Abstract: Provided herein is a newly developed immunoassay that can detect progerin with high sensitivity, but which does not detect wildtype lamin A. Applications of the newly developed immunoassay in novel methods for diagnosing, prognosing, and treating progeria are also described.

Abstract: Provided is a process of enhancing or suppressing measures of relationships between documents based on the relationships arising from text pertaining to selected topics, the process including: obtaining a corpus of documents; obtaining a set of topics by self-extracting topics according to the tokens present in text of the documents or manual provision; receiving a selected topic among the set of topics, the selection indicating that relationships between the documents are to be enhanced or suppressed in virtue of the relationships arising from text relating to the selected topic; forming a relationship graph of the documents, wherein: the relationships between pairs of the documents are determined based on co-occurrence of n-grams in the pairs of the documents, and wherein the relationships are enhanced or suppressed in response to co-occurring n-grams being in the respective set of n-grams of the selected topic.

Abstract: Provided is a process including obtaining a corpus having a plurality of time-stamped documents; detecting topics in the unstructured natural language text; determining temporal-metrics of the topics based on time-stamps of documents to which the topics pertain; and predicting based on the temporal-metrics, whether a given topic among the plurality of topics will appear in future time-stamped documents.

Abstract: Provided is a process including obtaining a corpus having a plurality of time-stamped documents; detecting topics in the unstructured natural language text; determining temporal-metrics of the topics based on time-stamps of documents to which the topics pertain; and predicting based on the temporal-metrics, whether a given topic among the plurality of topics will appear in future time-stamped documents.

Abstract: Method of treating or diagnosing cancers involving P-cadherin expression are provided using ligands that target P-cadherin, especially human anti-P-cadherin antibodies. Also provided are screens for identifying anti-P-cadherin antibodies having therapeutic activity.

Abstract: Method of treating or diagnosing cancers involving P-cadherin expression are provided using ligands that target P-cadherin, especially human anti-P-cadherin antibodies.