Abstract: A cap for a depilatory composition product container which comprises a product application surface to dispense the composition onto the skin of the user, and a product removal edge for scraping the cream from the skin of the user, such that the cap can function both as product applicator and product residue collector.

Abstract: A crystallization process for preparing a polymorph of rosiglitazone maleate (Compound 1), and a process for preparing Compound 1 with a polymorphic purity that is suitable for use as a seed material in a crystallization process for preparing Compound 1.

Abstract: The present invention relates to novel heterocyclyl-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Abstract: A process for preparing a compound of formula (I): or a tautomeric form thereof or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein: A1 represents a substituted or unsubstituted aromatic heterocyclyl group; R1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; A2 represents a benzene ring having in total up to five substituents; and n represents an integer in the range of from 2 to 6, which process comprises catalytically reducing a compound of formula (II): wherein A1, R1, A2 and n are as defined in relation to formula (I), characterised in that the reduction reaction is carried out using a hydrogen pressure above 20 psi; and thereafter if required forming a pharmaceutically acceptable salt and/or a pharmaceutically acceptable solvate of the compound of formula (I).

Abstract: A polymorphic form of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt (the “Polymorph”) characterised in that it provides: (i) an infra red spectrum containing peaks at 1752, 1546, 1154, 621, and 602 cm?1; and/or (ii) a Raman spectrum containing peaks at 1751, 1243 and 602 cm?1; and/or (iii) a solid-state nuclear magnetic resonance spectrum containing peaks at 111.9, 114.8, 119.6, 129.2, 134.0, 138.0, 144.7, 153.2, 157.1, 170.7, 172.0, and 175.0 ppm; and/or (iv) an X-ray powder diffraction (XRPD) pattern which gives calculated lattice spacings of 6.46, 5.39, 4.83, 4.68, 3.71, 3.63, 3.58, and 3.48 Angstroms; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.

Abstract: A process for preparing a compound of formula (I): or a tautomeric form thereof or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein: A1 represents a substituted or unsubstituted aromatic heterocyclyl group; R1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; A2 represents a benzene ring having in total up to five substituents; and n represents an integer in the range of from 2 to 6, which process comprises catalytically reducing a compound of formula (II): wherein A1, R1, A2 and n are as defined in relation to formula (I), characterised in that the reduction reaction is carried out using a hydrogen pressure above 20 psi; and thereafter if required forming a pharmaceutically acceptable salt and/or a pharmaceutically acceptable solvate of the compound of formula (I).

Abstract: The present invention provides methods and compositions for analyzing compromised nucleic acid samples. The present invention also includes methods of selecting panels and panels of single nucleotide polymorphisms that are selected so as to be outside of tandem repeat regions, and are not genetically linked.

Abstract: A polymorphic form of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt (the “Polymorph”) characterized in that it provides: (i) an infra red spectrum containing peaks at 1763, 912, 856 and 709 cm?1; and/or (ii) a Raman spectrum containing peaks at 1762, 1284, 912 and 888 cm?1; and/or (iii) a solid-state 13C nuclear magnetic resonance spectrum containing peaks at 111.0, 113.6, 119.8, 129.1, 130.9, 131.8, 134.7, 138.7, 146.5, 152.7, 157.5, 169.5, 171.0, 178.7 ppm; and/or (iv) an X-ray powder diffraction (XRPD) pattern which gives calculated lattice spacings at 5.87, 5.30, 4.69, 4.09, 3.88, 3.61, 3.53, and 3.46 Angstroms; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.

Abstract: A paper cutter assembly for a printer/plotter is mounted on the printhead carriage for movement therewith to avoid separate mounting and guide structure. A cutter wheel is mounted in a housing for cam induced movement between a raised inactive position and a lower active position by engagement of a cam element carrier mounted for movement in the cutter housing with structure on the printer chassis. The printer platen has a stationary cutter bar which extends in a channel in the platen transversely of the path of paper movement and has a cutter wheel receiving well at one end of the channel into which the cutter wheel drops without contacting the platen or cutter bar at commencement of a cutting operation. Camming surfaces on the platen engage the side of a cutter drive wheel to move the cutter wheel into engagement with the cutter bar and then to raise the cutter wheel to the proper amount of operational overlap of the cutting edges as the cutter assembly moves across the paper path.

Abstract: To assemble a printer chassis comprising three structural aluminium beams extending between two structural sideplates, the printer carriage beam is first attached to the sideplates by means of attachment points arranged along a straight line and then the printing beam and lower beam are attached to provide a vibration- and deformation-resistant chassis relative to which all the other printer components are referenced. Slider rods are mounted on the printer carriage beam by means of screws which hold the rods against the beam to keep them straight. The screws also pass through apertures in rod supports, the apertures being sized to permit longitudinal thermal movements of the rods relative to the beam.

Abstract: A paper cutter assembly for a printer/plotter is mounted on the printhead carriage for movement therewith to avoid separate mounting and guide structure. A cutter wheel is mounted in a housing for cam induced movement between a raised inactive position and a lower active position by engagement of a cam element carrier mounted for movement in the cutter housing with structure on the printer chassis. The printer platen has a stationary cutter bar which extends in a channel in the platen transversely of the path of paper movement and has a cutter wheel receiving well at one end of the channel into which the cutter wheel drops without contacting the platen or cutter bar at commencement of a cutting operation. Camming surfaces on the platen engage the side of a cutter drive wheel to move the cutter wheel into engagement with the cutter bar and then to raise the cutter wheel to the proper amount of operational overlap of the cutting edges as the cutter assembly moves across the paper path.

Abstract: A paper cutter assembly for a printer/plotter is mounted on the printhead carriage for movement therewith to avoid separate mounting and guide structure. A cutter wheel is mounted in a housing for cam induced movement between a raised inactive position and a lower active position by engagement of a cam element carrier mounted for movement in the cutter housing with structure on the printer chassis. The printer platen has a stationary cutter bar which extends in a channel in the platen transversely of the path of paper movement and has a cutter wheel receiving well at one end of the channel into which the cutter wheel drops without contacting the platen or cutter bar at commencement of a cutting operation. Camming surfaces on the platen engage the side of a cutter drive wheel to move the cutter wheel into engagement with the cutter bar and then to raise the cutter wheel to the proper amount of operational overlap of the cutting edges as the cutter assembly moves across the paper path.

Abstract: An inkjet printing system having a replaceable set of ink-related components which are installed together and replaced together with a single ink delivery system for each different color of ink. The set includes an ink printhead with an inlet port, an ink supply module, and a printhead service module, each of which is manually mountable by a user onto an inkjet printer. The ink supply module contains enough ink to completely replenish an entire printhead reservoir several times before the expected useful life of the printhead has expired, at which time a user can replace the entire set of ink-related components for a particular color. Similarly, the printhead service module is designed for reliable performance for the expected useful life of the printhead. This system enables the entire ink delivery system to be replaced for different printing needs, such as replacing indoor dye-based inks with outdoor pigment based inks.

Abstract: A replaceable ink supply module which provides replenishment of an inkjet printhead includes a collapsible bag, an enclosure box, a connective tube, and an on/off valve. These four components are incorporated into a composite sealed system which remains intact during shipment, storage, installation and operation. The collapsible bag is placed inside of the protective enclosure box and has an end-connect outlet permanently attached to one end of the connective tube. The other end of the connective tube carries a permanently attached on/off valve designed for periodic engagement with an inlet valve of an inkjet printhead.