Abstract: An anesthetic container includes a bottle having a wall defining a receptacle and a neck with a passage in fluid communication with the receptacle, a valve assembly including a flange, and a ferrule disposed over at least a portion of the flange of the valve assembly and about at least a portion of the neck of the bottle to secure the valve assembly to the bottle. One of the wall of the bottle, the flange of the valve assembly or a wall of the ferrule has at least one vent formed, at least in part, therein that permits air trapped between the ferrule and the valve assembly or the bottle to escape.

Abstract: An anesthetic container includes a bottle having a wall defining a receptacle and a neck with a passage in fluid communication with the receptacle, a valve assembly including a flange, and a ferrule disposed over at least a portion of the flange of the valve assembly and about at least a portion of the neck of the bottle to secure the valve assembly to the bottle. One of the wall of the bottle, the flange of the valve assembly or a wall of the ferrule has at least one vent formed, at least in part, therein that permits air trapped between the ferrule and the valve assembly or the bottle to escape.

Abstract: A system and method to facilitate thickness measurement of bio-material workpiece, preferably a sheet, and to topographically map the sheet into similar thickness zones for later use. In particular, the system may include a three-axis programmable controller for manipulating a bio-material workpiece with respect to a thickness measurement head. The measurement head may include a plurality of sensors for simultaneous measurement of a plurality of points, with the sensors being adapted to contact the sheet or not. A robust human-machine interface is also provided for process control, preferably including a touch-screen monitor. A marking head may be provided for marking the zones or otherwise indicating the thickness in different areas. Two platens are desirably used in parallel for increased thoughput; the workpiece on one platen may be measured while the other is marked. The system and method are especially suited for assessing and marking pericardial tissue for forming heart valve leaflets.

Abstract: The present invention claims a method of producing sterile prefilled syringe bodies. The method comprises the steps of providing a syringe body. The syringe bodies are sterilized and transferred to a sterile environment. While the syringe bodies are maintained in a sterilized condition as they are transferred to the sterile environment. A fluid substance is provided and introduced into the syringe body while the syringe body is within the sterile environment. The fluid substance is also sealed within the syringe body while the syringe body is within the sterile environment.

Abstract: A system and method to facilitate thickness measurement of bio-material workpiece, preferably a sheet, and to topographically map the sheet into similar thickness zones for later use. In particular, the system may include a three-axis programmable controller for manipulating a bio-material workpiece with respect to a thickness measurement head. The measurement head may include a plurality of sensors for simultaneous measurement of a plurality of points, with the sensors being adapted to contact the sheet or not. A robust human-machine interface is also provided for process control, preferably including a touch-screen monitor. A marking head may be provided for marking the zones or otherwise indicating the thickness in different areas. Two platens are desirably used in parallel for increased thoughput; the workpiece on one platen may be measured while the other is marked. The system and method are especially suited for assessing and marking pericardial tissue for forming heart valve leaflets.

Abstract: A syringe having a syringe body of a norbornene and ethylene copolymer, the body defining a chamber for containing water and having an opening, a plunger seal of a halobutyl-based elastomer sealing the opening; and wherein the syringe meets all requirements of the United States Pharmocopoeia for sterile water for injection.

Abstract: A system and method to facilitate thickness measurement of bio-material workpiece, preferably a sheet, and to topographically map the sheet into similar thickness zones for later use. In particular, the system may include a three-axis programmable controller for manipulating a bio-material workpiece with respect to a thickness measurement head. The measurement head may include a plurality of sensors for simultaneous measurement of a plurality of points, with the sensors being adapted to contact the sheet or not. A robust human-machine interface is also provided for process control, preferably including a touch-screen monitor. A marking head may be provided for marking the zones or otherwise indicating the thickness in different areas. Two platens are desirably used in parallel for increased thoughput; the workpiece on one platen may be measured while the other is marked. The system and method are especially suited for assessing and marking pericardial tissue for forming heart valve leaflets.

Abstract: A cell culture media container is provided. The container comprises a body constructed from flexible film and defining a containment area for containing the cell culture media, the body including a front face and a back face, the front and back face being sealed to each other along at least three sides thereof. The container includes a fill port for filling the containment area with cell culture media, the port being sealed to a face of the body and being so constructed and arranged that it extends from the face normal thereto. The container is constructed from a high barrier, optically clear, radiation sterilizable film.