Patents by Inventor Robert Granier
Robert Granier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230251182Abstract: Reusable network of spatially-multiplexed microfluidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid.Type: ApplicationFiled: April 19, 2023Publication date: August 10, 2023Inventors: Ramin Haghgooie, Kenneth T. Kotz, Robert Granier, Anne Celia Petrofsky
-
Patent number: 11644409Abstract: Reusable network of spatially-multiplexed microfliuidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid.Type: GrantFiled: March 8, 2022Date of Patent: May 9, 2023Assignee: The General Hospital CorporationInventors: Ramin Haghgooie, Kenneth T. Kotz, Robert Granier, Anne Celia Petrofsky
-
Publication number: 20220373451Abstract: Reusable network of spatially-multiplexed microfliuidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid.Type: ApplicationFiled: March 8, 2022Publication date: November 24, 2022Inventors: Ramin Haghgooie, Kenneth T. Kotz, Robert Granier, Anne Celia Petrofsky
-
Patent number: 11275018Abstract: Reusable network of spatially-multiplexed microfluidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid.Type: GrantFiled: July 1, 2020Date of Patent: March 15, 2022Assignee: THE GENERAL HOSPITAL CORPORATIONInventors: Ramin Haghgooie, Kenneth T. Kotz, Robert Granier, Anne Celia Petrofsky
-
Publication number: 20210362150Abstract: A modular analytic system includes a base, at least one fluid sample processing module configured to be removably attached to the base, at least one fluid sample analysis module configured to be removably attached to the base, a fluid actuation module positioned on the base, a fluidic network comprising multiple fluidic channels, in which the fluid actuation module is arranged to control transport of a fluid sample between the at least one sample processing module and the at least one sample analysis module through the fluidic network, and an electronic processor, in which the electronic processor is configured to control operation of the fluid actuation module and receive measurement data from the at least one fluid sample analysis module.Type: ApplicationFiled: February 25, 2021Publication date: November 25, 2021Inventors: Robert Granier, Ramin Haghgooie, Ken Kotz, Anne C. Petrofsky, Ronald G. Tompkins
-
Patent number: 10946377Abstract: A modular analytic system includes a base, at least one fluid sample processing module configured to be removably attached to the base, at least one fluid sample analysis module configured to be removably attached to the base, a fluid actuation module positioned on the base, a fluidic network comprising multiple fluidic channels, in which the fluid actuation module is arranged to control transport of a fluid sample between the at least one sample processing module and the at least one sample analysis module through the fluidic network, and an electronic processor, in which the electronic processor is configured to control operation of the fluid actuation module and receive measurement data from the at least one fluid sample analysis module.Type: GrantFiled: February 1, 2019Date of Patent: March 16, 2021Assignee: The General Hospital CorporationInventors: Robert Granier, Ramin Haghgooie, Ken Kotz, Anne C. Petrofsky, Ronald G. Tompkins
-
Publication number: 20200333240Abstract: Reusable network of spatially-multiplexed microfluidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid.Type: ApplicationFiled: July 1, 2020Publication date: October 22, 2020Inventors: Ramin Haghgooie, Kenneth T. Kotz, Robert Granier, Anne Celia Petrofsky
-
Patent number: 10739250Abstract: Reusable network of spatially-multiplexed microfliuidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid.Type: GrantFiled: August 20, 2019Date of Patent: August 11, 2020Assignee: The General Hospital CorporationInventors: Ramin Haghgooie, Kenneth T. Kotz, Robert Granier, Anne Celia Petrofsky
-
Publication number: 20200122141Abstract: An apparatus includes a device for storing a liquid sample, in which the device has a sample acceptance well, one or more storage chambers, and one or more fluidic channels fluidly coupling the sample acceptance well to the one or more storage chambers. The apparatus also includes a well plate having a plate and multiple wells formed in the plate, in which the device and the well plate are configured to be attached to one another.Type: ApplicationFiled: June 6, 2019Publication date: April 23, 2020Inventors: Ramin Haghgooie, Robert Granier, Kenneth T. Kotz, Anne C. Petrofsky
-
Publication number: 20200003676Abstract: Reusable network of spatially-multiplexed microfliuidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid.Type: ApplicationFiled: August 20, 2019Publication date: January 2, 2020Inventors: Ramin Haghgooie, Kenneth T. Kotz, Robert Granier, Anne Celia Petrofsky
-
Patent number: 10436704Abstract: Reusable network of spatially-multiplexed microfluidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid.Type: GrantFiled: December 11, 2018Date of Patent: October 8, 2019Assignee: The General Hospital CorporationInventors: Ramin Haghgooie, Kenneth T. Kotz, Robert Granier, Anne Celia Petrofsky
-
Publication number: 20190262828Abstract: A modular analytic system includes a base, at least one fluid sample processing module configured to be removably attached to the base, at least one fluid sample analysis module configured to be removably attached to the base, a fluid actuation module positioned on the base, a fluidic network comprising multiple fluidic channels, in which the fluid actuation module is arranged to control transport of a fluid sample between the at least one sample processing module and the at least one sample analysis module through the fluidic network, and an electronic processor, in which the electronic processor is configured to control operation of the fluid actuation module and receive measurement data from the at least one fluid sample analysis module.Type: ApplicationFiled: February 1, 2019Publication date: August 29, 2019Inventors: Robert Granier, Ramin Haghgooie, Ken Kotz, Anne C. Petrofsky, Ronald G. Tompkins
