Abstract: Embodiments of topical formulations for administering cerdulatinib or a pharmaceutically acceptable salt, hydrate or solvate thereof are disclosed. Embodiments of methods for preparing the topical formulations are also disclosed. The disclosed formulations are suitable for the treatment of dermatologic conditions such as atopic dermatitis.

Abstract: Compositions for topical administration of a hedgehog inhibitor compound are described. In one embodiment, the hedgehog inhibitor compound is patidegib and the topical composition comprises the compound in a solvent system of a monohydric primary alcohol and a polyol in a w/w ratio of between about 0.9-1.8. In another embodiment, the hedgehog inhibitor is itraconazole and the topical composition comprises the compound in a solvent system comprising a monohydric primary alcohol and an optionally lower alkyl end-capped oligomeric alkylene glycol in a w/w ratio of between about 0.8 and 2.6 and a fused bicyclic ether. Method of using the compositions are also described, where in one embodiment, the compositions are topically applied for treating or preventing basal cell carcinoma.

Abstract: Compositions for topical administration of a hedgehog inhibitor compound are described. In one embodiment, the hedgehog inhibitor compound is patidegib and the topical composition comprises the compound in a solvent system of a monohydric primary alcohol and a polyol in a w/w ratio of between about 0.9-1.8. In another embodiment, the hedgehog inhibitor is itraconazole and the topical composition comprises the compound in a solvent system comprising a monohydric primary alcohol and an optionally lower alkyl end-capped oligomeric alkylene glycol in a w/w ratio of between about 0.8 and 2.6 and a fused bicyclic ether. Method of using the compositions are also described, where in one embodiment, the compositions are topically applied for treating or preventing basal cell carcinoma.

Abstract: The present invention provides topical, e.g., dermal, pharmaceutical compositions comprising an active agent. The present invention further provides methods of preparing such compositions and methods of treating a disease, disorder, or condition, such as a skin disease, using the same.

Abstract: Compositions for topical administration of a hedgehog inhibitor compound are described. In one embodiment, the hedgehog inhibitor compound is patidegib and the topical composition comprises the compound in a solvent system of a monohydric primary alcohol and a polyol in a w/w ratio of between about 0.9-1.8. In another embodiment, the hedgehog inhibitor is itraconazole and the topical composition comprises the compound in a solvent system comprising a monohydric primary alcohol and an optionally lower alkyl end-capped oligomeric alkylene glycol in a w/w ratio of between about 0.8 and 2.6 and a fused bicyclic ether. Method of using the compositions are also described, where in one embodiment, the compositions are topically applied for treating or preventing basal cell carcinoma.

Abstract: Compositions for topical administration of a hedgehog inhibitor compound are described. In one embodiment, the hedgehog inhibitor compound is patidegib and the topical composition comprises the compound in a solvent system of a monohydric primary alcohol and a polyol in a w/w ratio of between about 0.9-1.8. In another embodiment, the hedgehog inhibitor is itraconazole and the topical composition comprises the compound in a solvent system comprising a monohydric primary alcohol and an optionally lower alkyl end-capped oligomeric alkylene glycol in a w/w ratio of between about 0.8 and 2.6 and a fused bicyclic ether. Method of using the compositions are also described, where in one embodiment, the compositions are topically applied for treating or preventing basal cell carcinoma.

Abstract: A downhole tool for use in coiled tubing well operations. The tool includes a gamma ray detector for determining well location information for an associated coiled tubing application. The well location information may relate to well depth and/or the locating and identifying of a particular side branch or lateral leg of the well. Additionally, the gamma ray detector may be utilized to monitor dynamic well conditions in real-time such as the flow of injected fluids or the effectiveness of clean out applications via the coiled tubing.

Abstract: A coiled tubing connection system is used in a well. A connector having an engagement end is used to couple a wellbore device to the end of a coiled tubing. The connector is spoolable, and the engagement end comprises engagement features that facilitate formation of a connection that is dependable and less susceptible to separation.

Abstract: A tilt meter includes a housing structure defining an inner chamber sealed from an environment outside the housing structure. First and second optical fiber sections are provided in the inner chamber. The second optical fiber section is optically coupled to the first optical fiber section, with the second optical fiber section rotated azimuthally with respect to the first optical fiber section. The first and second optical fiber sections are arranged to receive light transmitted from a remote light source, and a tilt of the housing structure induces a differential pressure within the inner chamber to be detected by the first and second optical fiber sections.

