Abstract: The invention relates to a quick coupling for coupling a tool to the boom of a working machines, comprising a quick coupling part at the boom side and a quick coupling part at the tool side that are latchable to one another via two spaced apart latching axles and an energy circuit coupling for the automatic coupling of an energy connector at the tool side and an energy connector at the boom side that comprises an energy coupling part at the boom side and an energy coupling part at the tool side that move toward one another by pivoting together about a first latching axle on an orbit and thereby automatically couple with one another. At least one of the energy coupling parts is movably supported. The energy circuit coupling comprises a linear guide that compensates the circular relative movement of the energy coupling parts on the pivoting together and guides them linearly toward one another.

Abstract: It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.

Abstract: The invention relates to a quick coupling for coupling a tool to the boom of a working machines, comprising a quick coupling part at the boom side and a quick coupling part at the tool side that are latchable to one another via two spaced apart latching axles and an energy circuit coupling for the automatic coupling of an energy connector at the tool side and an energy connector at the boom side that comprises an energy coupling part at the boom side and an energy coupling part at the tool side that move toward one another by pivoting together about a first latching axle on an orbit and thereby automatically couple with one another. At least one of the energy coupling parts is movably supported. The energy circuit coupling comprises a linear guide that compensates the circular relative movement of the energy coupling parts on the pivoting together and guides them linearly toward one another.