and/or the bacteria generator. In some embodiments, bacteria may be preserved in a starvation phase. Bacteria may be incubated until they reach a starvation phase. The bacteria may then be preserved as beads or immobilized on a substrate. The preserved bacteria may be used in a system for the reduction of contaminants in water.

Abstract: Systems, methods, and media for controlling the exposure of orders to trading platforms are provided. In accordance with some embodiments, systems for controlling the exposure of orders to trading platforms are provided, the systems comprising: at least one hardware processor that: receives information for at least one order to trade a security; and for each of a plurality of trading platforms, determines how the at least one order is to be exposed to trading platform based on at least one of a default exposure setting for all orders for the trading platform, at least one filter for the trading platform, and an exposure status setting for the trading platform and the at least one order, and provides information for the at least one order to the trading platform.

Abstract: In some embodiments, a system may reduce metal compounds from water. A system may include alginate particles in a housing. The alginate particles may be formed by directly adding alginate granules to an aqueous solution comprising metal ions, such as calcium ions.

Abstract: In some embodiments, a system may reduce contaminants in water. A system may include a biofilm in a container. The biofilm may be formed from one or more bacteria coupled to one or more substrates. The bacteria may be selected to maximize the reduction of contaminants in water. The system may include one or more bacteria generators to provide bacteria to the biofilm and/or one or more air sources to provide an air bubble stream to the container and/or the bacteria generator. In some embodiments, bacteria may be preserved in a starvation phase. Bacteria may be incubated until they reach a starvation phase. The bacteria may then be preserved as beads or immobilized on a substrate. The preserved bacteria may be used in a system for the reduction of contaminants in water.

Abstract: In some embodiments, a system may reduce contaminants in water. A system may include a biofilm in a container. The biofilm may be formed from one or more bacteria coupled to one or more substrates. The bacteria may be selected to maximize the reduction of contaminants in water. The system may include one or more bacteria generators to provide bacteria to the biofilm and/or one or more air sources to provide an air bubble stream to the container and/or the bacteria generator. In some embodiments, bacteria may be preserved in a starvation phase. Bacteria may be incubated until they reach a starvation phase. The bacteria may then be preserved as beads or immobilized on a substrate. The preserved bacteria may be used in a system for the reduction of contaminants in water.

Abstract: In some embodiments, a system may reduce contaminants in water. A system may include a biofilm in a container. The biofilm may be formed from one or more bacteria coupled to one or more substrates. The bacteria may be selected to maximize the reduction of contaminants in water. The system may include one or more bacteria generators to provide bacteria to the biofilm and/or one or more air sources to provide an air bubble stream to the container and/or the bacteria generator. In some embodiments, bacteria may be preserved in a starvation phase. Bacteria may be incubated until they reach a starvation phase. The bacteria may then be preserved as beads or immobilized on a substrate. The preserved bacteria may be used in a system for the reduction of contaminants in water.

Abstract: In some embodiments, a system may reduce contaminants in water. A system may include a biofilm in a container. The biofilm may be formed from one or more bacteria coupled to one or more substrates. The bacteria may be selected to maximize the reduction of contaminants in water. The system may include one or more bacteria generators to provide bacteria to the biofilm and/or one or more air sources to provide an air bubble stream to the container and/or the bacteria generator. In some embodiments, bacteria may be preserved in a starvation phase. Bacteria may be incubated until they reach a starvation phase. The bacteria may then be preserved as beads or immobilized on a substrate. The preserved bacteria may be used in a system for the reduction of contaminants in water.

Abstract: An LED excitation source and module useful for full plate imaging fluorescence instruments as well as methods for calibrating such instruments.

Abstract: Methods and apparatus for performing error compensation by modifying encoder-type position feedback signals supplied to a machine tool controller is illustrated by four embodiments. The first embodiment inserts compensation pulses into position feedback signals by using OR gates, when both square waves of the feedback signals are logically low. The addition or subtraction of the compensation pulses is performed by inserting the compensation pulses at a particular phase relative to each other. The second embodiment is capable of inserting correction pulses when the square waves are in any logical state. The third embodiment is capable of correcting the error completely controlling the feedback signals and not using OR gates to insert correction pulses, but requires a faster microcomputer. The fourth embodiment uses inverters incorporated sequentially, instead of OR gates, to invert the square wave signals before they are supplied to the machine tool controller.