Patents by Inventor Robert Gerhardus Jacob VRIES

Robert Gerhardus Jacob VRIES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BINDING MOLECULES THAT INHIBIT CANCER GROWTH
    Publication number: 20240343824
    Abstract: The invention provides means and methods for inhibiting growth of a cancer. The means in some embodiments comprise proteins and antibodies that binds an extracellular part of a membrane associated member of the epidermal growth factor (EGF) receptor family and an extracellular part of a membrane associated member of a WNT signaling pathway. Further provided are various cells and assays that are helpful in the production of the proteins, antibodies and cells.
    Type: Application
    Filed: February 2, 2024
    Publication date: October 17, 2024
    Inventors: Mark THROSBY, Ton LOGTENBERG, Johannes Carolus CLEVERS, Robert Gerhardus Jacob VRIES, Eduard BATLLE, Bram HERPERS
  • Organoid-Derived Monolayers and Uses Thereof
    Publication number: 20240240155
    Abstract: The invention relates to culture methods, in particular methods of obtaining organoid-derived monolayers, and to uses of the organoid-derived monolayers obtained by said methods. The invention also relates to assays for epithelial barrier function and methods of screening compounds using said assays.
    Type: Application
    Filed: July 11, 2022
    Publication date: July 18, 2024
    Applicant: Hub Organoids IP B.V.
    Inventors: Farzin Pourfarzad, Merel Derksen, Alessandra Merenda, Sylvia Fernandez-Boj, Robert Gerhardus Jacob Vries
  • Binding molecules that inhibit cancer growth
    Patent number: 11939394
    Abstract: The invention provides means and methods for inhibiting growth of a cancer. The means in some embodiments comprise proteins and antibodies that binds an extracellular part of a membrane associated member of the epidermal growth factor (EGF) receptor family and an extracellular part of a membrane associated member of a WNT signaling pathway. Further provided are various cells and assays that are helpful in the production of the proteins, antibodies and cells.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: March 26, 2024
    Assignees: Merus N.V., Fundacio Institut de Recerca Biomedica, Institució Catalana de Recerca I Estudis Avancats
    Inventors: Mark Throsby, Ton Logtenberg, Johannes Carolus Clevers, Robert Gerhardus Jacob Vries, Eduard Batlle, Bram Herpers
  • IMMUNE CELL ORGANOID CO-CULTURES
    Publication number: 20210208131
    Abstract: The present invention provides co-cultures of organoids and immune cells, and methods of using these to identify agents for treating diseases.
    Type: Application
    Filed: December 21, 2018
    Publication date: July 8, 2021
    Applicants: Koninklijke Nederlandse Akademie van Wetenschappen, Stichting Hubrecht Organoid Technology
    Inventors: Kai Kretzschmar, Jotam Elazar Bar-Ephraim, Johannes Carolus Clevers, Sylvia Fernandez-Boj, Robert Gerhardus Jacob Vries
  • BINDING MOLECULES THAT INHIBIT CANCER GROWTH
    Publication number: 20180312604
    Abstract: The invention provides means and methods for inhibiting growth of a cancer. The means in some embodiments comprise proteins and antibodies that binds an extracellular part of a membrane associated member of the epidermal growth factor (EGF) receptor family and an extracellular part of a membrane associated member of a WNT signaling pathway. Further provided are various cells and assays that are helpful in the production of the proteins, antibodies and cells.
    Type: Application
    Filed: October 21, 2016
    Publication date: November 1, 2018
    Inventors: Mark THROSBY, Ton LOGTENBERG, Johannes Carolus Clevers, Robert Gerhardus Jacob VRIES, Eduard BATLLE, Bram HERPERS