Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.

Abstract: A method for treating a bacterial, viral, fungal, or vector-induced disease state. A therapeutically effective dose of a metal substance is delivered to the body of a potentially infected organism using a delivery methodology selected from the group consisting of syringes, auto-injectors, pricking devices, buccal embedding, transdermal patches, needle transdermal patches, aerosol inhalers, ingestible dissolvable capsules, encapsulated boluses, needle encapsulated boluses, and electrode catheterization methodologies. The metal substance is selected from the group consisting of silver, gold, copper, zinc, selenium, platinum, and their ions, alloys, salts, and combinations thereof. Preferably, an electrical current is introduced substantially in the course of utilizing the delivery methodology. The electrical current is preferably substantially varied over time, and is still more preferably a reversing electrical current.

Abstract: A porous ceramic support for a gas separation membrane formed by sintering a green body containing grains of a refractory ceramic oxide with a high coefficient of thermal expansion and grains of a reactive binder precursor. Upon sintering, the reactive binder precursor reacts with at least one gaseous, liquid or solid reactant to create a reaction bond that binds the refractory ceramic oxide grains. The support configuration can be a tubular, flat plate, hollow fiber, or multiple-passageway monolith structure.

Abstract: A crossflow membrane device that receives a feedstock at a feed end face and separates the feedstock into permeate and retentate. The device has a membrane support containing at least one monolith of porous material defining a plurality of passageways extending longitudinally from the feed end face of the monolith to a retentate end face of the monolith through which the feedstock flows to pass retentate from the device. A permselective membrane coating of finer pore size than that of the porous material is applied to the passageway wall surfaces of the monolith. At least one permeate conduit is formed within the monolith, the conduit containing a plurality of longitudinal permeate chambers communicating with a means of permeate introduction at or near the feed end face and permeate withdrawal at or near the retentate end face.

Abstract: A porous ceramic support for a gas separation membrane formed by sintering a green body containing grains of a refractory ceramic oxide with a high coefficient of thermal expansion and grains of a reactive binder precursor. Upon sintering, the reactive binder precursor reacts with at least one gaseous, liquid or solid reactant to create a reaction bond that binds the refractory ceramic oxide grains. The support configuration can be a tubular, flat plate, hollow fiber, or multiple-passageway monolith structure.

Abstract: A porous reaction-bonded magnesia body with small or negligible shrinkage between the green state and the fired state. The body made by forming a green (i.e., unfired) body of mixed powders containing coarse grains of magnesia in combination with at least one reactive element, and optionally other ceramic oxides and/or compounds, followed by sintering in an oxidizing atmosphere. During sintering, oxidation and/or reaction of the element grain results in an overall volume change that is negligibly small or zero. The resulting body is highly porous, and may be used as a support for a semi-permeable membrane, especially relatively high coefficient of thermal expansion, high-temperature gas separation membranes.

Abstract: A membrane device that receives a feedstock at a feed end face and separates the feedstock into a gas-phase permeate and retentate. The device has a membrane support containing at least one monolith of porous material defining a plurality of passageways extending longitudinally from the feed end face of the monolith to a retentate end face of the monolith through which the feedstock flows to pass retentate from the device. A permselective membrane coating is applied to the passageway wall surfaces of the monolith. At least one permeate conduit is formed within the monolith, the conduit containing a plurality of longitudinal permeate chambers communicating with a means of a sweep fluid introduction into the chambers and sweep fluid and permeate withdrawal from the chambers. The permeate is separated from feed and retentate, and the permeate is removed in a sweep fluid circulated through the permeate conduit.

Abstract: A membrane device comprised of a porous monolith support formed from a reaction-bonded ceramic powder, fired in an oxygen-free atmosphere, the monolith defining a plurality of passageways extending longitudinally from one end face of the monolith to an opposing end face. A semipermeable membrane suitable for separating a feedstock into permeate and retentate is applied to the passageway walls of said monolith. The semipermeable membrane can be selected from the group of membranes suitable for microfiltration, ultrafiltration, nanofiltration, pervaporation, reverse osmosis, and gas separations.

Abstract: A crossflow membrane device that receives a feedstock at a feed end face and separates the feedstock into permeate and retentate. The device has a membrane support containing at least one monolith of porous material defining a plurality of passageways extending longitudinally from the feed end face of the monolith to a retentate end face of the monolith through which the feedstock flows to pass retentate from the device. A permselective membrane coating of finer pore size than that of the porous material is applied to the passageway wall surfaces of the monolith. At least one permeate conduit is formed within the monolith, the conduit containing a plurality of longitudinal permeate chambers communicating with a means of permeate introduction at or near the feed end face and permeate withdrawal at or near the retentate end face.