Abstract: The present disclosure generally relates to systems and methods for a stimulation system. Various aspects of the present disclosure relate generally to the treatment of epilepsy, depression and/or other conditions in a subject using a nerve stimulator and, more particularly, to an effective and quicker titration method for selection of stimulation parameters of the nerve stimulator using biological markers that indicate potential therapeutic effects. Some aspects of the present disclosure may utilize a pupillometry sensor synchronized with the VNS stimulation system to compare pupil size of a subject with stimulation on and off and for obtaining filtered pupil response measurements after stimulating each electrode while modulating the stimulation parameters. Thus, aspects of the present disclosure allow for quicker titration of programmable stimulation parameters (e.g.

Abstract: The disclosure provides systems and methods for neuromodulation using a housing that at least partially contains a stimulator assembly, wherein the stimulator assembly is configured to generate vibration by mechanical oscillation and/or using a sound wave; and wherein the vibration generated by the stimulator assembly is configured to therapeutically treat the subject by stimulating one or more nerves when the housing is placed in proximity to or on a skin surface of a subject.

Abstract: The disclosure provides systems and methods for detecting, monitoring, and/or treating obstructive sleep apnea, as well as other conditions, using vital sign and/or biometric data collected and/or imputed from one or more photoplethysmography sensors in conjunction with vital sign and/or biometric data from one or more additional sensors such as activity, body position, ECG, HR, or SpO2 levels, e.g., as feedback to control therapy and/or to titrate therapy on a periodic basis.

Abstract: Electrode arrays for biological implants are disclosed. The present disclosure provides array designs for improving apposition (reducing the space between the array and neural tissue). The present disclosure also provides electrode array designs that can be made approximately spherical to increase the field of view of a visual prosthesis while still maintaining good apposition to neural tissue.

Abstract: A computer-implemented loan origination system has a processor that generates a plurality of first level objects, generates a plurality of second level objects, generates an object linkage between the plurality of first level objects, and automatically propagates an update of one of a second subset of the plurality of second level objects to a first subset of the plurality of second level objects. The plurality of first level objects includes a sales object and an operations object. Furthermore, the first subset of the plurality of second level objects corresponds to, and is accessible by, the sales object; whereas the second subset of the plurality of second level objects corresponds to, and us accessible by, the operations object. The object linkage provides each of the plurality of first level objects shared access to each of the plurality of second level objects.

Abstract: A computer-implemented loan origination system has a memory device that stores an object specific workflow data structure corresponding to each of a plurality of object-specific workflows. The object specific workflow data structure has a plurality of workflow rules corresponding to advancement through each of the plurality of object-specific workflows in a workflow guidance interface that provides a graphical representation of a loan origination workflow. The computer-implemented loan origination system has a processor that generates the workflow guidance interface, which simultaneously operates in conjunction with the computer-implemented loan origination system. The processor also generates a plurality of data objects, which include a lead object, a contact object, an opportunity object, and a loan object. The processor generates the plurality of object-specific workflows corresponding to each of the plurality of data objects.

Abstract: An integrated loan origination system and customer relationship management computer-implement platform has a memory device that stores an integrated loan origination system and customer relationship management data structure. Further, a receiver receives, from a lender computer-implemented platform, a lead for loan origination. Additionally, a processor invokes, without an application programming interface, a customer relationship management engine and a loan origination engine. The customer relationship management engine determines that generating a new lead object for the lead would impose a redundancy, merges the lead data into an existing lead object in the integrated loan origination system and customer relationship management data structure without generating a new lead object, and generates an alert based on the redundancy.

Abstract: Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced.

Abstract: Electrode arrays for biological implants are disclosed. The present disclosure provides array designs for improving apposition (reducing the space between the array and neural tissue). The present disclosure also provides electrode array designs that can be made approximately spherical to increase the field of view of a visual prosthesis while still maintaining good apposition to neural tissue.

Abstract: Electrode arrays for biological implants are disclosed, particularly for stimulating a retina. The present disclosure provides array for improving apposition (reducing the space between the array and the retina. The present disclosure also provides electrode array designs that can be made approximately spherical to increase the field of view of a visual prosthesis while still maintaining good apposition.

