Patents by Inventor Robert Gleave

Robert Gleave has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Receptor antagonists and their methods of use
    Patent number: 8048907
    Abstract: The present invention relates to novel oxo-prolinamide derivatives of formula (I) which modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of disorders mediated by the P2X7 receptor, for example pain, inflammation and neurodegeneration.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: November 1, 2011
    Assignee: Glaxo Group Limited
    Inventors: Laura J Chambers, Robert Gleave, Stefan Senger, Daryl Simon Walter
  • Novel Receptor Antagonists and Their Methods of Use
    Publication number: 20100144829
    Abstract: The present invention relates to novel oxo-prolinamide derivatives of formula (I) which modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of disorders mediated by the P2X7 receptor, for example pain, inflammation and neurodegeneration.
    Type: Application
    Filed: February 18, 2010
    Publication date: June 10, 2010
    Inventors: Laura J. Chambers, Robert Gleave, Stefan Senger, Daryl Simon Walter
  • Novel Receptor Antagonists and Their Methods of Use
    Publication number: 20080009541
    Abstract: The present invention relates to novel oxo-prolinamide derivatives of formula (I) which modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of disorders mediated by the P2X7 receptor, for example pain, inflammation and neurodegeneration.
    Type: Application
    Filed: July 3, 2007
    Publication date: January 10, 2008
    Applicant: GLAXO GROUP LIMITED
    Inventors: Laura Chambers, Robert Gleave, Stefan Senger, Daryl Walter
  • 7-Azaindole derivatives as cox2 inhibitors
    Publication number: 20060270880
    Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of a variety of conditions and diseases.
    Type: Application
    Filed: August 11, 2004
    Publication date: November 30, 2006
    Inventors: Paul Beswick, Robert Gleave, Martin Swarbrick