Abstract: A computer-implemented method for classifying cancer uses image analysis software to analyze a digital histology image of tumour cells of a patient. The image analysis software is trained to segment tissue regions, identify nuclei, and measure nuclear features of a plurality of nuclei. Summary statistics for nuclear feature values are obtained and one or multiple prognostic classifiers are applied to the patient's nuclear feature values to produce a prognostic score for the patient from the prognostic classifiers. The prognostic score may be for recurrence-free survival of the patient or may discriminate between high-grade and low-grade tumours.

Abstract: A multi-gene model is employed in methods for accurately classifying benign and malignant prostate cancer and reliably identifying prostate cancer in samples, with false positive and negative rates below 7%. A single gene model is employed in methods for detecting aggressive prostate cancer, prostate cancer patients at risk of developing biochemical recurrence, and prostate cancer patients suitable for treatment with an additional and/or alternative therapy. The methods may be implemented with next generation sequencing (NGS) or methylation-specific PCR (MSP). The MSP may use a mastermix specifically designed for use with bisulfite converted DNA in singleplex and multiplex assays.

Abstract: The present invention relates to a screen cylinder that is particularly suitable for screening, filtering, fractionating, or sorting cellulose pulp or fiber suspensions of the pulp and paper industry or other similar suspensions. The present invention relates more particularly to screening devices of the type comprising a plurality of screen wires positioned axially and at a small spacing parallel to each other, and a plurality of bar-wires arranged in a reverse orientation to the screen wires.

Abstract: A sclereid concentrator is an apparatus designed to concentrate sclereids found in pulp. The sclereid concentrator is based around a mini-hydrocyclone. When a slush pulp sample is passed through the mini-hydrocyclone, practically all the sclereids are removed by the reject port. The reject sample is then collected, screened and the sclereids are then manually counted or an image analysis system is used to automatically count the sclereids. This count, expressed on the basis of the original sample mass, gives an accurate measurement of the sclereid contamination level in the pulp. There is provided a sclereid concentrator device, a procedure to produce almost pure sclereids and a method to count sclereids manually or by image analysis.