Abstract: Described herein are methods for the identification and detection of genetic factors in the molecular pathways associated with vascular retinopathies or retinal diseases, for example mild, moderate or severe retinopathy of prematurity (ROP). Included herewith are methods of detecting genetic mutations associated with severe retinopathies, including factors in ADR?2 pathways, which include RAPGEF3, ADCY7, ADCY9, PRKARIA, and ADCY4 variants. Further, this disclosure provides for methods of treating a subject having a detected genetic factor indicative of ROP.

Abstract: A method for integrating assets of an automated system includes defining base services of the automated system. A directory of assets within the automated system is provided. A common name space associated with each asset in the directory is also provided. Each asset in the directory is linked using the common name space. The assets are integrated by extending at least one asset to another asset to perform a base service of the automated system.

Abstract: Methods and systems for normalizing client access to data are provided. In one aspect, a method for accessing data in an automation system is provided. The method includes publishing at least one resource for at least one device and transmitting, from a client to the at least one device, a request to identify any available operations for the at least one published resource. The method also includes transmitting to the client a user interface generated by the at least one device in response to a client request for information relating to a chosen operation of the at least one published resource, and displaying results of the chosen operation in response to a client request to execute the chosen operation.

Abstract: A method for normalizing client interactions with service providers is provided. The method includes receiving a request for a desired service provider method interface from a client, searching a directory for an extender that is associated with the desired service provider method, and returning a proxy to the client, the proxy including at least one of an extender execution path and a method execution path.

Abstract: A method for controlling access to a system is provided. The method includes creating a role tree including a plurality of privileges, creating a resource tree including a plurality of resources, assigning at least one role for at least one resource to a user, and evaluating the plurality of privileges of the user for a requested service access based on at least one of a user role assignment, a user resource assignment, and a location of a device used by the user to request the service access.