Abstract: The present invention is a method of processing a video image in an electronic video processor including the steps of receiving an input image having an input field of view, generating a processed image from the input image, and having an output field of view smaller than the input field of view, searching for a predetermined pattern within the input image, providing an indication when the predetermined pattern is found in the input image, and zooming the processed image to the input field of view and highlighting the predetermined pattern in the processed image in response to the indication.

Abstract: A method for manufacturing a flexible circuit electrode array adapted to electrically communicate with organic tissue including the following steps: a) providing a flexible polymer base layer; b) curing the base layer; c) depositing a metal layer on base layer; d) patterning the metal layer and forming metal traces on the base layer; e) roughening the surface of the base layer; f) chemically reverting the cure of the surface of the base layer; g) depositing a flexible polymer top layer on the surface of the base layer and the metal traces; h) curing the top layer and the surface of the base layer forming one single flexible polymer layer; and i) creating openings through the single layer to the metal trace layer.

Abstract: A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on the polymer base layer and the metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.

Abstract: A visual prosthesis apparatus and a method for limiting power consumption in a visual prosthesis apparatus. The visual prosthesis apparatus comprises a camera for capturing a video image, a video processing unit associated with the camera, the video processing unit configured to convert the video image to stimulation patterns, and a retinal stimulation system configured to stop stimulating neural tissue in a subject's eye based on the stimulation patterns when an error is detected in a forward telemetry received from the video processing unit.

Abstract: The invention provides a token configured to show a time-dependent code produced by an algorithm, e.g. a pseudorandom code produce by a hash-based algorithm. A token of the invention optionally has a large character size of the shown code, a short code, a long code update interval, and/or a wall mount. The invention also provides a system of a token and a server running a validation algorithm that uses the same code-time correlation and can receive an input comprising a historical token-produced code or time and return the corresponding time or code, respectively. Tokens and systems of the invention are optionally useful to provide site visit verification which allow a first user to record a code from a token mounted at a desired site, and a second user to, at a later time, determine when the code was produced, thereby verifying that the first user visited the site at a given time.

Abstract: The invention is a retinal implant device to stimulate a retina of an eye thereby producing a specific effect in the eye, such as a vision or drug treatment of a chronic condition. The retinal device is made of a retinal implant that is positioned subretinally and that contains a multitude of stimulation sites that are in contact with the retina. A connection carries a stimulating electrical signal or a drug. The connection passes transretinally through the retina and into a vitreous cavity of the eye, thereby minimizing damage to a nutrient-rich choroid. A lead is attached to a source of drugs or electrical energy, which is located outside the eye. The lead passes through a sclera at a point near a front of the eye to avoid damage to the retina.

Abstract: The present invention is a method of processing a video image in an electronic video processor including the steps of receiving an input image having an input field of view, generating a processed image from the input image, and having an output field of view smaller than the input field of view, searching for a predetermined pattern within the input image, providing an indication when the predetermined pattern is found in the input image, and zooming the processed image to the input field of view and highlighting the predetermined pattern in the processed image in response to the indication.

Abstract: The present invention relates to a saliency-based apparatus and methods for visual prostheses. A saliency-based component processes video data output by a digital signal processor before the video data are input to the retinal stimulator. In a saliency-based method, an intensity stream is extracted from an input image, feature maps based on the intensity stream are developed, plural most salient regions of the input image are detected and one of the regions is selected as a highest saliency region.

Abstract: The present invention is a method of improving the persistence of electrical neural stimulation, and specifically a method of improving the persistence of an image supplied to a retina, or visual cortex, through a visual prosthesis. A continuously stimulated retina, or other neural tissue, will desensitize after a time period in the range of 20 to 150 seconds. However, an interruption of the stimulation on the order of a few milliseconds will restore the retinal sensitivity without the user perceiving the interruption, or with the user barely perceiving the interruption.

Abstract: A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on the polymer base layer and the metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.