Abstract: A distributed fiber optic sensor comprises a conduit having a plurality of sealed compartment extending along its length. A sensing optical fiber is disposed in the conduit and extends through the sealed compartment to form a series of separate sensing elements, each of which separately respond to a parameter of interest that is incident along the length of the conduit. The compartmentalized conduit is surrounding by a protective layer that includes ports therethrough to allow transmission of the parameter through the protective layer to the separate sensing elements.

Abstract: A technique is provided for utilizing optical fiber in a well environment. A well system is combined with a tube-in-tube system designed to protect one or more internal optical fibers. The tube-in-tube system has an entry at one end and a turn around at an opposite end to enable fluid flow between a flow passage within an inner tube and a flow passage within an annulus between the inner tube and a surrounding outer tube. An optical fiber is deployed in and protected by the tube-in-tube system.

Abstract: A system for use in a well includes downhole equipment for positioning in the well, and an optical fiber for deployment in the well, the optical fiber to extend to a location of interest in the well in proximity of the downhole equipment. An analysis unit analyzes detected light signals returned from the optical fiber that has been affected by acoustic events generated by the downhole equipment and to determine a status in the wellbore based on the analyzing.

Abstract: A tilt meter includes a housing structure defining an inner chamber sealed from an environment outside the housing structure. First and second optical fiber sections are provided in the inner chamber. The second optical fiber section is optically coupled to the first optical fiber section, with the second optical fiber section rotated azimuthally with respect to the first optical fiber section. The first and second optical fiber sections are arranged to receive light transmitted from a remote light source, and a tilt of the housing structure induces a differential pressure within the inner chamber to be detected by the first and second optical fiber sections.

Abstract: A technique is provided for utilizing optical fiber in a well environment. A well system is combined with a tube-in-tube system designed to protect one or more internal optical fibers. The tube-in-tube system has an entry at one end and a turn around at an opposite end to enable fluid flow between a flow passage within an inner tube and a flow passage within an annulus between the inner tube and a surrounding outer tube. An optical fiber is deployed in and protected by the tube-in-tube system.

Abstract: A coiled tubing connection system is used in a well. A connector having an engagement end is used to couple a wellbore device to the end of a coiled tubing. The connector is spoolable, and the engagement end comprises engagement features that facilitate formation of a connection that is dependable and less susceptible to separation.

Abstract: Methods, apparatus, and systems for deploying and retrieving sensors downhole are provided. The apparatus can include an outer tubular member disposed about one or more inner tubular members coupled to a fluid directional controller. The fluid directional controller may include a housing separating an interior cavity from an external environment of the wellbore. One end of the outer tubular member and at least one end of an inner tubular member may communicate with the interior cavity. The housing may also include a passageway configured to provide fluid communication between the interior cavity and the external environment. A flow control device may selectively facilitate fluid flow through the passageway. Accordingly, a sensor located in the interior cavity may be selectively exposed to fluid from the external environment. Sensors may be deployed by flowing fluid through a particular tubular member in one direction and retrieved by flowing fluid in another direction.

Abstract: A coiled tubing connection system is used in a well. A connector having an engagement end is used to couple a wellbore device to the end of a coiled tubing. The connector is spoolable, and the engagement end comprises engagement features that facilitate formation of a connection that is dependable and less susceptible to separation.

Abstract: A downhole tool for use in coiled tubing well operations. The tool includes a gamma ray detector for determining well location information for an associated coiled tubing application. The well location information may relate to well depth and/or the locating and identifying of a particular side branch or lateral leg of the well. Additionally, the gamma ray detector may be utilized to monitor dynamic well conditions in real-time such as the flow of injected fluids or the effectiveness of clean out applications via the coiled tubing.

Abstract: A system for use in a well includes downhole equipment for positioning in the well, and an optical fiber for deployment in the well, the optical fiber to extend to a location of interest in the well in proximity of the downhole equipment. An analysis unit analyzes detected light signals returned from the optical fiber that has been affected by acoustic events generated by the downhole equipment and to determine a status in the wellbore based on the analyzing.

Abstract: A technique is provided for utilizing optical fiber in a well environment. A well system is combined with a tube-in-tube system designed to protect one or more internal optical fibers. The tube-in-tube system has an entry at one end and a turn around at an opposite end to enable fluid flow between a flow passage within an inner tube and a flow passage within an annulus between the inner tube and a surrounding outer tube. An optical fiber is deployed in and protected by the tube-in-tube system.