-
Patent number: 10335787Abstract: An apparatus includes a device for storing a liquid sample, in which the device has a sample acceptance well, one or more storage chambers, and one or more fluidic channels fluidly coupling the sample acceptance well to the one or more storage chambers. The apparatus also includes a well plate having a plate and multiple wells formed in the plate, in which the device and the well plate are configured to be attached to one another.Type: GrantFiled: October 15, 2015Date of Patent: July 2, 2019Assignee: The General Hospital CorporationInventors: Ramin Haghgooie, Robert Granier, Kenneth T. Kotz, Anne C. Petrofsky
-
Publication number: 20190120748Abstract: Reusable network of spatially-multiplexed microfliuidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid.Type: ApplicationFiled: December 11, 2018Publication date: April 25, 2019Inventors: Ramin Haghgooie, Kenneth T. Kotz, Robert Granier, Anne Celia Petrofsky
-
Patent number: 10220387Abstract: A modular analytic system includes a base, at least one fluid sample processing module configured to be removably attached to the base, at least one fluid sample analysis module configured to be removably attached to the base, a fluid actuation module positioned on the base, a fluidic network comprising multiple fluidic channels, in which the fluid actuation module is arranged to control transport of a fluid sample between the at least one sample processing module and the at least one sample analysis module through the fluidic network, and an electronic processor, in which the electronic processor is configured to control operation of the fluid actuation module and receive measurement data from the at least one fluid sample analysis module.Type: GrantFiled: December 5, 2014Date of Patent: March 5, 2019Assignee: The General Hospital CorporationInventors: Robert Granier, Ramin Haghgooie, Ken Kotz, Anne C. Petrofsky, Ronald G. Tompkins
-
Patent number: 10215687Abstract: Reusable network of spatially-multiplexed microfluidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid.Type: GrantFiled: August 15, 2017Date of Patent: February 26, 2019Assignee: The General Hospital CorporationInventors: Ramin Haghgooie, Kenneth T. Kotz, Robert Granier, Anne Celia Petrofsky
-
Patent number: 10139333Abstract: The present invention provides a microfluidic system, device, and kit for particle analysis. In one example, the device includes a fluid channel for spacing the particles, an excitation waveguide to guide an excitation beam from a source to the fluid channel, and an excitation lens to focus the excitation beam to a width less than the spacing of the particles in the fluid channel. The device also includes a detection lens to guide light transmitted from the channel along a number of paths, axial and scatter light waveguide to receive light guided by the detection lens, a detector to receive transmitted light from the waveguides and generate a detection signal, and a processor configured to receive the detection signal and determine characteristic features of each of the particles based on the detection signal.Type: GrantFiled: October 27, 2014Date of Patent: November 27, 2018Assignee: The General Hospital CorporationInventors: Kenneth T. Kotz, Ramin Haghgooie, Anne C. Petrofsky, Robert Granier, Ronald Tompkins
-
Publication number: 20180088025Abstract: Reusable network of spatially-multiplexed microfluidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid.Type: ApplicationFiled: August 15, 2017Publication date: March 29, 2018Inventors: Ramin Haghgooie, Kenneth T. Kotz, Robert Granier, Anne Celia Petrofsky
-
Patent number: 9759649Abstract: Microfluidic cuvettes and a network of multiplexed channels including such cuvettes. The channels operationally share a main output channel defining an output of the network. A microfluidic channel includes an inlet, a cuvette, and an outlet that is coupled into the main output channel. The network is configured to provide a difference in resistances, to the fluid, by the main output channel and by an individual outlet is sufficient to prevent cross-contamination of different cuvettes, thereby operably isolating individual channels from one another. An individual cuvette is adapted to substantially prevent the formation of air-bubbles as part of the fluid flow through the cuvette and, therefore, to be fully filled and fully emptied. A system and method for photometric measurements of multiple fluid samples employing such network of channels.Type: GrantFiled: November 18, 2013Date of Patent: September 12, 2017Assignee: THE GENERAL HOSPITAL CORPORATIONInventors: Ramin Haghgooie, Kenneth T. Kotz, Robert Granier, Anne Celia Petrofsky
-
Publication number: 20160303563Abstract: A modular analytic system includes a base, at least one fluid sample processing module configured to be removably attached to the base, at least one fluid sample analysis module configured to be removably attached to the base, a fluid actuation module positioned on the base, a fluidic network comprising multiple fluidic channels, in which the fluid actuation module is arranged to control transport of a fluid sample between the at least one sample processing module and the at least one sample analysis module through the fluidic network, and an electronic processor, in which the electronic processor is configured to control operation of the fluid actuation module and receive measurement data from the at least one fluid sample analysis module.Type: ApplicationFiled: December 5, 2014Publication date: October 20, 2016Inventors: Robert Granier, Ramin Haghgooie, Ken Kotz, Anne C. Petrofsky, Ronald G. Tompkins